1.13.11.74: 2-aminophenol 1,6-dioxygenase

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For detailed information about 2-aminophenol 1,6-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.74

1.13.11.74

2-aminomuconic

dioxygenases

nitrobenzene

fission

extradiol

6-semialdehyde

alpha-subunits

protocatechuate

beta-subunits

comamonas

meta-cleavage

dioxygenation

suicide

catecholic

pseudoalcaligenes

4-nitrocatechol

homoprotocatechuate

mutase

wastewater

4-oxalocrotonate

2-his-1-carboxylate

facial

nonhaem

nitroreductase

alpha2beta2

Reaction

Synonyms

2-aminophenol-1,6-dioxygenase, amnA, amnB, amnBA, APD

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.74 2-aminophenol 1,6-dioxygenase

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Results	in table
48	AA Sequence
6	Cloned(Commentary)
2	Crystallization (Commentary)
1	General Stability
1	IC50 Value
74	Inhibitors
9	Ki Value [mM]
7	KM Value [mM]
3	Metals/Ions
14	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
45	Organism
4	Pathway
2	pH Optimum
1	pH Range
10	Protein Variants
6	Purification (Commentary)
1	Reaction
18	Reference
2	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
47	Substrates and Products (Substrate)
14	Subunits
20	Synonyms
1	Systematic Name
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.13.11.74 - 2-aminophenol 1,6-dioxygenase

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2-aminophenol:oxygen 1,6-oxidoreductase (decyclizing)

The enzyme, a member of the nonheme-iron(II)-dependent dioxygenase family, is an extradiol-type dioxygenase that utilizes a non-heme ferrous iron to cleave the aromatic ring at the meta position (relative to the hydroxyl substituent). The enzyme also has some activity with 2-amino-5-methylphenol and 2-amino-4-methylphenol [1]. The enzyme from the bacterium Comamonas testosteroni CNB-1 also has the activity of EC 1.13.11.76, 2-amino-5-chlorophenol 1,6-dioxygenase [2].