1.14.11.1: gamma-butyrobetaine dioxygenase
This is an abbreviated version!
For detailed information about gamma-butyrobetaine dioxygenase, go to the full flat file.
Word Map on EC 1.14.11.1
-
1.14.11.1
-
cardioprotective
-
carnitine-dependent
-
3-2,2,2-trimethylhydrazinium
-
mildronate
-
trimethyllysine
-
mid1
-
alpha4
-
medicine
-
d-carnitine
-
dihydrate
-
drug development
-
molecular biology
- 1.14.11.1
-
cardioprotective
-
carnitine-dependent
-
3-2,2,2-trimethylhydrazinium
- mildronate
- trimethyllysine
- mid1
-
alpha4
- medicine
- d-carnitine
- dihydrate
- drug development
- molecular biology
Reaction
Synonyms
4-trimethylaminobutyric acid dioxygenase, alpha-butyrobetaine hydroxylase, BBD, BBH, BBOX, BBOX1, Bu hydroxylase, butyrobetaine hydroxylase, gamma butyrobetaine hydroxylase, gamma-BBD, gamma-BBH, gamma-buryrobetaine dioxygenase, gamma-butyrobetaine dioxygenase, gamma-butyrobetaine hydroxylase, gamma-butyrobetaine hydroxylase 1, GBB hydroxylase, GBBH, hBBOX, oxygenase, gamma-butyrobetaine di-, psBBOX
ECTree
Advanced search results
Application
Application on EC 1.14.11.1 - gamma-butyrobetaine dioxygenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
drug development
enzyme BBOX is a drug target for the treatment of myocardial infarction
medicine
molecular biology
-
a fluorescence assay based on the detection of fluoride released from reactions of fluorinated substrates with BBOX by the use of tert-butyldimethylsilyl-protected fluorescein is developed. (3S)-3-fluoro-4-(trimethylammonio)butanoate is a good substrate for BBOX, releasing fluoride when subjected to the enzyme
-
effects of hyperthyroidism and hypothyroidism on enzyme activity
medicine
-
activity of gamma-butyrobetaine dioxygenase in the liver is lower in pigs treated with clofibrate than in control pigs. Concentrations of gamma-butyrobetaine does not differ between both groups. Pigs treated with clofibrate have higher relative mRNA concentrations of organic cation transporter OCTN2 in liver, skeletal muscle and epithelial cells from small intestine than control pigs. Pigs treated with clofibrate have also higher concentrations of free and total carnitine in the liver and a higher concentration of free carnitine in skeletal muscle than control pigs
medicine
-
both enhancement of carnitine biosynthesis due to increased ?-butyrobetaine dioxygenase activity, extra-hepatic gamma-butyrobetaine synthesis and increased hepatic carnitine import contributes to the increased hepatic carnitine levels after fasting
medicine
BBOX is a therapeutic target in humans, the BBOX inhibitor mildronate is used to decrease fatty acid oxidation in patients after myocardial infarction
medicine
inhibition of BBOX is reported to aid in recovery after acute stroke