1.14.11.53: mRNA N6-methyladenine demethylase
This is an abbreviated version!
For detailed information about mRNA N6-methyladenine demethylase, go to the full flat file.
Word Map on EC 1.14.11.53
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1.14.11.53
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demethylation
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demethylases
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mettl14
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reader
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writer
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erasers
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ythdf1
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methyltransferases
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epitranscriptomic
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m6a-related
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fto-mediated
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m6a-dependent
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hnrnpa2b1
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methyltransferase-like
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hnrnpc
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lasso
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m6a-modified
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igf2bp1
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merip
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merip-seq
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m6a-binding
- 1.14.11.53
-
demethylation
- demethylases
- mettl14
-
reader
-
writer
-
erasers
-
ythdf1
- methyltransferases
-
epitranscriptomic
-
m6a-related
-
fto-mediated
-
m6a-dependent
-
hnrnpa2b1
-
methyltransferase-like
-
hnrnpc
-
lasso
-
m6a-modified
-
igf2bp1
-
merip
-
merip-seq
-
m6a-binding
Reaction
Synonyms
AlkB homolog 5, ALKBH10B, ALKBH5, ALKBH5 demethylase, ALKBH9B, alkylation repair homolog protein 5, fat mass and obesity-associated enzyme, fat mass and obesity-associated protein, FTO, m6A mRNA demethylase, m6A RNA demethylase, m6A-RNA demethylase, N6-methyladenosine demethylase, RNA N6-methyladenine demethylase
ECTree
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Reference on EC 1.14.11.53 - mRNA N6-methyladenine demethylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jia, G.; Yang, C.G.; Yang, S.; Jian, X.; Yi, C.; Zhou, Z.; He, C.
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO
FEBS Lett.
582
3313-3319
2008
Mus musculus (Q8BGW1), Homo sapiens (Q9C0B1)
Aik, W.; Scotti, J.S.; Choi, H.; Gong, L.; Demetriades, M.; Schofield, C.J.; McDonough, M.A.
Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation
Nucleic Acids Res.
42
4741-4754
2014
Homo sapiens (Q6P6C2), Homo sapiens
Zhou, B.; Han, Z.
Crystallization and preliminary X-ray diffraction of the RNA demethylase ALKBH5
Acta Crystallogr. Sect. F
69
1231-1234
2013
Homo sapiens
Zhu, C.; Yi, C.
Switching demethylation activities between AlkB family RNA/DNA demethylases through exchange of active-site residues
Angew. Chem. Int. Ed. Engl.
53
3659-3662
2014
Homo sapiens
Liu, K.; Ding, Y.; Ye, W.; Liu, Y.; Yang, J.; Liu, J.; Qi, C.
Structural and functional characterization of the proteins responsible for N6-methyladenosine modification and recognition
Curr. Protein Pept. Sci.
17
306-318
2016
Homo sapiens
Chen, W.; Zhang, L.; Zheng, G.; Fu, Y.; Ji, Q.; Liu, F.; Chen, H.; He, C.
Crystal structure of the RNA demethylase ALKBH5 from zebrafish
FEBS Lett.
588
892-898
2014
Danio rerio (Q08BA6), Danio rerio
Landfors, M.; Nakken, S.; Fusser, M.; Dahl, J.A.; Klungland, A.; Fedorcsak, P.
Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations
Fertil. Steril.
105
1170-1179
2016
Homo sapiens
Feng, C.; Liu, Y.; Wang, G.; Deng, Z.; Zhang, Q.; Wu, W.; Tong, Y.; Cheng, C.; Chen, Z.
Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition
J. Biol. Chem.
289
11571-11583
2014
Homo sapiens (Q6P6C2), Homo sapiens
Xu, C.; Liu, K.; Tempel, W.; Demetriades, M.; Aik, W.; Schofield, C.J.; Min, J.
Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation
J. Biol. Chem.
289
17299-17311
2014
Homo sapiens (Q6P6C2), Homo sapiens
Li, F.; Kennedy, S.; Hajian, T.; Gibson, E.; Seitova, A.; Xu, C.; Arrowsmith, C.H.; Vedadi, M.
A Radioactivity-based assay for screening human m6A-RNA methyltransferase, METTL3-METTL14 complex, and demethylase ALKBH5
J. Biomol. Screen.
21
290-297
2016
Homo sapiens
Shen, F.; Huang, W.; Huang, J.T.; Xiong, J.; Yang, Y.; Wu, K.; Jia, G.F.; Chen, J.; Feng, Y.Q.; Yuan, B.F.; Liu, S.M.
Decreased N6-methyladenosine in peripheral blood RNA from diabetic patients is associated with FTO expression rather than ALKBH5
J. Clin. Endocrinol. Metab.
100
E148-E154
2015
Homo sapiens
Zheng, G.
