Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.13.182: 2-heptyl-3-hydroxy-4(1H)-quinolone synthase

This is an abbreviated version!
For detailed information about 2-heptyl-3-hydroxy-4(1H)-quinolone synthase, go to the full flat file.

Reaction

2-heptyl-4(1H)-quinolone
+
NADH
+
H+
+
O2
=
2-heptyl-3-hydroxy-4(1H)-quinolone
+
NAD+
+
H2O

Synonyms

2-heptyl-3,4-dihydroxyquinoline synthase, Aqm, PqsH

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.182 2-heptyl-3-hydroxy-4(1H)-quinolone synthase

Substrates Products

Substrates Products on EC 1.14.13.182 - 2-heptyl-3-hydroxy-4(1H)-quinolone synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-heptyl-1-hydroxyquinolin-4(1H)-one + NADH + H+ + O2
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O
show the reaction diagram
2-heptyl-1-hydroxyquinolin-4(1H)-one one + NADH + H+ + O2
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O
show the reaction diagram
2-heptyl-4(1H)-quinolone + NADH + H+ + O2
2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
show the reaction diagram
2-heptyl-4(1H)-quinolone + NADPH + H+ + O2
2-heptyl-3-hydroxy-4(1H)-quinolone + NADP+ + H2O
show the reaction diagram
kcat/KM for NADH is 20fold higher than kcat/Km for NADPH
-
-
?
2-heptylquinolin-4(1H)-one + NADH + H+ + O2
2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
show the reaction diagram
2-nonyl-4(1H)-quinolone + NADH + H+ + O2
3-hydroxy-2-nonyl-4(1H)-quinolone + NAD+ + H2O
show the reaction diagram
the alkyl side chain of 2-heptyl-4-quinolone is critical for PqsH activity with the highest activity observed for alkyl chain lengths of 7 and 9 carbons
-
-
?
2-nonylquinolin-4(1H)-one + NADH + H+ + O2
3-hydroxy-2-nonyl-4(1H)-quinolone + NAD+ + H2O
show the reaction diagram
2-pentyl-4(1H)-quinolone + NADH + H+ + O2
3-hydroxy-2-pentyl-4(1H)-quinolone + NAD+ + H2O
show the reaction diagram
the alkyl side chain of 2-heptyl-4-quinolone is critical for PqsH activity with the highest activity observed for alkyl chain lengths of 7 and 9 carbons
-
-
?
2-pentylquinolin-4(1H)-one + NADH + H+ + O2
3-hydroxy-2-pentyl-4(1H)-quinolone + NAD+ + H2O
show the reaction diagram
2-propyl-4(1H)-quinolone + NADH + H+ + O2
3-hydroxy-2-propyl-4(1H)-quinolone + NAD+ + H2O
show the reaction diagram
the alkyl side chain of 2-heptyl-4-quinolone is critical for PqsH activity with the highest activity observed for alkyl chain lengths of 7 and 9 carbons
-
-
?