1.1.99.30: 2-oxo-acid reductase

This is an abbreviated version!
For detailed information about 2-oxo-acid reductase, go to the full flat file.

Reaction

Synonyms

(2R)-hydroxycarboxlate viologen oxidoreductase, (2R)-hydroxycarboxlate-viologen-oxidoreductase, (2R)-hydroxycarboxylate-viologen-oxidoreductase, 2-oxoacid reductase, D-2-hydroxy acid dehydrogenase, dehydrogenase, D-2-hydroxy acid, HVOR, hydroxy carboxylate viologen oxidoreductase, hydroxycarboxlate-oxidoreductase, hydroxycarboxlate-viologen-oxidoreductase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.99 With unknown physiological acceptors

1.1.99.30 2-oxo-acid reductase

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Results	in table
1	Activating Compound
1	AA Sequence
6	Application
1	CAS Registry Number
6	Cofactor
7	Inhibitors
16	KM Value [mM]
4	Localization
5	Metals/Ions
6	Molecular Weight [Da]
9	Organism
5	pH Optimum
1	pI Value
4	Purification (Commentary)
4	Reaction
3	Reaction Type
9	Reference
3	Source Tissue
5	Specific Activity [micromol/min/mg]
5	Storage Stability
121	Substrates and Products (Substrate)
3	Subunits
16	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
2	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 1.1.99.30 - 2-oxo-acid reductase

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(2R)-hydroxy-carboxylate:acceptor oxidoreductase

Contains [4Fe-4S] and a mononucleotide molybdenum (pyranopterin) cofactor. Has broad substrate specificity, with 2-oxo-monocarboxylates and 2-oxo-dicarboxylates acting as substrates. Branching in a substrate at the C-3 position results in loss of activity. The enzyme from Proteus sp. is inactivated by oxygen.