1.14.14.23: cholesterol 7alpha-monooxygenase
This is an abbreviated version!
For detailed information about cholesterol 7alpha-monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.23
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1.14.14.23
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lipoprotein
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hepatocytes
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triglyceride
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biliary
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hmg-coa
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farnesoid
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fecal
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low-density
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hypercholesterolemia
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cholic
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high-fat
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chenodeoxycholic
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3-hydroxy-3-methylglutaryl
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ba
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cyp8b1
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cholestyramine
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enterohepatic
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cholestasis
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hdl
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gallstone
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hypocholesterolemic
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27-hydroxylase
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oxysterols
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cholesteryl
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hmgcr
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cyp27a1
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taurocholate
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cholesterol-lowering
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hypolipidemic
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ldl-cholesterol
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acyl-coa:cholesterol
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27-hydroxycholesterol
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alpha-hydroxylation
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lithogenic
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ursodeoxycholic
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lxralpha
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hnf4alpha
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cyp3a11
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sult2a1
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4alpha
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cholesterogenesis
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gut-liver
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npc1l1
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cholesterol-free
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srebp2
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ldl-receptor
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c1-like
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medicine
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analysis
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obeticholic
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cholestanol
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guggulsterone
- 1.14.14.23
- lipoprotein
- hepatocytes
- triglyceride
- biliary
- hmg-coa
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farnesoid
-
fecal
-
low-density
- hypercholesterolemia
-
cholic
-
high-fat
-
chenodeoxycholic
-
3-hydroxy-3-methylglutaryl
- ba
- cyp8b1
- cholestyramine
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enterohepatic
- cholestasis
- hdl
- gallstone
-
hypocholesterolemic
-
27-hydroxylase
- oxysterols
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cholesteryl
- hmgcr
- cyp27a1
- taurocholate
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cholesterol-lowering
-
hypolipidemic
-
ldl-cholesterol
-
acyl-coa:cholesterol
- 27-hydroxycholesterol
-
alpha-hydroxylation
-
lithogenic
-
ursodeoxycholic
-
lxralpha
-
hnf4alpha
- cyp3a11
- sult2a1
- 4alpha
-
cholesterogenesis
-
gut-liver
-
npc1l1
-
cholesterol-free
-
srebp2
-
ldl-receptor
-
c1-like
- medicine
- analysis
-
obeticholic
- cholestanol
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guggulsterone
Reaction
Synonyms
7alpha-hydroxylase, bile acid-synthetic enzyme, C7alphaOH, cholesterol 7 alpha-hydroxylase, cholesterol 7-alpha hydroxylase, Cholesterol 7-alpha-hydroxylase, Cholesterol 7-alpha-monooxygenase, cholesterol 7a-hydroxylase, cholesterol 7alpha hydroxylase, cholesterol 7alpha-hydroxylase, cholesterol-NADPH oxidoreductase, 7alpha-hydroxylating, CYP125A4, CYP7A, CYP7A1, Cyp7alpha1, CYPVII, cytochrome P450 125A4, EC 1.14.13.17, hepatic cholesterol 7alpha-hydroxylase, More, oxygenase, cholesterol 7alpha-mono-
ECTree
Advanced search results
Engineering
Engineering on EC 1.14.14.23 - cholesterol 7alpha-monooxygenase
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A204C
nucleotide exchange, a naturally occuring promoter polymorphism in the CYP7A1 gene, the genetic variant shows less total cholesterol level decrease in response to dietary changes in different types of dietary intervention studies compared to C204 homozygotes, overview
A278C
nucleotide exchange, a naturally occuring promoter polymorphism in the CYP7A1 gene
C554T
nucleotide exchange, a naturally occuring promoter polymorphism in the CYP7A1 gene
T104L
the mutant is similar to the wild-type in ligand binding and catalytic properties and readily crystallizes with substrates. The structure of the T104L mutant in complex with cholest-4-en-3-one explicitly identifies key residues involved in 7alpha-hydroxylation
additional information
genotyping and frequency of polymorphisms in human populations, overview
additional information
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naturally occuring polymorphisms of gene CYP7AI are C203A and T469C in the promoter region, and IVS6 + G363A in the 3'-end of the gene, the genetic variants are of no physiologic importance
additional information
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naturally occuring promoter variant -204A > C (rs3808607) of the CYP7A1 gene, genotyping, functionality of the -204A > C variant, electrophoretic mobility gel shift assays, overview. The C-construct causes a 78% promoter activity increase and gel-shift assays howed lower affinity for nuclear transcription factors, while in silico experiments predict a binding site for inhibitory nuclear factors RXR-CAR
additional information
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construction of Cyp7a1-tg mice overexpressing rat Cyp7a1, phenotype, overview
additional information
generation of a mutant CYP7A1 promoter luciferase construct with deletion of putative HSE binding site for HSF-1, in the CYP7A1 promoter region (-922 to -901) and determination of luciferase activity in the hepatocytes
additional information
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construction of Cyp7a1-tg mice overexpressing rat Cyp7a1, phenotype, overview
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