1.1.99.24: hydroxyacid-oxoacid transhydrogenase

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For detailed information about hydroxyacid-oxoacid transhydrogenase, go to the full flat file.

Word Map on EC 1.1.99.24

1.1.99.24

gamma-hydroxybutyrate

semialdehyde

2-hydroxyglutarate

iron-containing

acidurias

oncometabolite

2-ketoglutarate

diagnostics

Reaction

Synonyms

ADHFE1, alcohol dehydrogenase iron containing 1, HOT, hydroxyacid-oxoacid transhydrogenase, iron-dependent alcohol dehydrogenase ADHFe1, transhydrogenase, hydroxy acid-oxo acid

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.99 With unknown physiological acceptors

1.1.99.24 hydroxyacid-oxoacid transhydrogenase

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Results	in table
1	Activating Compound
3740	AA Sequence
1	Application
1	CAS Registry Number
1	Cloned(Commentary)
6	Cofactor
65	Disease/ Diagnostics
1	Expression
2	General Information
1	General Stability
2	IC50 Value
4	Inhibitors
2	Ki Value [mM]
22	KM Value [mM]
3	Localization
2	Metals/Ions
4	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
196	Organism
5	pH Optimum
1	pI Value
3	Purification (Commentary)
1	Reaction
5	Reaction Type
34	Reference
23	Source Tissue
5	Specific Activity [micromol/min/mg]
39	Substrates and Products (Substrate)
2	Subunits
36	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

Purification

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Purification on EC 1.1.99.24 - hydroxyacid-oxoacid transhydrogenase

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1300fold, partial from liver

Rattus norvegicus

664967

native enzyme from liver 1300fold by precipitation using PEG 6000, anion exchange and hydrophobic interaction chromatography, and gel filtration

partial