1.14.12.11: toluene dioxygenase
This is an abbreviated version!
For detailed information about toluene dioxygenase, go to the full flat file.
Word Map on EC 1.14.12.11
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1.14.12.11
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putida
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naphthalene
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trichloroethylene
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ethylbenzene
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chlorobenzene
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cis-dihydrodiols
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dihydrodiols
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cis-dihydroxylation
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dot-t1e
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ring-hydroxylating
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cis-toluene
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indene
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cis-diols
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pseudoalcaligenes
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1-indanone
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toluene-grown
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3-methylcatechol
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synthesis
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analysis
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degradation
- 1.14.12.11
- putida
- naphthalene
- trichloroethylene
- ethylbenzene
- chlorobenzene
- cis-dihydrodiols
- dihydrodiols
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cis-dihydroxylation
- dot-t1e
-
ring-hydroxylating
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cis-toluene
- indene
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cis-diols
- pseudoalcaligenes
- 1-indanone
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toluene-grown
- 3-methylcatechol
- synthesis
- analysis
- degradation
Reaction
Synonyms
ISPTOD, ISPTOL, More, oxygenase, toluene 2,3-di-, oxygenaseTOL, TDO, Tod, todC1C2BA, toluene 2,3-dioxygenase
ECTree
1.14.12.11 toluene dioxygenaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.14.12.11 - toluene dioxygenase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-cresol + NADH + H+ + O2
?
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activity in strain UV4formation of the corresponding cis-diol and catechol
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?
4-xylene + NADH + H+ + O2
4-xylenol + NAD+ + H2O
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activity in strain 39/D
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-
?
benzene + NADH + O2
benzene dihydrodiol + NAD+
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involved in the conversion of aromatic compounds to their corresponding catechols
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-
?
ethylbenzene + NADH + O2
?
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involved in the conversion of aromatic compounds to their corresponding catechols
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-
?
indole + NADH + H+ + O2
2,2'-bis(2,3-dihydro-3-oxoindolyliden) + NAD+
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toluene dioxygenase is ubiquitous in nature and has a broad substrate range, including benzene, toluene, ethylbenzene and xylenes. The organism produces indigo from indole through the activity of TDO
i.e. indigo
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?
xylene + NADH + O2
?
-
involved in the conversion of aromatic compounds to their corresponding catechols
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-
?
toluene + NADH + H+ + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
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-
-
-
?
toluene + NADH + H+ + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
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-
-
?
toluene + NADH + H+ + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
-
-
?
toluene + NADH + H+ + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
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-
-
-
?
toluene + NADH + H+ + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
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-
-
-
?
toluene + NADH + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
-
-
-
?
toluene + NADH + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
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initial enzyme of toluene catabolism
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-
?
toluene + NADH + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
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enzyme is involved in meta pathway for catechol degradation
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-
?
toluene + NADH + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
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involved in the conversion of aromatic compounds to their corresponding catechols
-
-
?
toluene + NADH + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
initial enzyme of toluene catabolism
-
-
?
toluene + NADH + O2
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
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-
-
-
?
additional information
?
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the enzyme is organized in a multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system. The TDO system is composed of a reductase, TDO-R, a Rieske [2Fe2S] ferredoxin, TDO-F, and a terminal dioxygenase, TDO-O, overview. TDO-F shuttles electrons from NADH via a flavin in TDO-R to TDO-O, which catalyzes the enantioselective addition of dioxygen to the aromatic nucleus to form cis-(1R,2S)-dihydroxy-3-methylcyclohexa-3,5-diene
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-
?
additional information
?
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TodS exhibits basal autophosphorylation activity that increases in the presence of toluene and is translated as an increase in the rate of transphosphorylation of TodT
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?
