1.14.13.50: pentachlorophenol monooxygenase
This is an abbreviated version!
For detailed information about pentachlorophenol monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.50
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1.14.13.50
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pcp-degrading
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flavobacterium
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sphingobium
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chlorophenolicum
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tetrachlorohydroquinone
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bioremediation
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tetrachlorobenzoquinone
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dehalogenation
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environmental protection
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arthrobacter
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degradation
- 1.14.13.50
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pcp-degrading
- flavobacterium
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sphingobium
- chlorophenolicum
- tetrachlorohydroquinone
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bioremediation
- tetrachlorobenzoquinone
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dehalogenation
- environmental protection
- arthrobacter
- degradation
Reaction
Synonyms
CpsB, dechlorinase, pentachlorophenol, GM610_18120, oxygenase, pentachlorophenol 4-mono-, PCB hydroxylase, PCP 4-monooxygenase, PCP hydroxylase, PCP-4-monooxygenase, PCP-monooxygenase, PCP4MO, PcpB, PcpD, pentachlorophenol 4-mono-oxygenase, pentachlorophenol 4-monooxygenase, pentachlorophenol dechlorinase, pentachlorophenol dehalogenase, pentachlorophenol hydroxylase, pentachlorophenol monooxygenase, pentachlorophenol-4-monooxygenase, Phe4MO, tetrachlorobenzoquinone reductase
ECTree
1.14.13.50 pentachlorophenol monooxygenaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.14.13.50 - pentachlorophenol monooxygenase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
pentachlorophenol + 2 NADPH + H+ + O2
tetrachlorohydroquinone + 2 NADP+ + chloride + H2O
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product is not tetrachlorobenzoquinone as previously thought, ethyl acetate and glutathione can shift the redox-equilibrium in favor of tetrachlorobenzoquinone, room temperature (23-25°C), 50 mM phosphate buffer, pH 7.0, while with NADPH tetrachlorobenzoquinone is reduced to tetrachlorohydroquinone (with 0.5-1 mol NADPH/mol tetrachlorobenzoquinone 50-65% are reduced, with 2.5 mol or more almost complete reduction occurs), deionized distilled water, pH 6.8 (due to interference of phosphate or Tris-HCl buffer with the detection of tetrachlorohydroquinone)
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?
pentachlorophenol + NADH + H+ + O2
2,3,5,6-tetrachloro-1,4-benzoquinone + NADP+ + chloride + H2O
pentachlorophenol + NADPH + H+ + O2
2,3,5,6-tetrachloro-1,4-benzoquinone + NADP+ + chloride + H2O
degradation of pentachlorophenol
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?
pentachlorophenol + NADPH + H+ + O2
2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
tetrachlorobenzoquinone + NADPH
tetrachlorohydroquinone + NADP+
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second step in pentachlorophenol degradation, physiological role in association with pentachloro monooxygenase, overview
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?
pentachlorophenol + 2 NADPH + H+ + O2
tetrachlorohydroquinone + 2 NADP+ + Cl- + H2O
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?
pentachlorophenol + 2 NADPH + H+ + O2
tetrachlorohydroquinone + 2 NADP+ + Cl- + H2O
wild-type and transformed E. coli cells
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?
pentachlorophenol + 2 NADPH + H+ + O2
tetrachlorohydroquinone + 2 NADP+ + Cl- + H2O
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solitary oxygenolytic pathway for removal of the primary chlorine during PCP degradation, not a hydrolytic one
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?
pentachlorophenol + 2 NADPH + H+ + O2
tetrachlorohydroquinone + 2 NADP+ + Cl- + H2O
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wild-type and mutant strains
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?
pentachlorophenol + NADH + H+ + O2
2,3,5,6-tetrachloro-1,4-benzoquinone + NADP+ + chloride + H2O
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-
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?
pentachlorophenol + NADH + H+ + O2
2,3,5,6-tetrachloro-1,4-benzoquinone + NADP+ + chloride + H2O
Bacillus tropicus AOA-CPS1
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-
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?
pentachlorophenol + NADPH + H+ + O2
2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
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initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview
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-
?
pentachlorophenol + NADPH + H+ + O2
2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
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initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview
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-
?
pentachlorophenol + NADPH + H+ + O2
2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
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initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview
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?
pentachlorophenol + NADPH + H+ + O2
tetrachlorobenzoquinone + NADP+ + chloride + H2O
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ir
pentachlorophenol + NADPH + H+ + O2
tetrachlorobenzoquinone + NADP+ + chloride + H2O
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first step of pentachlorophenol degradation pathway
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ir
pentachlorophenol + NADPH + H+ + O2
tetrachlorohydroquinone + NADP+ + chloride + H2O
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pentachlorophenol degradation
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?
pentachlorophenol + NADPH + H+ + O2
tetrachlorohydroquinone + NADP+ + chloride + H2O
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pentachlorophenol degradation
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?
additional information
?
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biodegradation of the herbicide bromoxynil, i.e. 3,5-dibromo-4-hydroxybenzonitrile
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?
additional information
?
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lateral gene transfer and the origin of the pentachlorophenol pathway, overview
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?
additional information
?
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enzyme expression in response to pentachlorophenol hydroxylase PcpB
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?
additional information
?
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lateral gene transfer and the origin of the pentachlorophenol pathway, overview
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?
additional information
?
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lateral gene transfer and the origin of the pentachlorophenol pathway, overview
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?
