1.13.11.4: gentisate 1,2-dioxygenase
This is an abbreviated version!
For detailed information about gentisate 1,2-dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.4
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1.13.11.4
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maleylpyruvate
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protocatechuate
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3-hydroxybenzoate
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pseudaminobacter
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salicylatoxidans
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1-hydroxy-2-naphthoate
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3,4-dioxygenase
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monohydroxylated
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fumarylpyruvate
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isofunctional
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5-hydroxylase
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ring-fission
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ring-cleaving
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extradiol
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bicupins
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nocardioides
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acidovorans
- 1.13.11.4
- maleylpyruvate
- protocatechuate
- 3-hydroxybenzoate
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pseudaminobacter
- salicylatoxidans
- 1-hydroxy-2-naphthoate
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3,4-dioxygenase
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monohydroxylated
- fumarylpyruvate
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isofunctional
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5-hydroxylase
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ring-fission
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ring-cleaving
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extradiol
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bicupins
- nocardioides
- acidovorans
Reaction
Synonyms
2,5-dihydroxybenzoate dioxygenase, DsmD, EC 1.13.1.4, EC 1.99.2.4, eGDO, GDO, GDO-II, gdoA, GDOsp, GenH, gentisate dioxygenase, gentisate oxygenase, gentisate-1,2-dioxygenase, gentisic acid oxidase, gtdA-2, hbzE, Nagl1, Nagl2, Nagl3, NarI, oxygenase, gentisate 1,2-di-, P25X gentisate 1,2-dioxygenase, P35X gentisate 1,2-dioxygenase, salicylate 1,2-dioxygenase, SDO
ECTree
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General Information
General Information on EC 1.13.11.4 - gentisate 1,2-dioxygenase
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malfunction
metabolism
physiological function
additional information
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disruption of dsmD results in a significant decline in the degradation rates of 3-chlorogentisate and the herbicide dicamba but has no effect on the degradation of gentisate. The disruption of both dsmD and gtdA leads to the inability to degrade 3-chlorogentisate and gentisate
malfunction
Rhizorhabdus dicambivorans Ndbn-20
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disruption of dsmD results in a significant decline in the degradation rates of 3-chlorogentisate and the herbicide dicamba but has no effect on the degradation of gentisate. The disruption of both dsmD and gtdA leads to the inability to degrade 3-chlorogentisate and gentisate
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narI is involved in salicylate, i.e. 3-hydroxybenzoate, and gentisate catabolism, organization of the 3HBA-gentisate catabolic cluster, overview
metabolism
the gene genH belongs to the group involved in naphthalene and salicylate degradation, by the nar and gen gene clusters, respectively, overview
metabolism
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strain CJ2 metabolizes naphthalene via the gentisate pathway using gentisate 1,2-dioxygenase, patterns in regulation, transcription and enzyme activity, overview. The nagR regulator controls the third catabolic gene cluster
metabolism
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the gene genH belongs to the group involved in naphthalene and salicylate degradation, by the nar and gen gene clusters, respectively, overview
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metabolism
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narI is involved in salicylate, i.e. 3-hydroxybenzoate, and gentisate catabolism, organization of the 3HBA-gentisate catabolic cluster, overview
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although all three nagI genes in strain CJ2 influence naphthalene degradation, the nagI3 gene plays the most significant role. NagI3 may prevent toxic intracellular levels of gentisate from accumulating in CJ2 cells
physiological function
the enzyme is involved in the 3-phenylpropionic acid degradation pathway
physiological function
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DsmD is specifically responsible for cleavage of 3-chlorogentisate, a key intermediate in the catabolism of the herbicide dicamba in Rhizorhabdus dicambivorans Ndbn-20
physiological function
Rhizorhabdus dicambivorans Ndbn-20
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DsmD is specifically responsible for cleavage of 3-chlorogentisate, a key intermediate in the catabolism of the herbicide dicamba in Rhizorhabdus dicambivorans Ndbn-20
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strain NCIMB 12038 utilizes naphthalene as a sole source of carbon and energy, and degrades naphthalene via salicylate and gentisate. The strain can also use salicylate, i.e. 3-hydroxybenzoate, as sole source of energy and carbon
additional information
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strain NCIMB 12038 utilizes naphthalene as a sole source of carbon and energy, and degrades naphthalene via salicylate and gentisate. The strain can also use salicylate, i.e. 3-hydroxybenzoate, as sole source of energy and carbon
additional information
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binding modes for salicylate and gentisate
additional information
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strain NCIMB 12038 utilizes naphthalene as a sole source of carbon and energy, and degrades naphthalene via salicylate and gentisate. The strain can also use salicylate, i.e. 3-hydroxybenzoate, as sole source of energy and carbon
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additional information
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binding modes for salicylate and gentisate
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