1.13.11.4: gentisate 1,2-dioxygenase
This is an abbreviated version!
For detailed information about gentisate 1,2-dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.4
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1.13.11.4
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maleylpyruvate
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protocatechuate
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3-hydroxybenzoate
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pseudaminobacter
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salicylatoxidans
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1-hydroxy-2-naphthoate
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3,4-dioxygenase
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monohydroxylated
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fumarylpyruvate
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isofunctional
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5-hydroxylase
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ring-fission
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ring-cleaving
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extradiol
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bicupins
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nocardioides
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acidovorans
- 1.13.11.4
- maleylpyruvate
- protocatechuate
- 3-hydroxybenzoate
-
pseudaminobacter
- salicylatoxidans
- 1-hydroxy-2-naphthoate
-
3,4-dioxygenase
-
monohydroxylated
- fumarylpyruvate
-
isofunctional
-
5-hydroxylase
-
ring-fission
-
ring-cleaving
-
extradiol
-
bicupins
- nocardioides
- acidovorans
Reaction
Synonyms
2,5-dihydroxybenzoate dioxygenase, DsmD, EC 1.13.1.4, EC 1.99.2.4, eGDO, GDO, GDO-II, gdoA, GDOsp, GenH, gentisate dioxygenase, gentisate oxygenase, gentisate-1,2-dioxygenase, gentisic acid oxidase, gtdA-2, hbzE, Nagl1, Nagl2, Nagl3, NarI, oxygenase, gentisate 1,2-di-, P25X gentisate 1,2-dioxygenase, P35X gentisate 1,2-dioxygenase, salicylate 1,2-dioxygenase, SDO
ECTree
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Metals Ions
Metals Ions on EC 1.13.11.4 - gentisate 1,2-dioxygenase
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Fe2+
Iron
additional information
contains 1 mol iron per subunit, in the presence of 2 mM Fe2+ activity is increased by 115%
Fe2+
-
purified GDO proteins NagI2 and NagI3 are highly unstable in phosphate buffer without ferrous ions
Fe2+
-
the catalytic center contains a mononuclear iron(II) ion coordinated to three histidine residues (His119, His121, and His160), located within the N-terminal domain in a solvent-accessible pocket
Fe2+
two ferrous centers are located in its two homologous cupin domains, respectively. The N-terminal Fe2+-binding site is essential for the enzyme activity but dispensable for the protein overall tertiary structure
Iron
ferrous ion specifically functions in the formation of the active tetramer structure, the enzyme contains 0.98 mol iron per mol subunit
additional information
Ca2+, Ni2+, Mg2+, and Zn2+ have no impact on enzyme activity