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1.14.11.54: mRNA N1-methyladenine demethylase

This is an abbreviated version!
For detailed information about mRNA N1-methyladenine demethylase, go to the full flat file.

Word Map on EC 1.14.11.54

Reaction

N1-methyladenine in mRNA
+
2-oxoglutarate
 +
O2
=
adenine in mRNA
 +
formaldehyde
 +
succinate
 +
CO2

Synonyms

ABH3, AlkB, AlkB homolog 3, ALKBH3, alpha-ketoglutarate-dependent dioxygenase alkB homolog 3, PCA-1, prostate cancer antigen-1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.54 mRNA N1-methyladenine demethylase

Crystallization

Crystallization on EC 1.14.11.54 - mRNA N1-methyladenine demethylase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
structure of the ABH3 catalytic core in complex with iron and 2-oxoglutarate at 1.5 A resolution. The ABH3 structure reveals the beta-strand jelly-roll fold that coordinates a catalytically active iron centre by a conserved His1-X-Asp/Glu-Xn-His2 motif. The structure shows a positively charged DNA/RNA binding groove and a flexible hairpin involved in nucleotide flipping and ss/ds-DNA discrimination, and reveals self-hydroxylation of an active site leucine