1.13.11.66: hydroquinone 1,2-dioxygenase

This is an abbreviated version!
For detailed information about hydroquinone 1,2-dioxygenase, go to the full flat file.

Reaction

Synonyms

HQDO, hydroquinone 1,2-dioxygenase, hydroquinone dioxygenase, LinE, mnpC, PcpA, PdcDE, PnpC1, PnpC2, PnpCD, ring-cleavage hydroquinone 1,2-dioxygenase, two-subunit hydroquinone 1,2-dioxygenase, type II HQDO, YaiA

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.66 hydroquinone 1,2-dioxygenase

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Results	in table
1	Activating Compound
35	AA Sequence
7	Cloned(Commentary)
3	Crystallization (Commentary)
2	Expression
7	General Information
1	General Stability
27	Inhibitors
10	kcat/KM [mM/s]
1	Ki Value [mM]
17	KM Value [mM]
15	Metals/Ions
12	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
66	Organism
5	Pathway
7	pH Optimum
4	pH Range
2	pH Stability
19	Protein Variants
6	Purification (Commentary)
3	Reaction
25	Reference
5	Specific Activity [micromol/min/mg]
3	Storage Stability
75	Substrates and Products (Substrate)
20	Subunits
27	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
12	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.13.11.66 - hydroquinone 1,2-dioxygenase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2,2'-dipyridyl

Pseudomonas fluorescens

-

inactivation

719714

2,6-dibromophenol

Sphingobium chlorophenolicum

Q9ZBB0

competitive

718916

3,4-dihydroxybenzoate

Sphingomonas sp.

F8TW82, F8TW83

0.2 mM, 94% inhibition; 0.2 mM, 94% inhibition

718555

3-bromocatechol

Sphingobium chlorophenolicum

Q9ZBB0

inactivation

718916

4-coumaric acid

Sphingomonas sp.

F8TW82, F8TW83

0.2 mM, 97% inhibition; 0.2 mM, 97% inhibition

718555

4-hydroxybenzoate

3 entries

4-Hydroxybenzonitrile

Pseudomonas fluorescens

-

0.2 mM, no residual activity

719714

4-hydroxycinnamate

Pseudomonas fluorescens

-

0.2 mM, no residual activity

719714

4-nitrophenol

2 entries

bromohydroquinone

Pseudomonas fluorescens

-

substrate inhibition

719714

caffeic acid

Sphingomonas sp.

F8TW82, F8TW83

0.2 mM, 98% inhibition; 0.2 mM, 98% inhibition

718555

catechol

Sphingomonas sp.

F8TW82, F8TW83

0.2 mM, 93% inhibition; 0.2 mM, 93% inhibition

718555

chlorohydroquinone

Pseudomonas fluorescens

-

substrate inhibition

719714

hydrogen peroxide

Pseudomonas fluorescens

-

inactivation

719714

Hydroxyhydroquinone

Pseudomonas fluorescens

-

0.2 mM, 9% residual activity

719714

methoxyhydroquinone

Pseudomonas fluorescens

-

strong substrtae inhibition

719714

o-phenanthroline

Pseudomonas fluorescens

-

inactivation

719714

ortho-disubstituted phenols

Sphingobium chlorophenolicum

Q9ZBB0

-

718916

-

phenol

Sphingomonas sp.

F8TW82, F8TW83

0.2 mM, 98% inhibition; 0.2 mM, 98% inhibition

718555

resorcinol

Sphingomonas sp.

F8TW82, F8TW83

0.2 mM, 99% inhibition; 0.2 mM, 99% inhibition

718555

vanillate

Sphingomonas sp.

F8TW82, F8TW83

0.2 mM, 86% inhibition; 0.2 mM, 86% inhibition

718555

Vanillyl alcohol

Sphingomonas sp.

F8TW82, F8TW83

0.2 mM, 62% inhibition; 0.2 mM, 62% inhibition

718555

additional information

2 entries

-

4-hydroxybenzoate

Pseudomonas fluorescens

-

competitive with hydroquinone

719714

4-hydroxybenzoate

Sphingomonas sp.

F8TW82, F8TW83

0.2 mM, 46% inhibition; 0.2 mM, 46% inhibition

718555

4-hydroxybenzoate

Sphingomonas sp.

F8TW82; F8TW83

binding structure, overview

744430

4-nitrophenol

Pseudomonas fluorescens

-

0.2 mM, no residual activity

719714

4-nitrophenol

Sphingomonas sp.

F8TW82; F8TW83

binding structure, overview

744430

additional information

Lactococcus lactis

-

4-hydrobenzoate, the competitive inhibitor of the heterotetrameric HapCD hydroquinone dioxygenase of Pseudomonas fluorescens ACB, stabilizes the enzyme

745802

-

additional information

Pseudomonas fluorescens

-

weak or no inhibition: 2-hydroxy-, 3-hydroxy-, 2,3-dihydroxy-, 2,5-dihydroxy-, 2,6-dihydroxy-, 3,4-dihydroxy-, 3,4,5-trihydroxy-, 3-chloro-4-hydroxy-, tetrafluoro-4-hydroxy-, 3-amino-4-hydroxy-, 4-hydroxy-3-methoxy-, 4-amino- and methyl 4-hydroxybenzoate; 6-hydroxynicotinate, 4-hydroxypropiophenone, 4-hydroxymandelate, 4-hydroxyphenylglycine, 4-hydroxybenzenesulfonic acid, and 4-methyl-, 4-methoxy-, and 4-aminophenol

719714

-