1.14.13.200: tetracenomycin A2 monooxygenase-dioxygenase

This is an abbreviated version!
For detailed information about tetracenomycin A2 monooxygenase-dioxygenase, go to the full flat file.

Reaction

+ 2 O2 + 2 NAD(P)H + 2 H+ =

+ 2 NAD(P)+ +

Synonyms

ElmG, Tcm A2 oxygenase, Tcm B2 oxygenase, TcmG, tetracenomycin A2 oxygenase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.200 tetracenomycin A2 monooxygenase-dioxygenase

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Results	in table
8	AA Sequence
5	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
1	General Information
3	KM Value [mM]
4	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
10	Organism
7	Pathway
2	pH Optimum
1	pH Range
1	pI Value
1	Purification (Commentary)
4	Reaction
8	Reference
1	Specific Activity [micromol/min/mg]
8	Substrates and Products (Substrate)
3	Subunits
8	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

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Reference on EC 1.14.13.200 - tetracenomycin A2 monooxygenase-dioxygenase

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727813

Shen, B.; Hutchinson, C.R.

Triple hydroxylation of tetracenomycin A2 to tetracenomycin C in Streptomyces glaucescens. Overexpression of the tcmG gene in Streptomyces lividans and characterization of the tetracenomycin A2 oxygenase

J. Biol. Chem.

269

30726-30733

1994

Streptomyces glaucescens (Q7M0K6), Streptomyces glaucescens

7982994

728863

Beynon, J.; Rafanan, E.R.; Shen, B.; Fisher, A.J.

Crystallization and preliminary X-ray analysis of tetracenomycin A2 oxygenase: a flavoprotein hydroxylase involved in polyketide biosynthesis

Acta Crystallogr. Sect. D

1647-1651

2000

Streptomyces glaucescens (P39888), Streptomyces glaucescens

11092935

729909

Decker, H.; Motamedi, H.; Hutchinson, C.R.

Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens

J. Bacteriol.

175

3876-3886

1993

Streptomyces glaucescens (P39888)

8509339

730232

Rafanan, E.R.; Le, L.; Zhao, L.; Decker, H.; Shen, B.

Cloning, sequencing, and heterologous expression of the elmGHIJ genes involved in the biosynthesis of the polyketide antibiotic elloramycin from Streptomyces olivaceus Tue2353

J. Nat. Prod.

444-449

2001

Streptomyces olivaceus (Q9L4Y1), Streptomyces olivaceus Tue2353 (Q9L4Y1)

11325225

730547

Rafanan, E.R.; Hutchinson, C.R.; Shen, B.

Triple hydroxylation of tetracenomycin A2 to tetracenomycin C involving two molecules of O2 and one molecule of H2O

Org. Lett.

3225-3227

2000

Streptomyces glaucescens, Streptomyces olivaceus (Q9L4Y1), Streptomyces olivaceus Tue2353 (Q9L4Y1)

11009387