1.14.11.33: DNA oxidative demethylase

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For detailed information about DNA oxidative demethylase, go to the full flat file.

Word Map on EC 1.14.11.33

1.14.11.33

demethylation

3-methylcytosine

wobble

1,n6-ethenoadenine

alkbhs

2-oxoglutarate-dependent

dealkylation

writer

etheno

epitranscriptomic

5-methoxycarbonylmethyluridine

n1-methyladenosine

n6-methyladenine

analysis

Reaction

Synonyms

1-methyladenine-DNA dioxygenase, ABH1, ABH2, ABH3, AlkB, AlkB homolog 1, ALKBH2, ALKBH3, ALKBH8, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, FTO

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.33 DNA oxidative demethylase

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1	Activating Compound
1770	AA Sequence
1	Application
28	Cloned(Commentary)
28	Cofactor
1	Crystallization (Commentary)
188	Disease/ Diagnostics
26	General Information
1	IC50 Value
3	Inhibitors
11	kcat/KM [mM/s]
14	KM Value [mM]
8	Localization
41	Metals/Ions
53	Natural Substrates/ Products (Substrates)
105	Organism
20	PDB ID
6	pH Optimum
32	Protein Variants
24	Purification (Commentary)
1	Reaction
16	Reaction Type
54	Reference
12	Source Tissue
1	Storage Stability
256	Substrates and Products (Substrate)
82	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
13	Turnover Number [1/s]

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Systematic Name on EC 1.14.11.33 - DNA oxidative demethylase

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methyl DNA-base, 2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming)

Contains iron; activity is slightly stimulated by ascorbate. Catalyses oxidative demethylation of the DNA base lesions N1-methyladenine, N3-methylcytosine, N1-methylguanine, and N3-methylthymine. It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.