1.14.13.231: tetracycline 11a-monooxygenase
This is an abbreviated version!
For detailed information about tetracycline 11a-monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.231
-
1.14.13.231
-
electrocatalytic
-
bacteroides
-
greenhouse
-
electrochemical
-
enzyme-based
-
polyethyleneimine
-
glassy
-
biosensing
-
electrode
-
biosensors
-
thetaiotaomicron
-
dissipation
-
metagenomic
-
degradation
-
biotechnology
-
analysis
- 1.14.13.231
-
electrocatalytic
-
bacteroides
-
greenhouse
-
electrochemical
-
enzyme-based
-
polyethyleneimine
-
glassy
-
biosensing
-
electrode
-
biosensors
- thetaiotaomicron
-
dissipation
-
metagenomic
- degradation
- biotechnology
- analysis
Reaction
Synonyms
BN1088_100004, tetracycline resistance protein from transposon Tn4351/Tn4400, tetracylcine resistance protein TetX, TetX, TetX family tetracycline inactivation enzyme, TetX2
ECTree
1.14.13.231 tetracycline 11a-monooxygenaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 1.14.13.231 - tetracycline 11a-monooxygenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
chlortetracycline + NADPH + H+ + O2
11a-hydroxychlortetracycline + NADP+ + H2O
-
-
-
?
demeclocycline + NADPH + H+ + O2
11a-hydroxydemeclocycline + NADP+ + H2O
-
-
-
?
doxycycline + NADPH + H+ + O2
11a-hydroxydoxycycline + NADP+ + H2O
-
-
-
?
minocycline + NADPH + H+ + O2
11a-hydroxyminocycline + NADP+ + H2O
-
-
-
?
tetracycline + NADPH + H+ + O2
11a-hydroxytetracycline + NADP+ + H2O
-
-
-
?
additional information
?
-
the enzyme shows a broad tetracycline antibiotic spectrum and a requirement for molecular oxygen and NADPH in antibiotic degradation. The tetracycline products are unstable at neutral pH, but mass spectral and NMR characterization under acidic conditions support initial monohydroxylation at position 11a followed by intramolecular cyclization and non-enzymatic breakdown to other undefined products
-
-
?
