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1.14.11.1: gamma-butyrobetaine dioxygenase

This is an abbreviated version!
For detailed information about gamma-butyrobetaine dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.1

Reaction

4-Trimethylammoniobutanoate
+
2-oxoglutarate
+
O2
=
3-hydroxy-4-trimethylammoniobutanoate
+
succinate
+
CO2

Synonyms

4-trimethylaminobutyric acid dioxygenase, alpha-butyrobetaine hydroxylase, BBD, BBH, BBOX, BBOX1, Bu hydroxylase, butyrobetaine hydroxylase, gamma butyrobetaine hydroxylase, gamma-BBD, gamma-BBH, gamma-buryrobetaine dioxygenase, gamma-butyrobetaine dioxygenase, gamma-butyrobetaine hydroxylase, gamma-butyrobetaine hydroxylase 1, GBB hydroxylase, GBBH, hBBOX, oxygenase, gamma-butyrobetaine di-, psBBOX

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.1 gamma-butyrobetaine dioxygenase

Reference

Reference on EC 1.14.11.1 - gamma-butyrobetaine dioxygenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lindstedt, G.; Lindstedt, S.
Cofactor requirements of gamma-butyrobetaine hydroxylase from rat liver
J. Biol. Chem.
245
4178-4186
1970
Rattus norvegicus
Manually annotated by BRENDA team
Lindstedt, G.; Lindstedt, S.; Nordin, I.
Purification and properties of gamma-butyrobetaine hydroxylase from Pseudomonas sp AK 1
Biochemistry
16
2181-2188
1977
Pseudomonas sp., Pseudomonas sp. AK1
Manually annotated by BRENDA team
Carter, A.L.; Stratman, F.W.
A rapid and sensitive assay of gamma-butyrobetaine hydroxylase
FEBS Lett.
111
112-114
1980
Rattus norvegicus
Manually annotated by BRENDA team
Kondo, A.; Blanchard, J.S.; Englard, S.
Purification and properties of calf liver gamma-butyrobetaine hydroxylase
Arch. Biochem. Biophys.
212
338-346
1981
Bos taurus
Manually annotated by BRENDA team
Holme, E.; Lindstedt, S.; Nordin, I.
Uncoupling in the gamma-butyrobetaine hydroxylase reaction by D- and L-carnitine
Biochem. Biophys. Res. Commun.
107
518-524
1982
Homo sapiens, Pseudomonas sp., Pseudomonas sp. AK1
Manually annotated by BRENDA team
Blanchard, J.S.; Englard, S.; Kondo, A.
gamma-Butyrobetaine hydroxylase: A unique protctive effect of catalase
Arch. Biochem. Biophys.
219
327-334
1982
Pseudomonas sp.
Manually annotated by BRENDA team
Lindstedt, S.; Nordin, I.
Multiple forms of gamma-butyrobetaine hydroxylase (EC 1.14.11.1)
Biochem. J.
223
119-127
1984
Homo sapiens
Manually annotated by BRENDA team
Punekar, N.S.; Wehbie, R.S.; Lardy, H.A.
gamma-Butyrobetaine hydroxylase and the protective role of glutathione peroxidase
J. Biol. Chem.
262
6720-6724
1987
Rattus norvegicus
Manually annotated by BRENDA team
Wehbie, R.S.; Punekar, N.S.; Lardy, H.A.
Rat liver gamma-butyrobetaine hydroxylase catalyzed reaction: influence of potassium, substrates, and substrate analogues on hydroxylation and decarboxylation
Biochemistry
27
2222-2228
1988
Rattus norvegicus
Manually annotated by BRENDA team
Ziering, D.L.; Pascal, R.A.
Mechanism-based inhibition of bacterial gamma-butyrobetaine hydroxylase
J. Am. Chem. Soc.
112
834-838
1990
Pseudomonas sp., Pseudomonas sp. AK1
-
Manually annotated by BRENDA team
