1.14.14.33: ethylenediaminetetraacetate monooxygenase
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Reaction
+ 2 FMNH2 + 2 O2 = + 2 glyoxylate + 2 FMN + 2 H2O
Synonyms
EmoA
ECTree
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Crystallization
Crystallization on EC 1.14.14.33 - ethylenediaminetetraacetate monooxygenase
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to 2.15 A resolution. The structure shows a domain-like insertion into a TIM-barrel, which might serve as a flexible lid for the active site. Docking of MgEDTA2- into EmoA identifies an intricate hydrogen bond network connected to Tyr71, which should lower its pKa. Tyr71, along with nearby Glu70 and a peroxy flavin, facilitates a keto-enol transition of the leaving acetyl group of EDTA. The interaction between EmoA and oxidoreductase EmoB enhances both EmoA and EmoB activities probably through coupled channelling of FMNH2