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1.14.14.9: 4-hydroxyphenylacetate 3-monooxygenase

This is an abbreviated version!
For detailed information about 4-hydroxyphenylacetate 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.9

Reaction

4-hydroxyphenylacetate
+
FADH2
+
O2
=
3,4-Dihydroxyphenylacetate
+
FAD
+
H2O

Synonyms

4 HPA 3-hydroxyylase, 4-HPA hydroxylase, 4-hydroxyphenylacetate 3-hydroxylase, 4-hydroxyphenylacetic acid 3-hydroxylase, 4HPA 3-monooxygenase, 4HPA3H, C2-hpah, EC 1.14.13.3, HPA 3-hydroxylase, HpaB, hpaBC, HpaC, HPAH, More, p-hydroxyphenylacetate 3-hydroxylase, p-hydroxyphenylacetate hydroxylase, p-hydroxyphenylacetic 3-hydroxylase, TPY_2462, two-component p-hydroxyphenylacetate hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.9 4-hydroxyphenylacetate 3-monooxygenase

Substrates Products

Substrates Products on EC 1.14.14.9 - 4-hydroxyphenylacetate 3-monooxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(3,4-dihydroxyphenyl)acetate + NADH + H+ + O2
? + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
2,4-dihydroxybenzoate
?
show the reaction diagram
-
-
-
-
?
2,5-dihydroxyphenylacetate + ?
?
show the reaction diagram
-
155% of 4-hydroxyphenylacetate activity
-
-
?
2-(4-hydroxyphenyl)ethanol + NADH + H+ + O2
? + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
2-phenylbutyric acid + H2
?
show the reaction diagram
-
86% of 4-hydroxyphenylacetate activity
-
-
?
2-phenylpropionic acid + ?
?
show the reaction diagram
-
77% of 4-hydroxyphenylacetate activity
-
-
?
3,4-dihydroxybenzoate + ?
?
show the reaction diagram
-
30% of 4-hydroxyphenylacetate activity
-
-
?
3,4-dihydroxyphenylacetate + ?
?
show the reaction diagram
3,4-dihydroxyphenylacetate + FAD + H2O
4-hydroxyphenylacetate + FADH2 + O2
show the reaction diagram
-
-
-
-
r
3-(3,4-dihydroxyphenyl)-propanoic acid + FADH2 + O2
3-(3,4,5-trihydroxyphenyl)-propanoic acid + FAD + H2O
show the reaction diagram
low activity
-
-
?
3-(4-hydroxyphenyl)-propanoic acid + FADH2 + O2
3-(3,4-dihydroxyphenyl)-propanoic acid + FAD + H2O
show the reaction diagram
-
-
-
?
3-(4-hydroxyphenyl)propionate + ?
3-(3,4-dihydroxy)phenylpropionate + ?
show the reaction diagram
3-hydroxyphenylacetate + FMNH2 + O2
3,4-hydroxyphenylacetate + FMN + H2O
show the reaction diagram
3-hydroxyphenylacetate + NAD(P)H + O2
3,4-hydroxyphenylacetate + NAD(P)+ + H2O
show the reaction diagram
3-hydroxyphenylacetate + NADH + H+ + O2
3,4-hydroxyphenylacetate + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
3-hydroxyphenylacetate + NADH + O2
3,4-hydroxyphenylacetate + NAD+ + H2O
show the reaction diagram
4-aminobenzoate + ?
4-amino-3-hydroxybenzoate + ?
show the reaction diagram
-
-
-
?
4-aminophenylacetate + ?
4-amino-3-hydroxyphenylacetate + ?
show the reaction diagram
4-aminophenylacetate + FMNH2 + O2
4-amino-3,5-dihydroxyphenylacetate + FMN + H2O
show the reaction diagram
-
-
-
?
4-bromophenol + NADH + H+ + O2
4-bromocatechol + NAD+ + H2O
show the reaction diagram
rate of halophenol consumption 2.9 microM/min/g cell dry weight
-
-
?
4-chlorophenol + NADH + H+ + O2
4-chlorocatechol + NAD+ + H2O
show the reaction diagram
rate of halophenol consumption 3.3 microM/min/g cell dry weight
-
-
?
4-coumarate + NADH + H+ + O2
? + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
4-coumaric acid + FADH2 + O2
caffeic acid + FAD + H2O
show the reaction diagram
4-fluorophenol + NADH + H+ + O2
4-fluorocatechol + NAD+ + H2O
show the reaction diagram