Ng, S.F.; Hanauske-Abel, H.M.; Englard, S.
Cosubstrate binding site of Pseudomonas sp. AK1 gamma-butyrobetaine hydroxylase. Interactions with structural analogs of alpha-ketoglutarate
J. Biol. Chem.
266
1526-1533
1991
Pseudomonas sp., Pseudomonas sp. AK1
Manually annotated by BRENDA team
Petter, R.C.; Banerjee, S.; Englard, S.
Inhibition of gamma-butyrobetaine hydroxylase by cyclopropyl-substituted gamma-butyrobetaines
J. Org. Chem.
55
3088-3097
1990
Pseudomonas sp.
-
Manually annotated by BRENDA team
Englard, S.; Blanchard, J.S.; Midelfort, C.F.
gamma-Butyrobetaine hydroxylase: stereochemical course of the hydroxylation reaction
Biochemistry
24
1110-1116
1985
Bos taurus, Pseudomonas sp., Pseudomonas sp. AK1
Manually annotated by BRENDA team
Dunn, W.A.; Rettura, G.; Seifter, E.; Englard, S.
Carnitine biosynthesis from gamma-butyrobetaine and from exogenous protein-bound 6-N-trimethyl-L-lysine by the perfused guinea pig liver. Effect of ascorbate deficiency on the in situ activity of gamma-butyrobetaine hydroxylase
J. Biol. Chem.
259
10764-10770
1984
Cavia porcellus
Manually annotated by BRENDA team
Lindstedt, G.
Hydroxylation of gamma-butyrobetaine to carnitine in rat liver
Biochemistry
6
1271-1282
1967
Rattus norvegicus
Manually annotated by BRENDA team
Ruetschi, U.; Nordin, I.; Odelhog, B.; Jornvall, H.; Lindstedt, S.
gamma-Butyrobetaine hydroxylase. Structural characterization of the Pseudomonas enzyme
Eur. J. Biochem.
213
1075-1080
1993
Homo sapiens, Pseudomonas sp., Pseudomonas sp. AK1
Manually annotated by BRENDA team
Paul, H.S.; Sekas, G.; Adibi, S.A.
Carnitine biosynthesis in hepatic peroxisomes. Demonstration of gamma-butyrobetaine hydroxylase activity
Eur. J. Biochem.
203
599-605
1992
Rattus norvegicus
Manually annotated by BRENDA team
Vaz, F.M.; van Gool, S.; Ofman, R.; Ijlst, L.; Wanders, R.J.
Carnitine biosynthesis. Purification of gamma-butyrobetaine hydroxylase from rat liver
Adv. Exp. Med. Biol.
466
117-124
1999
Rattus norvegicus
Manually annotated by BRENDA team
Galland, S.; Le Borgne, F.; Guyonnet, D.; Clouet, P.; Demarquoy, J.
Purification and characterization of the rat liver gamma-butyrobetaine hydroxylase
Mol. Cell. Biochem.
178
163-168
1998
Rattus norvegicus
Manually annotated by BRENDA team
Galland, S.; Georges, B.; Le Borgne, F.; Conductier, G.; Dias, J.V.; Demarquoy, J.
Thyroid hormone controls carnitine status through modifications of g-butyrobetaine hydroxylase activity and gene expression
Cell. Mol. Life Sci.
59
540-545
2002
Rattus norvegicus
Manually annotated by BRENDA team
Galland, S.; Le Borgne, F.; Bouchard, F.; Georges, B.; Clouet, P.; Grand-Jean, F.; Demarquoy, J.
Molecular cloning and characterization of the cDNA encoding the rat liver gamma-butyrobetaine hydroxylase
Biochim. Biophys. Acta
1441
85-92
1999
Rattus norvegicus
Manually annotated by BRENDA team
van Vlies, N.; Wanders, R.J.; Vaz, F.M.
Measurement of carnitine biosynthesis enzyme activities by tandem mass spectrometry: differences between the mouse and the rat
Anal. Biochem.
354
132-139
2006
Mus musculus
Manually annotated by BRENDA team
Rigault, C.; Le Borgne, F.; Demarquoy, J.
