1.14.11.57: L-proline trans-4-hydroxylase
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For detailed information about L-proline trans-4-hydroxylase, go to the full flat file.
Reaction
ECTree
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Inhibitors
Inhibitors on EC 1.14.11.57 - L-proline trans-4-hydroxylase
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diethyl dicarbonate
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complete inhibition. Inactivation can be partially prevented by the inclusion of L-proline and 2-oxoglutarate in the preincubation mixture
L-ascorbate
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ascorbate causes a time-dependent inhibition of L-proline hydroxylation. The addition of ascorbate does not stimulate L-proline-coupled turnover of 2-oxoglutarate, but does stimulate L-proline-uncoupled turnover
Pyridine-2,4-dicarboxylate
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competitive with respect to 2-oxoglutarate