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1.14.13.182: 2-heptyl-3-hydroxy-4(1H)-quinolone synthase

This is an abbreviated version!
For detailed information about 2-heptyl-3-hydroxy-4(1H)-quinolone synthase, go to the full flat file.

Reaction

2-heptyl-4(1H)-quinolone
+
NADH
+
H+
+
O2
=
2-heptyl-3-hydroxy-4(1H)-quinolone
+
NAD+
+
H2O

Synonyms

2-heptyl-3,4-dihydroxyquinoline synthase, Aqm, PqsH

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.182 2-heptyl-3-hydroxy-4(1H)-quinolone synthase

Natural Substrates Products

Natural Substrates Products on EC 1.14.13.182 - 2-heptyl-3-hydroxy-4(1H)-quinolone synthase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-heptyl-4(1H)-quinolone + NADH + H+ + O2
2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O
show the reaction diagram
PqsH catalyzes the terminal step in biosynthesis of the Pseudomonas quinolone signal molecule 2-heptyl-3-hydroxy-4(1H)-quinolone. Under anaerobic conditions 2-heptyl-3-hydroxy-4(1H)-quinolone is not produced. The enzyme is a biochemical regulator of Pseudomonas quinolone signal controlled social behaviors in Pseudomonas aeruginosa
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