1.1.99.37: methanol dehydrogenase (nicotinoprotein)
This is an abbreviated version!
For detailed information about methanol dehydrogenase (nicotinoprotein), go to the full flat file.
Word Map on EC 1.1.99.37
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1.1.99.37
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thermotolerant
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formaldehyde
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methanolicus
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rump
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methanol-limited
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decameric
- 1.1.99.37
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thermotolerant
- formaldehyde
- methanolicus
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rump
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methanol-limited
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decameric
Reaction
Synonyms
MDH, MDO, methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase, NAD-dependent methanol dehydrogenase, NDMA-dependent methanol dehydrogenase
ECTree
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Reaction
Reaction on EC 1.1.99.37 - methanol dehydrogenase (nicotinoprotein)
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methanol + acceptor = formaldehyde + reduced acceptor
Ping-Pong type of reaction mechanism
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methanol + acceptor = formaldehyde + reduced acceptor
the low coenzyme NAD-dependent activity of MDH with C1-C4 primary alcohols is strongly stimulated by Bacillus methanolicus protein ACT, in presence of NAD(H) cofactor and Mg2+-ions. MDH activation by ACT involves hydrolytic removal of the nicotinamide mononucleotide NMN(H) moiety of the NAD(H) cofactor of MDH, changing its Ping-Pong type of reaction mechanism into a ternary complex reaction mechanism
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methanol + acceptor = formaldehyde + reduced acceptor
the low coenzyme NAD-dependent activity of MDH with C1-C4 primary alcohols is strongly stimulated by Bacillus methanolicus protein ACT, in presence of NAD(H) cofactor and Mg2+-ions. MDH activation by ACT involves hydrolytic removal of the nicotinamide mononucleotide NMN(H) moiety of the NAD(H) cofactor of MDH, changing its Ping-Pong type of reaction mechanism into a ternary complex reaction mechanism
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