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1.14.11.2: procollagen-proline 4-dioxygenase

This is an abbreviated version!
For detailed information about procollagen-proline 4-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.2

Reaction

Procollagen L-proline
+
2-oxoglutarate
 +
O2
=
procollagen trans-4-hydroxy-L-proline
 +
succinate
 +
CO2

Synonyms

A085R, alpha (I) subunit, anthrax-P4H, AT-P4H-1, At-P4H-2, BaP4H, C-P4H, C-P4H alpha subunit (III), C-P4H alpha(I), C-P4H alpha(III), CePHY-1/PHY-2/PDI2, collagen proline hydroxylase, collagen prolyl 4-hydroxylase, collagen prolyl 4-hydroxylase (type-II), collagen prolyl 4-hydroxylase 1, collagen prolyl-4-hydroxylase, collagen prolyl-4-hydroxylase alpha subunit 2, CP4H, CP4H1, CrP4H-1, DmP4H, egg-laying abnormal-9 prolyl hydroxylase, Egl nine homolog, EGLN, EGLN prolyl hydroxylase, EGLN3, EGLN3 hydroxylase, GBAA_4459, HIF prolyl hydroxylase, HIF prolyl-4-hydroxylase, HIF-1alpha-specific prolyl-hydroxylase, HIF-P4H-1, HIF-P4H-2, HIF-P4H-3, HPH, HPH-2, HuPH4-I, HuPH4-II, hydroxylase, collagen proline, hypoxia inducible factor prolyl-4-hydroxylase domain-containing protein, hypoxia inducible factor-prolyl hydroxylase, hypoxia-inducible factor -1alpha-type prolyl 4-hydroxylase, hypoxia-inducible factor prolyl hydroxylase, hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2, More, NtP4H1.1, P4H, P4H alpha1, P4H-1, P4H1, P4ha1, P4ha2, P4Halpha(I), P4Halpha(II), P4Halpha(III), P4Halpha1, PBCV-1 P4H, peptidyl proline hydroxylase, PH, PHD, PHD-1, PHD1, PHD2, PHD3, procollagen prolyl 4-hydroxylase, procollagen-proline dioxygenase, proline 4-hydroxylase, proline hydroxylase, proline protocollagen hydroxylase, proline, 2-oxoglutarate dioxygenase, proline,2-oxoglutarate 4-dioxygenase, prolyl 4-hydroxylase, prolyl 4-hydroxylase A085R, prolyl hydroxylase, prolyl hydroxylase domain 1, prolyl hydroxylase domain containing protein, prolyl hydroxylase domain enzyme, prolyl hydroxylase domain protein 2, prolyl hydroxylase-1, prolyl hydroxylase-3, prolyl-4-hydroxylase, prolyl-4-hydroxylase alpha I, prolyl-4-hydroxylase alpha II, prolyl-4-hydroxylase alpha subunit 2, prolyl-4-hydroxylase alpha1, prolyl-4-hydroxylase-alpha1, prolyl-4-hydroxylases, prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating, prolyl4-hydroxylase, prolylprotocollagen dioxygenase, prolylprotocollagen hydroxylase, protocollagen hydroxylase, protocollagen proline 4-hydroxylase, protocollagen proline dioxygenase, protocollagen proline hydroxylase, protocollagen prolyl hydroxylase, PSB-II, Skp1 prolyl hydroxylase, type I C-P4H, type I proly 4-hydroxylase, type I proyl 4-hydroxylase, type II proyl 4-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.2 procollagen-proline 4-dioxygenase

