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1.14.11.57: L-proline trans-4-hydroxylase

This is an abbreviated version!
For detailed information about L-proline trans-4-hydroxylase, go to the full flat file.

Reaction

L-proline
+
2-oxoglutarate
+
O2
=
trans-4-hydroxy-L-proline
+
succinate
+
CO2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.57 L-proline trans-4-hydroxylase

Inhibitors

Inhibitors on EC 1.14.11.57 - L-proline trans-4-hydroxylase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-oxoglutarate
-
inhibitory above 0.5 mM
3,4-dihydroxybenzoate
-
-
Co2+
-
0.5 mM, complete inhibition
diethyl dicarbonate
-
complete inhibition. Inactivation can be partially prevented by the inclusion of L-proline and 2-oxoglutarate in the preincubation mixture
L-ascorbate
-
ascorbate causes a time-dependent inhibition of L-proline hydroxylation. The addition of ascorbate does not stimulate L-proline-coupled turnover of 2-oxoglutarate, but does stimulate L-proline-uncoupled turnover
Pyridine-2,4-dicarboxylate
-
competitive with respect to 2-oxoglutarate
Pyridine-2,5-dicarboxylate
-
-
Zn2+
-
0.5 mM, complete inhibition