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1.14.13.215: protoasukamycin 4-monooxygenase

This is an abbreviated version!
For detailed information about protoasukamycin 4-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.215

Reaction

protoasukamycin
+
NADH
+
H+
+
O2
=
4-hydroxyprotoasukamycin
+
NAD+
+
H2O

Synonyms

asuE1, flavin-dependent protoasukamycin hydroxylase, protoasukamycin 4-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.215 protoasukamycin 4-monooxygenase

Systematic Name

Systematic Name on EC 1.14.13.215 - protoasukamycin 4-monooxygenase

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SYSTEMATIC NAME
IUBMB Comments
protoasukamycin,NADH:oxygen oxidoreductase (4-hydroxylating)
The enzyme, characterized from the bacterium Streptomyces nodosus subsp. asukaensis, is involved in the biosynthesis of the antibiotic asukamycin. Requires a flavin cofactor, with no preference among FMN, FAD or riboflavin. When flavin concentration is low, activity is enhanced by the presence of the NADH-dependent flavin-reductase AsuE2.