1.1.99.21: D-sorbitol dehydrogenase (acceptor)
This is an abbreviated version!
For detailed information about D-sorbitol dehydrogenase (acceptor), go to the full flat file.
Word Map on EC 1.1.99.21
Reaction
Synonyms
D-sorbitol dehydrogenase, FAD-SLDH, GoSLDH, mSLDH, PQQ-dependent D-sorbitol dehydrogenase, SDH, SLDH, sldhAB, sorbitol dehydrogenase
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1.1.99.21 D-sorbitol dehydrogenase (acceptor)Advanced search results
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Natural Substrates Products on EC 1.1.99.21 - D-sorbitol dehydrogenase (acceptor)
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-sorbitol + acceptor
L-sorbose + reduced acceptor
-
high specificity
-
-
?
D-sorbitol + acceptor
L-sorbose + reduced acceptor
D-sorbitol is oxidized in the periplasm in a chemo-, regio-, and stereoselective manner to L-sorbose by the membrane-bound dehydrogenase
the oxidation product accumulates in the culture medium
-
?
D-sorbitol + acceptor
L-sorbose + reduced acceptor
D-sorbitol is oxidized in the periplasm in a chemo-, regio-, and stereoselective manner to L-sorbose by the membrane-bound dehydrogenase
the oxidation product accumulates in the culture medium
-
?
L-glucitol + NAD+
D-sorbose + NADH + H+
-
90% conversion
-
-
?
additional information
?
-
-
production of 5-keto-D-gluconate is solely dependent on enzyme
-
-
?
additional information
?
-
-
this SLDH is distinguished from other L-sorbose-producing enzymes by its high activity and substrate specificity. Isothermal titration calorimetry shows that the protein binds more strongly to D-sorbitol than other L-sorbose-producing enzymes, and substrate docking analysis confirms a higher turnover rate
-
-
?
additional information
?
-
-
this SLDH is distinguished from other L-sorbose-producing enzymes by its high activity and substrate specificity. Isothermal titration calorimetry shows that the protein binds more strongly to D-sorbitol than other L-sorbose-producing enzymes, and substrate docking analysis confirms a higher turnover rate
-
-
?