Dahl, J.A.; Niu, Y.; Fedorcsak, P.; Huang, C.M.; Li, C.J.; Vagbo, C.B.; Shi, Y.; Wang, W.L.; Song, S.H.; Lu, Z.; Bosmans, R.P.; Dai, Q.; Hao, Y.J.; Yang, X.; Zhao, W.M.; Tong, W.M.; Wang, X.J.; Bogdan, F.; Furu, K.; Fu, Y.; Jia, G.; Zhao, X.; Liu, J.; Krokan, H.E.; Klungland, A.; Yang, Y.G.; He, C.: ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
Mol. Cell
49
18-29
2013
Mus musculus (Q3TSG4), Mus musculus, Homo sapiens (Q6P6C2)
Jia, G.; Fu, Y.; Zhao, X.; Dai, Q.; Zheng, G.; Yang, Y.; Yi, C.; Lindahl, T.; Pan, T.; Yang, Y.G.; He, C.
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Nat. Chem. Biol.
7
885-887
2011
Homo sapiens (Q9C0B1), Homo sapiens
Han, Z.; Niu, T.; Chang, J.; Lei, X.; Zhao, M.; Wang, Q.; Cheng, W.; Wang, J.; Feng, Y.; Chai, J.
Crystal structure of the FTO protein reveals basis for its substrate specificity
Nature
464
1205-1209
2010
Homo sapiens (Q9C0B1)
Huang, Y.; Yan, J.; Li, Q.; Li, J.; Gong, S.; Zhou, H.; Gan, J.; Jiang, H.; Jia, G.F.; Luo, C.; Yang, C.G.
Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5
Nucleic Acids Res.
43
373-384
2015
Homo sapiens (Q6P6C2), Homo sapiens
Zhang, C.; Samanta, D.; Lu, H.; Bullen, J.W.; Zhang, H.; Chen, I.; He, X.; Semenza, G.L.
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA
Proc. Natl. Acad. Sci. USA
113
E2047-E2056
2016
Homo sapiens
Zou, S.; Toh, J.D.; Wong, K.H.; Gao, Y.G.; Hong, W.; Woon, E.C.
N6-methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
Sci. Rep.
6
25677
2016
Homo sapiens
Chandola, U.; Das, R.; Panda, B.
Role of the N6-methyladenosine RNA mark in gene regulation and its implications on development and disease
Brief. Funct. Genomics
14
169-179
2015
Homo sapiens
Liu, K.; Ding, Y.; Ye, W.; Liu, Y.; Yang, J.; Liu, J.; Qi, C.
Structural and functional characterization of the proteins responsible for N6-methyladenosine modification and recognition
Curr. Protein Pept. Sci.
17
306-318
2015
Homo sapiens
Ye, F.; Zhang, L.; Jin, L.; Zheng, M.; Jiang, H.; Luo, C.
Repair of methyl lesions in RNA by oxidative demethylation
MedChemComm
5
1797-1803
2014
Homo sapiens
-
Bartosovic, M.; Molares, H.C.; Gregorova, P.; Hrossova, D.; Kudla, G.; Vanacova, S.
N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3-end processing
Nucleic Acids Res.
45
11356-11370
2017
Homo sapiens
Berulava, T.; Rahmann, S.; Rademacher, K.; Klein-Hitpass, L.; Horsthemke, B.
N6-adenosine methylation in miRNAs
PLoS ONE
10
e0118438
2015
Homo sapiens
Yang, Y.; Huang, W.; Huang, J.T.; Shen, F.; Xiong, J.; Yuan, E.F.; Qin, S.S.; Zhang, M.; Feng, Y.Q.; Yuan, B.F.; Liu, S.M.
Increased N6-methyladenosine in human sperm RNA as a risk factor for asthenozoospermia
Sci. Rep.
6
24345
2016
Homo sapiens
Selberg, S.; Seli, N.; Kankuri, E.; Karelson, M.
Rational design of novel anticancer small-molecule RNA m6A demethylase ALKBH5 inhibitors
ACS Omega
6
13310-13320
2021
Homo sapiens (Q6P6C2)
Zhang, Y.; Li, Q.N.; Zhou, K.; Xu, Q.; Zhang, C.Y.
Identification of specific N6-methyladenosine RNA demethylase FTO inhibitors by single-quantum-dot-based FRET nanosensors
Anal. Chem.
92
13936-13944
2020
Homo sapiens (Q6P6C2), Homo sapiens (Q9C0B1), Homo sapiens
Xie, L.J.; Yang, X.T.; Wang, R.L.; Cheng, H.P.; Li, Z.Y.; Liu, L.; Mao, L.; Wang, M.; Cheng, L.
Identification of flavin mononucleotide as a cell-active artificial N6-methyladenosine RNA demethylase
Angew. Chem. Int. Ed. Engl.