Genomic structure, alternative maturation and tissue expression of the human BBOX1 gene
Biochim. Biophys. Acta
1761
1469-1481
2006
Homo sapiens
Manually annotated by BRENDA team
Davis, A.T.; Monroe, T.J.
Carnitine deficiency and supplementation do not affect the gene expression of carnitine biosynthetic enzymes in rats
J. Nutr.
135
761-764
2005
Rattus norvegicus
Manually annotated by BRENDA team
Debreceni, B.; Farkas, V.; Fischer, G.M.; Sandor, A.
Effect of aromatic ring-containing drugs on carnitine biosynthesis in rats with special regard to p-aminomethylbenzoic acid
Metab. Clin. Exp.
54
1582-1586
2005
Rattus norvegicus
Manually annotated by BRENDA team
Buermans, H.P.; Redout, E.M.; Schiel, A.E.; Musters, R.J.; Zuidwijk, M.; Eijk, P.P.; van Hardeveld, C.; Kasanmoentalib, S.; Visser, F.C.; Ylstra, B.; Simonides, W.S.
Microarray analysis reveals pivotal divergent mRNA expression profiles early in the development of either compensated ventricular hypertrophy or heart failure
Physiol. Genomics
21
314-323
2005
Rattus norvegicus
Manually annotated by BRENDA team
van Vlies, N.; Ferdinandusse, S.; Turkenburg, M.; Wanders, R.J.; Vaz, F.M.
PPARalpha-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation
Biochim. Biophys. Acta
1767
1134-1142
2007
Mus musculus
Manually annotated by BRENDA team
Ringseis, R.; Luci, S.; Spielmann, J.; Kluge, H.; Fischer, M.; Geissler, S.; Wen, G.; Hirche, F.; Eder, K.
Clofibrate treatment up-regulates novel organic cation transporter (OCTN)-2 in tissues of pigs as a model of non-proliferating species
Eur. J. Pharmacol.
583
11-17
2008
Sus scrofa
Manually annotated by BRENDA team
Fujita, M.; Nakanishi, T.; Shibue, Y.; Kobayashi, D.; Moseley, R.H.; Shirasaka, Y.; Tamai, I.
Hepatic uptake of gamma-butyrobetaine, a precursor of carnitine biosynthesis, in rats
Am. J. Physiol. Gastrointest. Liver Physiol.
297
G681-G686
2009
Rattus norvegicus
Manually annotated by BRENDA team
Fischer, M.; Keller, J.; Hirche, F.; Kluge, H.; Ringseis, R.; Eder, K.
Activities of gamma-butyrobetaine dioxygenase and concentrations of carnitine in tissues of pigs
Comp. Biochem. Physiol. A
153
324-331
2009
Sus scrofa
Manually annotated by BRENDA team
Hirche, F.; Fischer, M.; Keller, J.; Eder, K.
Determination of carnitine, its short chain acyl esters and metabolic precursors trimethyllysine and gamma-butyrobetaine by quasi-solid phase extraction and MS/MS detection
J. Chromatogr. B
877
2158-2162
2009
Sus scrofa
Manually annotated by BRENDA team
Garcia-Delgado, M.; Peral, M.J.; Duran, J.M.; Garcia-Miranda, P.; Calonge, M.L.; Ilundain, A.A.
Ontogeny of Na(+)/L-carnitine transporter and of gamma-trimethylaminobutyraldehyde dehydrogenase and gamma-butyrobetaine hydroxylase genes expression in rat kidney
Mech. Ageing Dev.
130
227-233
2009
Rattus norvegicus (Q9QZU7)
Manually annotated by BRENDA team
Tars, K.; Rumnieks, J.; Zeltins, A.; Kazaks, A.; Kotelovica, S.; Leonciks, A.; Sharipo, J.; Viksna, A.; Kuka, J.; Liepinsh, E.; Dambrova, M.
Crystal structure of human gamma-butyrobetaine hydroxylase
Biochem. Biophys. Res. Commun.
398
634-639
2010
Homo sapiens (O75936), Homo sapiens
