1.14.14.25: cholesterol 24-hydroxylase

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For detailed information about cholesterol 24-hydroxylase, go to the full flat file.

Reaction

Synonyms

24S-hydroxylase, CH24H, cholesterol 24-hydroxylase, cholesterol 24-monooxygenase, cholesterol 24S hydroxylase, cholesterol 24S-hydroxylase, cholesterol hydroxylase, cholesterol-24S-hydroxylase, CYP46, CYP46A, CYP46A1, cytochrome P-450 46A1, cytochrome P450 46A1, cytochrome P450 cholesterol 24-hydroxylase, EC 1.14.13.98

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.25 cholesterol 24-hydroxylase

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Results	in table
5	Activating Compound
14	AA Sequence
6	Application
2	CAS Registry Number
25	Cloned(Commentary)
49	Cofactor
2	Crystallization (Commentary)
350	Disease/ Diagnostics
11	Expression
32	General Information
19	Inhibitors
1	Ki Value [mM]
10	KM Value [mM]
20	Localization
2	Metals/Ions
5	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
235	Organism
1	Pathway
6	PDB ID
2	pH Optimum
16	Protein Variants
5	Purification (Commentary)
2	Reaction
3	Reaction Type
68	Reference
132	Source Tissue
77	Substrates and Products (Substrate)
5	Subunits
88	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
9	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.14.25 - cholesterol 24-hydroxylase

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SYSTEMATIC NAME

IUBMB Comments

cholesterol,NADPH-hemoprotein reductase:oxygen oxidoreductase (24-hydroxylating)

A P-450 heme-thiolate protein. The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol [2]. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood---brain barrier whereas cholesterol cannot [3]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase [3].