KM Value

KM Value on EC 1.14.11.2 - procollagen-proline 4-dioxygenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.02
(Ala-Thr-Pro-Pro-Pro-Val)3
-
1.26
(ATPPPV)3
-
sequence present in arabinogalactan protein
0.95
(L-Pro-L-Ala-L-Pro-L-Lys)2
-
recombinant enzyme
-
0.09 - 0.31
(L-Pro-L-Ala-L-Pro-L-Lys)3
-
0.25
(L-Pro-L-Glu-L-Pro-L-Pro-L-Ala)5 L-proline
-
complex of recombinant subunits PHY-4.1 and PDI2
0.01 - 2.9
(L-Pro-L-Pro-Gly)10
-
2.5
(L-Pro-L-Pro-Gly)10 L-proline
-
complex of recombinant subunits PHY-4.1 and PDI2
2.6
(L-Pro-L-Pro-Gly)2
-
-
-
0.1 - 1.8
(L-Pro-L-Pro-Gly)5
-
0.12
(L-Ser-L-Pro)19 L-proline
-
-
0.1
(L-Ser-L-Pro-L-Ala-L-Pro-L-Pro)5 L-proline
-
-
0.1
(L-Ser-L-Pro-L-Glu-L-Pro-L-Pro)5 L-proline
-
-
0.1
(L-Ser-L-Pro-L-Lys-L-Pro-L-Pro)5 L-proline
-
-
0.002 - 0.02
(Pro-Ala-Pro-Lys)10
0.09
(Pro-Ala-Pro-Lys)3
-
0.05
(Pro-Ala-Pro-Lys)5
-
recombinant enzyme
0.004 - 1
(Pro-Glu-Pro-Pro-Ala)5
0.01 - 1.27
(Pro-Pro-Gly)10
1.5
(Pro-Pro-Gly)10 L-proline
-
-
0.14 - 0.78
(Ser-Pro)5
0.02
(Ser-Pro-Lys-Pro-Pro)5
0.006
100-amino acid alpha1(I) collagen fragment
-
PHY-1/PHY-2/(PDI-2)2 P4H tetramer
-
0.001 - 1
2-oxoglutarate
0.0002
510-amino acid alpha1(I) collagen fragment
-
PHY-1/PHY-2/(PDI-2)2 P4H tetramer
-
0.14 - 0.37
ascorbate
0.1 - 0.5
carboxymethylated collagen L-proline
-
0.001 - 0.0042
DALTLLAPAAGDTIISLDYG
0.13 - 0.38
DALTLLAPAAGDTIISLFG
0.078
dansyl-Gly-Phe-Pro-Gly-OEt
-
-
0.001 - 0.0042
DLDLEALAPYIPADDDFQL
0.01 - 0.02
DLDLEMLAPAIPMDDDFQL
0.05
DLDLEMLAPAIPMDDDFQLRSFDQ
-
0.02
DLDLEMLAPGIPMDDDFQL
C-terminal hydroxylation site of HIF-1alpha
0.03 - 0.1
DLDLEMLAPYIPMD
0.009 - 0.1
DLDLEMLAPYIPMDD
0.007 - 0.07
DLDLEMLAPYIPMDDDF
0.007 - 0.008
DLDLEMLAPYIPMDDDFQL
0.006 - 0.008
DLDLEMLAPYIPMDDDFQLRSFDQ
0.007 - 0.014
DLEMLAPYIPMDDDFQL
0.007 - 0.08
EMLAPYIPMDDDFQL
0.0004 - 0.016
Fe2+
7.8 - 22
Gly-Val-Pro-Gly-Val
0.00002
His10-rSkp1A
-
-
4.8
L-Pro-L-Ala-L-Pro-L-Lys
-
recombinant enzyme
-
20
L-Pro-L-Pro-Gly
-
0.445
L-proline
-
-
0.015
LAPYIPMDDDFQL
-
8.6
Lys-Pro-Ala
-
recombinant enzyme
0.0000025
lysine hydroxylated protocollagen
-
-
-
0.03 - 1.5
O2
0.5 - 1.2
PEG-Gly-Tyr-4-fluoroproline-GlyOEt
0.03
peptidyl L-proline
-
-
-
0.03 - 0.13
poly L-proline
-
6.4
poly(ethylene glycol)-Gly-L-Tyr-(2S)-4-thiaproline-Gly-OCH2CH2OH
-
30°C, pH 7.8
1.6
poly(ethylene glycol)-Gly-L-Tyr-L-(2S,4S)-4-fluoroproline-Gly-OCH2CH2OH
-
30°C, pH 7.8
0.58
poly(ethylene glycol)-Gly-L-Tyr-L-Pro-Gly-OCH2CH2OH
-
30°C, pH 7.8
0.002 - 0.65
poly(L-Pro)
0.0002 - 1.59
poly(L-proline)
-
0.0000016
Procollagen L-proline
-
-
0.00000001 - 0.005
Protocollagen
-
0.0002
protocollagen type I L-proline
-
0.01
Ser-Pro-Pro-Pro-Pro-Val-Ser-Pro-Pro-Pro-Val-Ser-Pro-Pro-Pro-Pro-Val
-
0.04
Ser-Pro-Pro-Pro-Val-Tyr-Lys-Ser-Pro-Pro-Pro-Pro-Val-Lys-His-Tyr-Ser-Pro-Pro-Pro-Val
-
0.66
SPPPPVSPPPVSPPPPV
-
sequence present in extensin
0.38
SPPPPVYKSPPPPVKHYSPPPV
-
sequence present in extensin
22.2
tert-butyloxycarbonyl-Gly-Val-Pro-Gly-Val-OH
-
-
37.2
tert-butyloxycarbonyl-L-Pro-L-Pro-Gly
-
-
-
24
tert-butyloxycarbonyl-Pro-Pro-Ala-Pro-OH
-
-
32.2
tert-butyloxycarbonyl-Pro-Pro-Gln-Pro-OCH3
-
-
38.9
tert-butyloxycarbonyl-Pro-Pro-Gly-Pro-OH
-
-
37.4
tert-butyloxycarbonyl-Pro-Pro-Gly-Pro-Pro-OH
-
-
10.7
tert-butyloxycarbonyl-Val-Pro-Gly-Val-OH
-
-
additional information
additional information
-