1.1.99.38: 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)

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For detailed information about 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent), go to the full flat file.

Reaction

Synonyms

BtrN, DOIA dehydrogenase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.99 With unknown physiological acceptors

1.1.99.38 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)

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Results	in table
47	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
4	Cofactor
2	Crystallization (Commentary)
1	General Information
1	Inhibitors
3	KM Value [mM]
2	Metals/Ions
5	Organism
5	Pathway
1	Reaction
5	Reference
7	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name
3	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.1.99.38 - 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)

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analysis of electron paramagnetic resonance signals for free enzyme, the enzyme-S-adenosyl-L-methionine complex, and a rhombic signal presumably derived from the enzyme-S-adenosyl-L-methionine-substrate ternary complex show close interaction of both S-adenosyl-L-methione and 2-deoxy-scyllo-inosamine with the [4Fe-4S] cluster

Niallia circulans

Q8G907

685280

in complex with AdoMet and substrate, to 1.56 A resolution. Structure displays a modification to the core AdoMet radical fold, instead of the canonical (beta/alpha)6 architecture, BtrN displays a (beta5/alpha4) motif. An auxiliary [4Fe-4S] cluster in BtrN, thought to bind substrate, is instead implicated in substrate-radical oxidation

Niallia circulans

Q8G907

741329