1.14.14.22: dibenzothiophene sulfone monooxygenase
This is an abbreviated version!
For detailed information about dibenzothiophene sulfone monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.22
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1.14.14.22
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desulfurization
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erythropolis
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rhodococcus
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2-hydroxybiphenyl
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sulfur
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carbon-sulfur
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flavin
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mesophilic
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paenibacillus
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biodesulfurization
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desulfinase
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petroleum
- 1.14.14.22
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desulfurization
- erythropolis
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rhodococcus
- 2-hydroxybiphenyl
- sulfur
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carbon-sulfur
- flavin
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mesophilic
- paenibacillus
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biodesulfurization
- desulfinase
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petroleum
Reaction
Synonyms
BdsA, DBT sulfone monooxygenase, DBTO2-MO, DBTO2-monooxygenase, dibenzothiophene sulfone monooxygenase, dszA, TdsA
ECTree
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Substrates Products
Substrates Products on EC 1.14.14.22 - dibenzothiophene sulfone monooxygenase
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REACTION DIAGRAM
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3,4,6-trimethyldibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
?
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?
3,6-dimethyldibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
?
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?
? + 2 FMN + H2O
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activity of mutant Q345A
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?
3-methyldibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
? + 2 FMN + H2O
Rhodococcus erythropolis IGTS8 / ATCC 53968
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activity of mutant Q345A
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?
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
Gordonia sp. F.5.25.8
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
Mycolicibacterium phlei GTIS10
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
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-
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
best substrate
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
best substrate
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
Rhodococcus erythropolis IGTS8 / ATCC 53968
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
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-
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
-
-
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
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?
dibenzothiophene-5,5-dioxide + 2 FMNH2 + O2
2'-hydroxybiphenyl-2-sulfinate + 2 FMN + H2O
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?
2,2'-dihydroxybiphenyl + 2 FMN + H2O
i.e. sultine, sultine is nonenzymatically hydrolyzed to form 2'-hydroxybiphenyl 2-sulfinic acid, it is also oxidized to sultone. Once sultone is nonenzymatically formed from sultine, it is immediately converted to 2,2'-dihydroxybiphenyl by DszA
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?
dibenz[c,e][1,2] oxathiin 6-oxide + 2 FMNH2 + O2
2,2'-dihydroxybiphenyl + 2 FMN + H2O
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i.e. sultine, sultine is nonenzymatically hydrolyzed to form 2'-hydroxybiphenyl 2-sulfinic acid, it is also oxidized to sultone. Once sultone is nonenzymatically formed from sultine, it is immediately converted to 2,2'-dihydroxybiphenyl by DszA
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?
dibenz[c,e][1,2] oxathiin 6-oxide + 2 FMNH2 + O2
2,2'-dihydroxybiphenyl + 2 FMN + H2O
i.e. sultine, sultine is nonenzymatically hydrolyzed to form 2'-hydroxybiphenyl 2-sulfinic acid, it is also oxidized to sultone. Once sultone is nonenzymatically formed from sultine, it is immediately converted to 2,2'-dihydroxybiphenyl by DszA
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?
2,2'-dihydroxybiphenyl + 2 FMN + H2O
i.e. sultone
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?
dibenz[c,e][1,2]oxathiin 6,6-dioxide + 2 FMNH2 + O2
2,2'-dihydroxybiphenyl + 2 FMN + H2O
i.e. sultone, sultine is nonenzymatically hydrolyzed to form 2'-hydroxybiphenyl 2-sulfinic acid, it is also oxidized to sultone. Once sultone is nonenzymatically formed from sultine, it is immediately converted to 2,2'-dihydroxybiphenyl by DszA
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?
dibenz[c,e][1,2]oxathiin 6,6-dioxide + 2 FMNH2 + O2
2,2'-dihydroxybiphenyl + 2 FMN + H2O
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i.e. sultone, sultine is nonenzymatically hydrolyzed to form 2'-hydroxybiphenyl 2-sulfinic acid, it is also oxidized to sultone. Once sultone is nonenzymatically formed from sultine, it is immediately converted to 2,2'-dihydroxybiphenyl by DszA
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?
dibenz[c,e][1,2]oxathiin 6,6-dioxide + 2 FMNH2 + O2
2,2'-dihydroxybiphenyl + 2 FMN + H2O
i.e. sultone, sultine is nonenzymatically hydrolyzed to form 2'-hydroxybiphenyl 2-sulfinic acid, it is also oxidized to sultone. Once sultone is nonenzymatically formed from sultine, it is immediately converted to 2,2'-dihydroxybiphenyl by DszA
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?
dibenz[c,e][1,2]oxathiin 6,6-dioxide + 2 FMNH2 + O2
2,2'-dihydroxybiphenyl + 2 FMN + H2O
i.e. sultone
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?
