1.1.99.27: (R)-pantolactone dehydrogenase (flavin)

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For detailed information about (R)-pantolactone dehydrogenase (flavin), go to the full flat file.

Reaction

Synonyms

(R)-Pantoyllactone dehydrogenase (flavin), 2-Dehydropantolactone reductase (flavin), 2-Dehydropantoyl-lactone reductase (flavin), dehydrogenase, L-(+)-pantoyllactone

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.99 With unknown physiological acceptors

                1.1.99.27 (R)-pantolactone dehydrogenase (flavin)

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Results	in table
1	Activating Compound
1	AA Sequence
1	CAS Registry Number
1	Cofactor
2	General Stability
18	Inhibitors
1	KM Value [mM]
1	Localization
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
1	Organism
1	pH Optimum
1	Posttranslational Modification
1	Purification (Commentary)
1	Reaction
2	Reaction Type
1	Reference
1	Storage Stability
7	Substrates and Products (Substrate)
1	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 1.1.99.27 - (R)-pantolactone dehydrogenase (flavin)

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SYSTEMATIC NAME

IUBMB Comments

(R)-pantolactone:acceptor oxidoreductase (flavin-containing)

High specificity for (R)-pantolactone. Phenazine methosulfate (PMS) can act as acceptor. The enzyme has been studied in the bacterium Nocardia asteroides and shown to be membrane-bound and induced by 1,2-propanediol. The FMN cofactor is non-covalently bound.