58
5028-5032
2019
synthetic construct
Li, J.; Han, Y.; Zhang, H.; Qian, Z.; Jia, W.; Gao, Y.; Zheng, H.; Li, B.
The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA
Biochem. Biophys. Res. Commun.
512
479-485
2019
Homo sapiens (Q9C0B1)
Tsuruta, N.; Tsuchihashi, K.; Ohmura, H.; Yamaguchi, K.; Ito, M.; Ariyama, H.; Kusaba, H.; Akashi, K.; Baba, E.
RNA N6-methyladenosine demethylase FTO regulates PD-L1 expression in colon cancer cells
Biochem. Biophys. Res. Commun.
530
235-239
2020
Homo sapiens (Q9C0B1)
Du, T.; Li, G.; Yang, J.; Ma, K.
RNA demethylase Alkbh5 is widely expressed in neurons and decreased during brain development
Brain Res. Bull.
163
150-159
2020
Mus musculus (Q3TSG4), Mus musculus
Jiang, Z.X.; Wang, Y.N.; Li, Z.Y.; Dai, Z.H.; He, Y.; Chu, K.; Gu, J.Y.; Ji, Y.X.; Sun, N.X.; Yang, F.; Li, W.
The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging
Cell Death Dis.
12
744
2021
Homo sapiens (Q9C0B1), Homo sapiens
Feng, L.; Fan, Y.; Zhou, J.; Li, S.; Zhang, X.
The RNA demethylase ALKBH5 promotes osteoblast differentiation by modulating Runx2 mRNA stability
FEBS Lett.
595
2007-2014
2021
Rattus norvegicus (D3ZKD3)
Martinez-Perez, M.; Gomez-Mena, C.; Alvarado-Marchena, L.; Nadi, R.; Micol, J.L.; Pallas, V.; Aparicio, F.
The m6A RNA Demethylase ALKBH9B plays a critical role for vascular movement of alfalfa mosaic virus in Arabidopsis
Front. Microbiol.
12
745576
2021
Arabidopsis thaliana (Q9SL49)
Alvarado-Marchena, L.; Marquez-Molins, J.; Martinez-Perez, M.; Aparicio, F.; Pallas, V.
Mapping of functional subdomains in the atALKBH9B m6A-demethylase required for its binding to the viral RNA and to the coat protein of alfalfa mosaic virus
Front. Plant Sci.
12
701683
2021
Arabidopsis thaliana (Q9SL49)
Tang, J.; Yang, J.; Duan, H.; Jia, G.
ALKBH10B, an mRNA m6A demethylase, modulates ABA response during seed germination in Arabidopsis
Front. Plant Sci.
12
712713
2021
Arabidopsis thaliana (Q9ZT92)
Zhang, J.; Guo, S.; Piao, H.; Wang, Y.; Wu, Y.; Meng, X.; Yang, D.; Zheng, Z.; Zhao, Y.
ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1
J. Physiol. Biochem.
75
379-389
2019
Homo sapiens (Q6P6C2)
Niu, Y.; Lin, Z.; Wan, A.; Chen, H.; Liang, H.; Sun, L.; Wang, Y.; Li, X.; Xiong, X.F.; Wei, B.; Wu, X.; Wan, G.
RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
Mol. Cancer
18
46
2019
Homo sapiens (Q9C0B1), Homo sapiens
Yue, B.; Cui, R.; Zheng, R.; Jin, W.; Song, C.; Bao, T.; Wang, M.; Yu, F.; Zhao, E.
Essential role of ALKBH5-mediated RNA demethylation modification in bile acid-induced gastric intestinal metaplasia
Mol. Ther. Nucleic Acids
26
458-472
2021
Homo sapiens (Q6P6C2)
Yang, S.; Wei, J.; Cui, Y.H.; Park, G.; Shah, P.; Deng, Y.; Aplin, A.E.; Lu, Z.; Hwang, S.; He, C.; He, Y.Y.
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
Nat. Commun.
10
2782
2019
Mus musculus (Q8BGW1), Homo sapiens (Q9C0B1), Homo sapiens
Yu, F.; Wei, J.; Cui, X.; Yu, C.; Ni, W.; Bungert, J.; Wu, L.; He, C.; Qian, Z.
Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response
Nucleic Acids Res.
49
5779-5797
2021
Homo sapiens (Q6P6C2)
Toh, J.; Crossley, S.; Bruemmer, K.; Ge, E.; He, D.; Iovan, D.; Chang, C.
Distinct RNA N-demethylation pathways catalyzed by nonheme iron ALKBH5 and FTO enzymes enable regulation of formaldehyde release rates
Proc. Natl. Acad. Sci. USA
117
25284-25292
2020
Homo sapiens (Q6P6C2), Homo sapiens (Q9C0B1)
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