rate of halophenol consumption 5.3 microM/min/g cell dry weight
-
-
?
4-fluorophenylacetate + NADH + O2
4-fluoro-3-hydroxyphenylacetate + NAD+ + H2O
show the reaction diagram
-
-
-
?
4-hydroxybenzoate + ?
3,4-dihydroxybenzoate + ?
show the reaction diagram
-
15% of 4-hydroxyphenylacetate activity
-
?
4-hydroxyphenylacetate + FADH2 + O2
3,4-dihydroxyphenylacetate + FAD + H2O
show the reaction diagram
4-hydroxyphenylacetate + FMNH + O2
3,4-dihydroxyphenylacetate + FMN + H2O
show the reaction diagram
4-hydroxyphenylacetate + FMNH2 + O2
3,4-dihydroxyphenylacetate + FMN + H2O
show the reaction diagram
-
-
-
-
?
4-hydroxyphenylacetate + NAD(P)H + H+ + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
show the reaction diagram
4-hydroxyphenylacetate + NAD(P)H + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
show the reaction diagram
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
show the reaction diagram
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
show the reaction diagram
4-hydroxyphenylacetate + NADPH + H+ + O2
3,4-dihydroxyphenylacetate + NADP+ + H2O
show the reaction diagram
4-hydroxyphenylacetic acid + O2 + NADH + H+
3,4-dihydroxyphenylacetic acid + H2O + NAD+
show the reaction diagram
4-hydroxyphenylethanol + O2 + NADH + H+
3,4-dihydroxyphenylethanol + H2O + NAD+
show the reaction diagram
4-iodophenol + NADH + H+ + O2
4-iodocatechol + NAD+ + H2O
show the reaction diagram
rate of halophenol consumption 1.7 microM/min/g cell dry weight
-
-
?
caffeic acid + FADH2 + O2
3,4,5-trihydroxycinnamic acid + FAD + H2O
show the reaction diagram
-
-
-
?
catechol + ?
?
show the reaction diagram
-
30% of 4-hydroxyphenylacetate activity
-
-
?
coniferaldehyde + FADH2 + O2
5-hydroxyconiferaldehyde + FAD + H2O
show the reaction diagram
-
-
-
?
DL-4-hydroxymandelic acid + NADH + H+ + O2
? + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
ferulic acid + FADH2 + O2
5-hydroxyferulic acid + FAD + H2O
show the reaction diagram
-
-
-
?
L-(3,4-dihydroxy)phenylalanine + ?
?
show the reaction diagram
-
10% of 4-hydroxyphenylacetate
-
?
L-tyrosine + ?
L-(3,4-dihydroxy)phenylalanine + ?
show the reaction diagram
-
8% of 4-hydroxyphenylacetate activity
-
?
L-tyrosine + FADH2 + O2
L-(3,4-dihydroxy)phenylalanine + FAD + H2O
show the reaction diagram
methyl 4-hydroxybenzoate + NADH + H+ + O2
? + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
naringenin + FADH2 + O2
? + FAD + H2O
show the reaction diagram
naringin + NADH + H+ + O2
eryodictyol + NADP+ + H2O
show the reaction diagram
octopamine + FMNH + O2
norepinephrine + FMN + H2O
show the reaction diagram
no substrate of wild-type or mutant R263E, R263D, R263A, but substrate of mutant R263D/Y398D
-
-
?
p-coumaric acid + FADH2 + O2
caffeic acid + FAD + H2O
show the reaction diagram
-
-
-
?
p-cresol + ?
?
show the reaction diagram
-
51% of 4-hydroxyphenylacetate activity
-
-
?
phenol + ?
catechol + ?
show the reaction diagram
phenol + NADH + H+ + O2
? + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
phenylacetic acid + ?
?
show the reaction diagram
resveratrol + FADH2 + O2
? + FAD + H2O
show the reaction diagram
riboflavin + NADH + H+
reduced riboflavin + NAD+
show the reaction diagram
-
-
-
-
r
tyramine + FMNH + O2
dopamine + FMN + H2O
show the reaction diagram
no substrate of wild-type or mutant R263E, but substrate of mutants R263D and R263A
-
-
?
umbelliferone + FADH2 + O2
? + FAD + H2O
show the reaction diagram
additional information
?
-