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1.13.11.4: gentisate 1,2-dioxygenase

This is an abbreviated version!
For detailed information about gentisate 1,2-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.4

Reaction

2,5-Dihydroxybenzoate
+
O2
=
maleylpyruvate

Synonyms

2,5-dihydroxybenzoate dioxygenase, DsmD, EC 1.13.1.4, EC 1.99.2.4, eGDO, GDO, GDO-II, gdoA, GDOsp, GenH, gentisate dioxygenase, gentisate oxygenase, gentisate-1,2-dioxygenase, gentisic acid oxidase, gtdA-2, hbzE, Nagl1, Nagl2, Nagl3, NarI, oxygenase, gentisate 1,2-di-, P25X gentisate 1,2-dioxygenase, P35X gentisate 1,2-dioxygenase, salicylate 1,2-dioxygenase, SDO

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.4 gentisate 1,2-dioxygenase

Substrates Products

Substrates Products on EC 1.13.11.4 - gentisate 1,2-dioxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1,4-dihydroxy-2-naphthoate + O2
?
show the reaction diagram
1-hydroxy-2-naphthoate + O2
?
show the reaction diagram
2,5-dihydroxybenzoate + O2
maleylpyruvate
show the reaction diagram
2,5-xylenol + O2
?
show the reaction diagram
3,4-dichlorosalicylate + O2
?
show the reaction diagram
3,4-dimethylgentisate + O2
?
show the reaction diagram
3,5-dibromosalicylate + O2
?
show the reaction diagram
3,6-dichlorogentisate + O2
?
show the reaction diagram
3-aminosalicylate + O2
(2E,4Z)-2-amino-6-oxohepta-2,4-dienoate
show the reaction diagram
-
-
-
?
3-aminosalicylate + O2
?
show the reaction diagram
3-bromogentisate + O2
3-bromo-4-hydroxy-6-oxo-hepta-2,4-dienedioic acid
show the reaction diagram
3-bromosalicylate + O2
(2E,4Z)-2-bromo-6-oxohepta-2,4-dienoate
show the reaction diagram
low activity
-
-
?
3-bromosalicylate + O2
?
show the reaction diagram
-
kcat/KM is less than 1% of the kcat/Km for gentisate
-
-
?
3-chlorogentisate + O2
3-chloro-4-hydroxy-6-oxo-hepta-2,4-dienedioic acid
show the reaction diagram
3-chlorosalicylate + O2
(2E,4Z)-2-chloro-6-oxohepta-2,4-dienoate
show the reaction diagram
low activity
-
-
?
3-chlorosalicylate + O2
?
show the reaction diagram
-
kcat/KM is less than 1% of the kcat/Km for gentisate
-
-
?
3-ethylgentisate + O2
3-ethyl-4-hydroxy-6-oxo-hepta-2,4-dienedioic acid
show the reaction diagram
3-fluorogentisate + O2
3-fluoro-4-hydroxy-6-oxo-hepta-2,4-dienedioic acid
show the reaction diagram
3-hydroxybenzoate + O2
3,4-dihydroxy-6-oxo-hepta-2,4-dienedioic acid
show the reaction diagram
3-hydroxybenzoate + O2
?
show the reaction diagram
3-hydroxysalicylate + O2
(2E,4Z)-2-hydroxy-6-oxohepta-2,4-dienoate
show the reaction diagram
low activity
-
-
?
3-hydroxysalicylate + O2
?
show the reaction diagram
-
kcat/KM is less than 1% of the kcat/Km for gentisate
-
-
?
3-isopropyl-gentisate + O2
4-hydroxy-3-isopropyl-6-oxo-hepta-2,4-dienedioic acid
show the reaction diagram
3-isopropylgentisate + O2
4-hydroxy-3-isopropyl-6-oxo-hepta-2,4-dienedioic acid
show the reaction diagram
3-methylgentisate + O2
3-methyl-4-hydroxy-6-oxo-hepta-2,4-dienedioic acid
show the reaction diagram
-
Vmax is 10.1% of Vmax for gentisate
-
-
?
3-methylgentisate + O2
