1.14.13.234: 5a,11a-dehydrotetracycline 5-monooxygenase

This is an abbreviated version!
For detailed information about 5a,11a-dehydrotetracycline 5-monooxygenase, go to the full flat file.

Reaction

Synonyms

12-dehydrotetracycline 5-monooxygenase, anhydrotetracycline oxygenase, OtcC, oxyS

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.234 5a,11a-dehydrotetracycline 5-monooxygenase

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6	AA Sequence
2	Application
1	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
6	General Information
2	Molecular Weight [Da]
9	Organism
5	Pathway
1	Purification (Commentary)
1	Reaction
9	Reference
4	Substrates and Products (Substrate)
1	Subunits
6	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.13.234 - 5a,11a-dehydrotetracycline 5-monooxygenase

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5a,11a-dehydrotetracycline,NADPH:oxygen oxidoreductase (5-hydroxylating)

The enzyme, characterized from the bacterium Streptomyces rimosus, is bifunctional, catalysing two successive monooxygenation reactions. It starts by catalysing the stereospecific hydroxylation of anhydrotetracycline at C-6 (EC 1.14.13.38). If the released product is captured by EC 1.3.98.4, 5a,11a-dehydrotetracycline dehydrogenase (OxyR), it is reduced to tetracycline. However, if the released product is recaptured by OxyS, it performs an additional hydroxylation at C-5, producing 5a,11a-dehydrooxytetracycline, which, following the action of OxyR, becomes oxytetracycline.