1.14.11.21: clavaminate synthase
This is an abbreviated version!
For detailed information about clavaminate synthase, go to the full flat file.
Word Map on EC 1.14.11.21
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1.14.11.21
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clavulanic
-
clavuligerus
-
alpha-ketoglutarate
-
proclavaminic
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beta-lactamase
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dioxygenase
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non-heme
-
cs2
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oxygenases
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clavams
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dioxygen
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alpha-ketoglutarate-dependent
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desaturation
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amidinohydrolase
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2-his-1-carboxylate
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synthesis
- 1.14.11.21
-
clavulanic
- clavuligerus
- alpha-ketoglutarate
-
proclavaminic
- beta-lactamase
- dioxygenase
-
non-heme
- cs2
- oxygenases
-
clavams
- dioxygen
-
alpha-ketoglutarate-dependent
-
desaturation
-
amidinohydrolase
-
2-his-1-carboxylate
- synthesis
Reaction
Synonyms
CAS, CAS1, CAS2, clavaminate synthase 1, clavaminate synthase 2, clavaminic acid synthase, CS, synthase, clavaminate
ECTree
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Metals Ions
Metals Ions on EC 1.14.11.21 - clavaminate synthase
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Fe2+
Fe2+
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required
Fe2+
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1 ion per catalytically active enzyme molecule for the cyclization and the saturation reaction
Fe2+
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isozyme CS2, five and six-coordinate ferrous species in the enzyme-substrate complexes, structural model of conversion for the different reactions
Fe2+
isozyme CS2, five and six-coordinate ferrous species in the enzyme-substrate complexes, structural model of conversion for the different reactions
Fe2+
-
no ligand switching among the histidine residues of the protein
Fe2+
-
H145 forms part of the HXE iron-binding motif in isozyme CAS2
Fe2+
required, residues H183, D185, and H243 are involved in Fe2+-binding