?
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coupled reaction with flavin reductase (TdsD) from thermophilic Paenibacillus sp. strain A11-2
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additional information
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The dszA gene encodes DBT-5,5-dioxide monooxygenase, which catalyzes the conversion of dibenzothiophene sulfone to 2'-hydroxybiphenyl-2-sulfinate
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?
additional information
?
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Mycolicibacterium phlei GTIS10
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The dszA gene encodes DBT-5,5-dioxide monooxygenase, which catalyzes the conversion of dibenzothiophene sulfone to 2'-hydroxybiphenyl-2-sulfinate
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?
additional information
?
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FMN:NADPH oxidoreductase from Vibrio harveyi complements activities of purified DszA and DszC proteins. DszA and DszC are oxygenase units that do not use NAD(P)H directly, but instead use FMNH2 from a FMN:NADPH oxidoreductase for oxygenation. The oxygenase and oxidoreductase units do not interact but exchange electrons, overview. Purified DszC or DszA proteins exhibit no activity in presence of 10 mM FMN, 5 mM NADPH, oxygen, and organosulfur substrates
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additional information
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analysis of the coupled reaction of DszA with the purified NADPH-preferring flavin reductase from Paenibacillus polymyxa A-1, overview
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additional information
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no activity with 4,6-dibutyldibenzothiophene sulfone by wild-type and mutant enzymes
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?
additional information
?
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no activity with dibenzothiophene and 2'-hydroxybiphenyl 2-sulfinic acid, substrate specificity, overview. DszA may recognize the sulfone moiety within the structure of DBT sulfone and sultone
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?
additional information
?
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no activity with dibenzothiophene and 2'-hydroxybiphenyl 2-sulfinic acid, substrate specificity, overview. DszA may recognize the sulfone moiety within the structure of DBT sulfone and sultone
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?
additional information
?
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no activity with dibenzothiophene and 2'-hydroxybiphenyl 2-sulfinic acid, substrate specificity, overview. DszA may recognize the sulfone moiety within the structure of DBT sulfone and sultone. Interaction with purified flavin reductase from the non-DBT-desulfurizing bacterium, Paenibacillus polymyxa A-1, with DszA
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?
additional information
?
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no activity with dibenzothiophene and 2'-hydroxybiphenyl 2-sulfinic acid. DszA may recognize the sulfone moiety within the structure of DBT sulfone and sultone
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?
additional information
?
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analysis of the coupled reaction of DszA with the purified NADPH-preferring flavin reductase from Paenibacillus polymyxa A-1, overview
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?
additional information
?
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no activity with dibenzothiophene and 2'-hydroxybiphenyl 2-sulfinic acid, substrate specificity, overview. DszA may recognize the sulfone moiety within the structure of DBT sulfone and sultone. Interaction with purified flavin reductase from the non-DBT-desulfurizing bacterium, Paenibacillus polymyxa A-1, with DszA
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?
additional information
?
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no activity with dibenzothiophene and 2'-hydroxybiphenyl 2-sulfinic acid, substrate specificity, overview. DszA may recognize the sulfone moiety within the structure of DBT sulfone and sultone
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?
additional information
?
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no activity with dibenzothiophene and 2'-hydroxybiphenyl 2-sulfinic acid. DszA may recognize the sulfone moiety within the structure of DBT sulfone and sultone
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-
?
additional information
?
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Rhodococcus erythropolis IGTS8 / ATCC 53968
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FMN:NADPH oxidoreductase from Vibrio harveyi complements activities of purified DszA and DszC proteins. DszA and DszC are oxygenase units that do not use NAD(P)H directly, but instead use FMNH2 from a FMN:NADPH oxidoreductase for oxygenation. The oxygenase and oxidoreductase units do not interact but exchange electrons, overview. Purified DszC or DszA proteins exhibit no activity in presence of 10 mM FMN, 5 mM NADPH, oxygen, and organosulfur substrates
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?
additional information
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Rhodococcus erythropolis IGTS8 / ATCC 53968
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no activity with 4,6-dibutyldibenzothiophene sulfone by wild-type and mutant enzymes
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?