1.14.13.211: rifampicin monooxygenase
This is an abbreviated version!
For detailed information about rifampicin monooxygenase, go to the full flat file.
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Synonyms
RIF-O, rifampicin monooxygenase, RifMO, rox
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General Information
General Information on EC 1.14.13.211 - rifampicin monooxygenase
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metabolism
physiological function
RIFMO catalyzes the hydroxylation of rifampicin at the C2 atom followed by cleavage of the ansa linkage, which leads to inactivation of the antibiotic by preventing key contacts with the RNA polymerase target
metabolism
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RIFMO catalyzes the hydroxylation of rifampicin at the C2 atom followed by cleavage of the ansa linkage, which leads to inactivation of the antibiotic by preventing key contacts with the RNA polymerase target
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the enzyme from Rhodococcus equi has the ability to inactivate the antibiotic rifampicin via its decomposition and confers low-level rifampin resistance
physiological function
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the rox gene is capable of initiating rifampicin degradation with another metabolite formation at the first step and having a role as the secondary rifampicin resistance factor in Nocardia farcinica
physiological function
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the rox gene is capable of initiating rifampicin degradation with another metabolite formation at the first step and having a role as the secondary rifampicin resistance factor in Nocardia farcinica
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physiological function
Rhodococcus equi ATCC 14887
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the enzyme from Rhodococcus equi has the ability to inactivate the antibiotic rifampicin via its decomposition and confers low-level rifampin resistance
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