1.14.13.24: 3-hydroxybenzoate 6-monooxygenase
This is an abbreviated version!
For detailed information about 3-hydroxybenzoate 6-monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.24
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1.14.13.24
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gentisate
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flavoprotein
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flavin
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fad
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rhodococcus
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salicylate
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hydroxylases
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jostii
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2,5-dihydroxybenzoate
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maleylpyruvate
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para-hydroxylation
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alcaligenes
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nadh-dependent
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flavin-dependent
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ncimb
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near-uv
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fumarylpyruvate
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nadh-specific
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p-hydroxybenzoate
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regioselective
- 1.14.13.24
- gentisate
- flavoprotein
- flavin
- fad
- rhodococcus
- salicylate
- hydroxylases
- jostii
- 2,5-dihydroxybenzoate
- maleylpyruvate
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para-hydroxylation
- alcaligenes
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nadh-dependent
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flavin-dependent
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ncimb
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near-uv
- fumarylpyruvate
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nadh-specific
- p-hydroxybenzoate
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regioselective
Reaction
Synonyms
3-HBA-6-hydroxylase, 3-hydroxybenzoate 6-hydroxylase, 3-hydroxybenzoate-6-hydroxylase, 3-hydroxybenzoic acid-6-hydroxylase, 3HB6H, m-hydroxybenzoate 6-hydroxylase, MNX2, Mnx2p, NagX, NarX, Ncgl2923, oxygenase, 3-hydroxybenzoate 6-mono-, XlnD
ECTree
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General Information
General Information on EC 1.14.13.24 - 3-hydroxybenzoate 6-monooxygenase
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evolution
metabolism
physiological function
additional information
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evolutionary relationship between the NAD(P)H-dependent FAD-containing 4-hydroxybenzoate hydroxylases and phylogenetic analysis of group A FPMOs, overview
evolution
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sequence comparisons and phylogenetic analysis, phylogenetic tree is constructed with 3-hydroxybenzoate 6-hydroxylases, salicylate 1-hydroxylases and 3-hydroxybenzoate 4-hydroxylases from other 17 strains and confirmed that it is most closely related to 3HB6H from Pseudomonas alcaligenes strain NCIMB 9867
NarX is involved in 3-hydroxybenzoate catabolism, organization of the 3HBA-gentisate catabolic cluster, overview
metabolism
strain ATCC 13032 metabolizes 3-hydroxybenzoate, the 3-hydroxybenzoate 6-hydroxylase is involved in the initial step of 3-hydroxybenzoate catabolismate via gentisate
metabolism
the enzyme catalyzes a key step in the catabolism of lignin-derived aromatic compounds
metabolism
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3-hydroxybenzoate 6-hydroxylase can convert 3-hydroxybenzoate which is an important intermediate in the biodegradation of many aromatic hydrocarbons. 3-Hydroxybenzoate is metabolized by entering the TCA cycle through the gentisate pathway
metabolism
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NarX is involved in 3-hydroxybenzoate catabolism, organization of the 3HBA-gentisate catabolic cluster, overview
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metabolism
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strain ATCC 13032 metabolizes 3-hydroxybenzoate, the 3-hydroxybenzoate 6-hydroxylase is involved in the initial step of 3-hydroxybenzoate catabolismate via gentisate
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the enzyme catalyzes the NADH-dependent conversion of 3-hydroxybenzoate to gentisate
physiological function
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3-hydroxybenzoate 6-hydroxylase, an NADH-dependent flavoprotein, can convert 3-hydroxybenzoate which is an important intermediate in the biodegradation of many aromatic hydrocarbons
physiological function
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the enzyme catalyzes the NADH-dependent conversion of 3-hydroxybenzoate to gentisate
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strain NCIMB 12038 utilizes naphthalene as a sole source of carbon and energy, and degrades naphthalene via salicylate and gentisate. The strain can also use salicylate, i.e. 3-hydroxybenzoate, as sole source of energy and carbon
additional information
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strain NCIMB 12038 utilizes naphthalene as a sole source of carbon and energy, and degrades naphthalene via salicylate and gentisate. The strain can also use salicylate, i.e. 3-hydroxybenzoate, as sole source of energy and carbon
additional information
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3-hydroxybenzoate 6-hydroxylase (3HB6H) structure analysis and comparison with structures of several FAD-dependent 4-hydroxybenzoate hydroxylases, homology modeling, detailed overview. FAD-dependent hydroxybenzoate hydroxylase enzymes structure comparisons
additional information
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residues Tyr221 and Gln305 of 3HB6H from Martelella sp. strain AD-3 are involved in substrate binding
additional information
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strain NCIMB 12038 utilizes naphthalene as a sole source of carbon and energy, and degrades naphthalene via salicylate and gentisate. The strain can also use salicylate, i.e. 3-hydroxybenzoate, as sole source of energy and carbon
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