1.14.11.56: L-proline cis-4-hydroxylase
This is an abbreviated version!
For detailed information about L-proline cis-4-hydroxylase, go to the full flat file.
Word Map on EC 1.14.11.56
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1.14.11.56
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cis-4-hydroxy-l-proline
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sinorhizobium
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meliloti
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dioxygenase
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hydroxylases
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regioselectivity
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loti
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chop
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non-heme
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mesorhizobium
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synthesis
- 1.14.11.56
- cis-4-hydroxy-l-proline
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sinorhizobium
- meliloti
- dioxygenase
- hydroxylases
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regioselectivity
- loti
-
chop
-
non-heme
-
mesorhizobium
- synthesis
Reaction
Synonyms
cis-P4H, L-proline cis-4-hydroxylase, MlP4H, mlr6283, R03107, SmP4H
ECTree
1.14.11.56 L-proline cis-4-hydroxylaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.14.11.56 - L-proline cis-4-hydroxylase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-homophenylalanine + 2-oxoglutarate + O2
? + succinate + CO2
mutant enzyme W40M shows 8.3fold increase in turnover number for L-homophenylalanine as compared to wild-type enzyme and mutant enzyme W40M/I103L shows 112fold increase in turnover number. Mutation reprograms the natural hydroxylase to predominantly act as a desaturase, giving almost exclusively 3,4-desaturated L-homophenylalanine, through capability of tyrosine to serve as a catalytic entity in the reaction mechanism
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-
?
L-pipecolate + 2-oxoglutarate + O2
cis-5-hydroxypipecolate + cis-3-hydroxypipecolate + succinate + CO2
L-pipecolic acid + 2-oxoglutarate + O2
cis-5-hydroxy-L-pipecolic acid + cis-3-hydroxy-L-pipecolic acid + succinate + CO2
L-pipecolate + 2-oxoglutarate + O2
cis-5-hydroxypipecolate + cis-3-hydroxypipecolate + succinate + CO2
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-
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?
L-pipecolate + 2-oxoglutarate + O2
cis-5-hydroxypipecolate + cis-3-hydroxypipecolate + succinate + CO2
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-
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?
L-pipecolic acid + 2-oxoglutarate + O2
cis-5-hydroxy-L-pipecolic acid + cis-3-hydroxy-L-pipecolic acid + succinate + CO2
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the ratio between cis-5/cis-3 isomers is about 1:7
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?
L-pipecolic acid + 2-oxoglutarate + O2
cis-5-hydroxy-L-pipecolic acid + cis-3-hydroxy-L-pipecolic acid + succinate + CO2
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the ratio between cis-5/cis-3 isomers is about 2:1
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?
L-pipecolic acid + 2-oxoglutarate + O2
cis-5-hydroxy-L-pipecolic acid + cis-3-hydroxy-L-pipecolic acid + succinate + CO2
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the ratio between cis-5/cis-3 isomers is about 2:1
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?
L-pipecolic acid + 2-oxoglutarate + O2
cis-5-hydroxy-L-pipecolic acid + cis-3-hydroxy-L-pipecolic acid + succinate + CO2
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the ratio between cis-5/cis-3 isomers is about 1:7
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?
L-proline + 2-oxoglutarate + O2
cis-4-hydroxy-L-proline + succinate + CO2
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-
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?
L-proline + 2-oxoglutarate + O2
cis-4-hydroxy-L-proline + succinate + CO2
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-
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?
L-proline + 2-oxoglutarate + O2
cis-4-hydroxy-L-proline + succinate + CO2
presence of 2-oxoglutarate is strictly required
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?
L-proline + 2-oxoglutarate + O2
cis-4-hydroxy-L-proline + succinate + CO2
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-
-
?
L-proline + 2-oxoglutarate + O2
cis-4-hydroxy-L-proline + succinate + CO2
presence of 2-oxoglutarate is strictly required
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-
?
L-proline + 2-oxoglutarate + O2
cis-4-hydroxy-L-proline + succinate + CO2
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-
-
?
L-proline + 2-oxoglutarate + O2
cis-4-hydroxy-L-proline + succinate + CO2
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-
-
?
L-proline + 2-oxoglutarate + O2
cis-4-hydroxy-L-proline + succinate + CO2
presence of 2-oxoglutarate is strictly required
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-
?
L-proline + 2-oxoglutarate + O2
cis-4-hydroxy-L-proline + succinate + CO2
acceptance of the native substrate L-proline is almost completely abolished in the mutant enzymes W40M und W40M/I103L
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?
