1.14.15.3: alkane 1-monooxygenase

This is an abbreviated version!
For detailed information about alkane 1-monooxygenase, go to the full flat file.

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Synonyms

1-hydroxylase, alkane 1-hydrolase, alkane hydroxylase, alkane mono-oxygenase, alkane monooxygenase, alkane omega-hydroxylase, alkane-1-monooxygenase 1, alkane-1-monooxygenase 2, AlkB, AlkB1, AlkB2, AlkW1, AlkW2, AlmA, AlmA-like alkane hydroxylase, BMO, butane monooxygenase, CYP omega hydroxylase, CYP omega-hydroxylase, Cyp153, CYP153 homologue, CYP153A, CYP153D17, CYP4 P450, CYP450 4A omega-hydroxylase, CYP450 omega-hydroxylase, CYP4A, CYP4A10, CYP4A11, CYP4A14, CYP4AII, CYP4d21, CYP86A1, CYP86B1, CYP94A1, CYPA11 P450, CYPIVA1, CYPIVA11, CYPIVA2, CYPIVA3, CYPIVA5, CYPIVA6, CYPIVA7, cytochrome P-450 omega-hydroxylase, cytochrome P450 alkane hydroxylase, cytochrome P450 omega hydroxylase, cytochrome P450-dependent fatty acid omega-hydroxylase, diiron omega-hydroxylase, FA omega-hydroxylase, fatty acid omega-hydrolase, Fatty acid omega-hydroxylase, Gpo1, hexane hydroxylase, Lauric acid omega-hydroxylase, MAH1-1, MAH1-2, male-specific fatty acid omega-hydroxylase, medium-chain alkane hydroxylase, methane monooxygenase, More, omega hydroxylase, omega-hydrolase, omega-hydroxylase, P-450 HK omega, P450-HL-omega, P452, Prm1ABCD, Prm2ABCD, propane monooxygenase, Rieske-type alkane monooxygenase, sex-specific enzyme 1, SXE1, UAM-Ps1, very long chain fatty acid hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.15.3 alkane 1-monooxygenase

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Results	in table
9	Activating Compound
1263	AA Sequence
14	Application
1	CAS Registry Number
36	Cloned(Commentary)
69	Cofactor
4	Crystallization (Commentary)
611	Disease/ Diagnostics
19	Expression
39	General Information
4	General Stability
57	Inhibitors
2	Ki Value [mM]
16	KM Value [mM]
46	Localization
26	Metals/Ions
19	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
419	Organism
5	Pathway
1	PDB ID
13	pH Optimum
1	pH Range
1	Posttranslational Modification
40	Protein Variants
13	Purification (Commentary)
1	Reaction
4	Reaction Type
164	Reference
3	Renatured (Commentary)
44	Source Tissue
15	Specific Activity [micromol/min/mg]
7	Storage Stability
288	Substrates and Products (Substrate)
17	Subunits
195	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
5	Temperature Stability [°C]
33	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.14.15.3 - alkane 1-monooxygenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

arachidonic acid + NADPH + H+ + O2

20-hydroxyeicosatetraenoic acid + NADP+ + H2O

2 entries

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

29 entries

n-alkane + NADPH + H+ + O2

n-alkanol + NADP+ + H2O

3 entries

octane + reduced rubredoxin + O2

1-octanol + oxidized rubredoxin + H2O

3 entries

additional information

?

-

2 entries

arachidonic acid + NADPH + H+ + O2

20-hydroxyeicosatetraenoic acid + NADP+ + H2O

Homo sapiens

-

-

285372, 285379, 285381, 285382

-

-

?

arachidonic acid + NADPH + H+ + O2

20-hydroxyeicosatetraenoic acid + NADP+ + H2O

Oryctolagus cuniculus

-

-

285384

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Alcanivorax borkumensis

-

-

659069

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Alcanivorax borkumensis AP1

-

-

659069

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Amorphotheca resinae

-

-

285380

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Amorphotheca resinae ATCC 22711

-

-

285380

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Candida maltosa

-

-

285374, 285378

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Candida maltosa EH15

-

-

285374

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Corynebacterium sp.

-

-

285362

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Corynebacterium sp. 7E1C

-

-

285362

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Fusarium oxysporum

-

-

285373, 285375

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Fusarium oxysporum MT-811

-

-

285375

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Gordonia sp.

-

-

658306

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Gordonia sp. TF6

-

-

658306

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Homo sapiens

-

-

285372, 285379, 285381, 285382

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Lodderomyces elongisporus

-

-

285368, 285369

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Lodderomyces elongisporus EH15D

-

-

285368, 285369

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Mycobacterium tuberculosis

-

-

659069

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Mycobacterium tuberculosis H37Rv

-

-

659069

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Oryctolagus cuniculus

-

-

285371, 285376, 285377

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Pseudomonas aeruginosa

-

-

285367, 659024

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Pseudomonas aeruginosa S7B1

-

-

285367

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Pseudomonas oleovorans

-

-

285361, 285363, 285364, 285365, 285366, 285370

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Pseudomonas putida

-

-

657600, 659069

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Pseudomonas putida

-

possible role in compensating low hydrocarbon concentrations

659063

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Pseudomonas putida GPo1 / ATCC29347

-

-

657600

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Pseudomonas putida GPo1 / ATCC29347

-

possible role in compensating low hydrocarbon concentrations

659063

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Pseudomonas putida GPo1 / ATCC29347

-

-

659069

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Rattus norvegicus

-

-

285382

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Rhodococcus sp.

Q93DM7, Q93DN3, Q93DN4, Q93DN5

-

657581

-

-

?

n-alkane + NAD(P)H + H+ + O2

n-alkanol + NAD(P)+ + H2O

Vicia sativa

-

-

285376

-

-

?

n-alkane + NADPH + H+ + O2

n-alkanol + NADP+ + H2O

Pseudomonas oleovorans

-

initial activation of alkanes

658713

-

-

?

n-alkane + NADPH + H+ + O2

n-alkanol + NADP+ + H2O

Pseudomonas putida

-

-

671481

-

-

?

n-alkane + NADPH + H+ + O2

n-alkanol + NADP+ + H2O

Pseudomonas putida GPo1 / ATCC29347

-

-

671481

-

-

?

octane + reduced rubredoxin + O2

1-octanol + oxidized rubredoxin + H2O

Alcanivorax borkumensis

-

-

725650

-

-

?

octane + reduced rubredoxin + O2

1-octanol + oxidized rubredoxin + H2O

Pseudomonas putida

-

-

724025

-

-

?

octane + reduced rubredoxin + O2

1-octanol + oxidized rubredoxin + H2O

Pseudomonas putida GPo1 / ATCC29347

-

-

724025

-

-

?

additional information

?

-

Homo sapiens

-

20-hydroxyeicosatetraenoic acid modulates renal transport activities

285382

-

-

?

additional information

?

-

Pseudomonas putida

-

physiological role of enzyme complex is to initiate the monoterminal oxidation of alkane chains

661967

-

-

?