1.14.11.33: DNA oxidative demethylase

This is an abbreviated version!
For detailed information about DNA oxidative demethylase, go to the full flat file.

Reaction

Synonyms

1-methyladenine-DNA dioxygenase, ABH1, ABH2, ABH3, AlkB, AlkB homolog 1, ALKBH2, ALKBH3, ALKBH8, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, FTO

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.33 DNA oxidative demethylase

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Results	in table
1	Activating Compound
1770	AA Sequence
1	Application
28	Cloned(Commentary)
28	Cofactor
1	Crystallization (Commentary)
188	Disease/ Diagnostics
26	General Information
1	IC50 Value
3	Inhibitors
11	kcat/KM [mM/s]
14	KM Value [mM]
8	Localization
41	Metals/Ions
53	Natural Substrates/ Products (Substrates)
105	Organism
20	PDB ID
6	pH Optimum
32	Protein Variants
24	Purification (Commentary)
1	Reaction
16	Reaction Type
54	Reference
12	Source Tissue
1	Storage Stability
256	Substrates and Products (Substrate)
82	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
13	Turnover Number [1/s]

KM Value

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KM Value on EC 1.14.11.33 - DNA oxidative demethylase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0004

1-methyl-adenine in 5'-dAAAA-1MeA-YYAAA

Homo sapiens

-

pH not specified in the publication, temperature not specified in the publication

740580

0.002

1-methyl-dAMP

Escherichia coli

-

apparent value, at 37°C, pH not specified in the publication

715464

0.0055

1-methyl-dATP

Escherichia coli

-

apparent value, at 37°C, pH not specified in the publication

715464

0.012

2'-deoxy-1-methyl-adenosine 3'-phosphate

Escherichia coli

-

apparent value, at 37°C, pH not specified in the publication

715464

0.0044 - 0.05

d(Tpm1A)

2 entries

0.0028

d(Tpm1ApT)

Escherichia coli

-

apparent value, at 37°C, pH not specified in the publication

715464

0.002

DNA-N1-methyladenine

Escherichia coli

P05050

wild type enzyme, pH and temperature not specified in the publication

741601

-

0.0062

double-stranded DNA-1-methyladenine

Escherichia coli

-

at 25°C, pH not specified in the publication

716367

-

0.0093

double-stranded DNA-3-methylcytosine

Escherichia coli

-

at 25°C, pH not specified in the publication

716367

-

0.01

N1-methyl-ATP

Escherichia coli

-

apparent value, at 37°C, pH not specified in the publication

715464

0.0014

poly(dm1A)

Escherichia coli

-

apparent value, at 37°C, pH not specified in the publication

715464

-

0.0054

single-stranded DNA-1-methyladenine

Escherichia coli

-

at 25°C, pH not specified in the publication

716367

-

0.0034

single-stranded DNA-3-methylcytosine

Escherichia coli

-

at 25°C, pH not specified in the publication

716367

-

0.0044

d(Tpm1A)

Escherichia coli

-

apparent value, at 37°C, pH not specified in the publication

715464

0.04 - 0.05

d(Tpm1A)

Escherichia coli

-

apparent value, at 37°C, pH not specified in the publication

715464