4-hydroxy-3-methyl-6-oxo-hepta-2,4-dienedioic acid
show the reaction diagram
3-methylsalicylate + O2
(2Z,4Z)-2-methyl-6-oxohepta-2,4-dienoate
show the reaction diagram
low activity
-
-
?
3-methylsalicylate + O2
?
show the reaction diagram
-
kcat/KM is less than 1% of the kcat/Km for gentisate
-
-
?
3-O-methylgentisate + O2
?
show the reaction diagram
4-aminosalicylate + O2
(2Z,4E)-3-amino-6-oxohepta-2,4-dienoate
show the reaction diagram
-
-
-
?
4-bromosalicylate + O2
?
show the reaction diagram
-
kcat/KM is less than 1% of the kcat/Km for gentisate
-
-
?
4-chlorogentisate + O2
2-chloro-4-hydroxy-6-oxo-hepta-2,4-dienedioic acid
show the reaction diagram
4-chlorosalicylate + O2
(2Z,4E)-3-chloro-6-oxohepta-2,4-dienoate
show the reaction diagram
low activity
-
-
?
4-chlorosalicylate + O2
?
show the reaction diagram
-
kcat/KM is less than 1% of the kcat/Km for gentisate
-
-
?
4-fluorogentisate + O2
2-fluoro-4-hydroxy-6-oxo-hepta-2,4-dienedioic acid
show the reaction diagram
4-hydroxybenzoate + O2
?
show the reaction diagram
4-hydroxysalicylate + O2
(2Z,4E)-3-hydroxy-6-oxohepta-2,4-dienoate
show the reaction diagram
low activity
-
-
?
4-hydroxysalicylate + O2
?
show the reaction diagram
-
kcat/KM is less than 1% of the kcat/Km for gentisate
-
-
?
4-isopropylgentisate + O2
4-hydroxy-2-isopropyl-6-oxo-hepta-2,4-dienedioic acid
show the reaction diagram
4-methylgentisate + O2
4-hydroxy-2-methyl-6-oxo-hepta-2,4-dienedioic acid
show the reaction diagram
4-methylsalicylate + O2
(2Z,4Z)-3-methyl-6-oxohepta-2,4-dienoate
show the reaction diagram
low activity
-
-
?
4-methylsalicylate + O2
?
show the reaction diagram
-
kcat/KM is less than 1% of the kcat/Km for gentisate
-
-
?
4-O-methylgentisate + O2
?
show the reaction diagram
5-aminosalicylate + O2
(2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate
show the reaction diagram
5-aminosalicylate + O2
?
show the reaction diagram
5-bromosalicylate + O2
?
show the reaction diagram
-
kcat/KM is less than 1% of the kcat/Km for gentisate
-
-
?
5-chlorosalicylate + O2
(2Z,4E)-4-chloro-6-oxohepta-2,4-dienoate
show the reaction diagram
low activity
-
-
?
5-chlorosalicylate + O2
?
show the reaction diagram
-
kcat/KM is less than 1% of the kcat/Km for gentisate
-
-
?
5-fluorosalicylate + O2
(2Z,4E)-4-fluoro-6-oxohepta-2,4-dienoate
show the reaction diagram
low activity
-
-
?
5-fluorosalicylate + O2
?
show the reaction diagram
5-methylsalicylate + O2
(2Z,4Z)-4-methyl-6-oxohepta-2,4-dienoate
show the reaction diagram
low activity
-
-
?
5-methylsalicylate + O2
?
show the reaction diagram
benzoate + O2
3-hydroxy-6-oxoheptadienoic acid
show the reaction diagram
-
-
-
-
?
cinnamate + O2
?
show the reaction diagram
-
-
-
-
?
gentisate + O2
?
show the reaction diagram
gentisate + O2
maleylpyruvate
show the reaction diagram
lactate + O2
?
show the reaction diagram
phenylpropionate + O2
?
show the reaction diagram
-
-
-
-
?
salicylate + O2
2-oxohepta-3,5-dienedioic acid
show the reaction diagram
salicylate + O2
?
show the reaction diagram
-
-
-
-
?
additional information
?
-