1.14.11.32: codeine 3-O-demethylase
This is an abbreviated version!
For detailed information about codeine 3-O-demethylase, go to the full flat file.
Word Map on EC 1.14.11.32
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1.14.11.32
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thebaine
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morphine
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poppy
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opium
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papaver
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somniferum
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benzylisoquinoline
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o-demethylation
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codeinone
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morphinans
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virus-induced
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analgesics
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dioxygenases
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acinetobacter
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narcotic
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opiate
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salutaridinol
- 1.14.11.32
- thebaine
- morphine
- poppy
-
opium
-
papaver
- somniferum
-
benzylisoquinoline
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o-demethylation
- codeinone
-
morphinans
-
virus-induced
-
analgesics
- dioxygenases
- acinetobacter
-
narcotic
-
opiate
- salutaridinol
Reaction
Synonyms
codeine O-demethylase, codeine-O-demethylase, CODM
ECTree
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Substrates Products
Substrates Products on EC 1.14.11.32 - codeine 3-O-demethylase
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REACTION DIAGRAM
(R,S)-tetrahydropalmatine + 2-oxoglutarate + O2
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a protoberberine, O-demethylation, 16.6% of activity with protopine
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(S)-isocorydine + 2-oxoglutarate + O2
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a aporphine, O-demethylation, 6.1% of activity with protopine
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(S)-reticuline + 2-oxoglutarate + O2
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a 1-benzylisoquinoline, O-demethylation, 16.2% of activity with protopine
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(S)-scoulerine + 2-oxoglutarate + O2
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a 1-benzylisoquinoline, O-demethylation, 70.4% of activity with protopine
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allocryptopine + 2-oxoglutarate + O2
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a protopine, O-demethylation, 50.1% of activity with protopine
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cryptopine + 2-oxoglutarate + O2
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a protopine, O-demethylation, 37.7% of activity with protopine
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neopine + 2-oxoglutarate + O2
neomorphine + formaldehyde + succinate + CO2
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O-demethylcryptopine + 2-oxoglutarate + O2
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a protopine, O-demethylation, 40.8% of activity with protopine
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scoulerine + 2-oxoglutarate + O2
3-O-demethylscoulerine + formaldehyde + succinate + CO2
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120% of the activity with codeine
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thebaine + 2-oxoglutarate + O2
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a morphinan, O-demethylation, 80.5% of activity with protopine
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additional information
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no activity with (S)-reticuline, papaverine, (S)-corytuberine, pavine, salutaridine, oripavine, noscapine
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morphine + formaldehyde + succinate + CO2
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codeine + 2-oxoglutarate + O2
morphine + formaldehyde + succinate + CO2
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codeine + 2-oxoglutarate + O2
morphine + formaldehyde + succinate + CO2
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alkyl hydroxylation proceeds through a radical mechanism involving an iron-oxo intermediate, followed by the elimination of formaldehyde
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codeine + 2-oxoglutarate + O2
morphine + formaldehyde + succinate + CO2
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a morphinan, O-demethylation, 89.8% of activity with protopine
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oripavine + formaldehyde + succinate + CO2
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thebaine + 2-oxoglutarate + O2
oripavine + formaldehyde + succinate + CO2
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thebaine + 2-oxoglutarate + O2
oripavine + formaldehyde + succinate + CO2
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25% of the activity with codeine. Alkyl hydroxylation proceeds through a radical mechanism involving an iron-oxo intermediate, followed by the elimination of formaldehyde
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