Manually annotated by BRENDA team
Rydzik, A.M.; Leung, I.K.; Kochan, G.T.; Thalhammer, A.; Oppermann, U.; Claridge, T.D.; Schofield, C.J.
Development and application of a fluoride-detection-based fluorescence assay for gamma-butyrobetaine hydroxylase
ChemBioChem
13
1559-1563
2012
Homo sapiens
Manually annotated by BRENDA team
Rydzik, A.M.; Brem, J.; Struwe, W.B.; Kochan, G.T.; Benesch, J.L.; Schofield, C.J.
Ejection of structural zinc leads to inhibition of gamma-butyrobetaine hydroxylase
Bioorg. Med. Chem. Lett.
24
4954-4957
2014
Homo sapiens (O75936)
Manually annotated by BRENDA team
Rydzik, A.M.; Chowdhury, R.; Kochan, G.T.; Williams, S.T.; McDonough, M.A.; Kawamura, A.; Schofield, C.J.
Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of gamma-butyrobetaine hydroxylase
Chem. Sci.
5
1765-1771
2014
Homo sapiens (O75936)
Manually annotated by BRENDA team
Kamps, J.J.; Khan, A.; Choi, H.; Lesniak, R.K.; Brem, J.; Rydzik, A.M.; McDonough, M.A.; Schofield, C.J.; Claridge, T.D.; Mecinovic, J.
Cation-Pi interactions contribute to substrate recognition in gamma-butyrobetaine hydroxylase catalysis
Chemistry
22
1270-1276
2016
Pseudomonas sp. (P80193), Pseudomonas sp. AK-1 (P80193)
Manually annotated by BRENDA team
Tars, K.; Leitans, J.; Kazaks, A.; Zelencova, D.; Liepinsh, E.; Kuka, J.; Makrecka, M.; Lola, D.; Andrianovs, V.; Gustina, D.; Grinberga, S.; Liepinsh, E.; Kalvinsh, I.; Dambrova, M.; Loza, E.; Pugovics, O.
Targeting carnitine biosynthesis discovery of new inhibitors against gamma-butyrobetaine hydroxylase
J. Med. Chem.
57
2213-2236
2014
Homo sapiens (O75936)
Manually annotated by BRENDA team
Khan, A.; Lesniak, R.; Brem, J.; Rydzik, A.; Choi, H.; Leung, I.; McDonough, M.; Schofield, C.; Claridge, T.
Development and application of ligand-based NMR screening assays for gamma-butyrobetaine hydroxylase
MedChemComm
7
873-880
2016
Homo sapiens (O75936)
-
Manually annotated by BRENDA team
Rydzik, A.M.; Leung, I.K.; Kochan, G.T.; Loik, N.D.; Henry, L.; McDonough, M.A.; Claridge, T.D.; Schofield, C.J.
Comparison of the substrate selectivity and biochemical properties of human and bacterial gamma-butyrobetaine hydroxylase
Org. Biomol. Chem.
12
6354-6358
2014
Homo sapiens (O75936), Pseudomonas sp. (P80193), Pseudomonas sp. AK-1 (P80193)
Manually annotated by BRENDA team
Lin, X.; Lyvers Peffer, P.A.; Woodworth, J.; Odle, J.
Ontogeny of carnitine biosynthesis in Sus scrofa domesticus, inferred from gamma-butyrobetaine hydroxylase (dioxygenase) activity and substrate inhibition
Am. J. Physiol. Regul. Integr. Comp. Physiol.
319
R43-R49
2020
Sus scrofa (F1SGL4)
Manually annotated by BRENDA team
Lesniak, R.K.; Rydzik, A.M.; Kamps, J.J.A.G.; Kahn, A.; Claridge, T.D.W.; Schofield, C.J.
19F NMR studies on gamma-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode
Chem. Commun. (Camb.)
55
14717-14720
2019
Homo sapiens (O75936)
Manually annotated by BRENDA team
Liao, C.; Zhang, Q.
BBOX1 promotes triple-negative breast cancer progression by controlling IP3R3 stability
Mol. Cell. Oncol.
7
1813526
2020
Homo sapiens (O75936)
Manually annotated by BRENDA team