1.1.98.3: decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase

This is an abbreviated version!
For detailed information about decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.98.3

1.1.98.3

tuberculosis

mycobacterium

antitubercular

benzothiazinones

antimycobacterial

antituberculosis

pbtz169

arabinans

arabinogalactan

anti-tb

corynebacterineae

drug-susceptible

xdr-tb

1,2,3-triazole

tca1

dinitrobenzamides

nitroso

analysis

Reaction

trans,octacis-decaprenylphospho-beta-D-ribofuranose

+

FAD

=

trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose

+

FADH2

Synonyms

decaprenylphospho-beta-D-ribofuranose 2-oxidase, decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase, decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase, decaprenylphosphoryl-beta-D-ribose 2'-epimerase, decaprenylphosphoryl-beta-D-ribose 2'-oxidase, decaprenylphosphoryl-beta-D-ribose 2-epimerase, decaprenylphosphoryl-beta-D-ribose oxidase, decaprenylphosphoryl-beta-D-ribose-2'-epimerase, decaprenylphosphoryl-D-ribose oxidase, DprE1, DprE2, MSMEG_6382, Rv3790

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.98 With other, known, physiological acceptors

1.1.98.3 decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase

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Results	in table
190	AA Sequence
2	Application
7	Cloned(Commentary)
11	Cofactor
3	Crystallization (Commentary)
4	General Information
99	IC50 Value
171	Inhibitors
1	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
143	Organism
1	Pathway
16	PDB ID
17	Protein Variants
1	Purification (Commentary)
1	Reaction
32	Reference
25	Substrates and Products (Substrate)
2	Subunits
48	Synonyms
1	Systematic Name

IC50 Value

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IC50 Value on EC 1.1.98.3 - decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase

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0.00026

(3,4-dihydroisoquinolin-2(1H)-yl)[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone

Mycobacterium tuberculosis

at pH 7.5 and 22°C

0.0017

(4-(2-methoxyethyl)piperazin-1-yl)(6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)methanone

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0012

(4-benzylpiperazin-1-yl)[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone

Mycobacterium tuberculosis

at pH 7.5 and 22°C

0.0017

(4-methylpiperidin-1-yl)[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone

Mycobacterium tuberculosis

at pH 7.5 and 22°C

0.00012

(5-chloro-1-methyl-1H-pyrazol-4-yl)(3-endo-3-((5-fluoro-1H-indazol-3-yl)amino)-8-azabicyclo[3.2.1]oct-8-yl)methanone

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.078

(5-chloro-1-methyl-1H-pyrazol-4-yl)(4-((2-methoxyquinolin-4-yl)amino)piperidin-1-yl)methanone

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.00013

(5-chloro-1-methyl-1H-pyrazol-4-yl)(4-((5-fluoro-1H-indazol-3-yl)amino)piperidin-1-yl)methanone

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.01

(5-chloro-1-methyl-1H-pyrazol-4-yl)(4-(cinnolin-4-ylamino)-piperidin-1-yl)methanone

Mycobacterium tuberculosis

IC50 above 0.01 mM, at pH 8.5 and 25°C

0.0022

(6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)(piperidin-1-yl)methanone

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0012

(S)-(2-(6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)-4,5-dihydrooxazol-4-yl)(pyrrolidin-1-yl)methanone

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.000654

(S)-(2-(7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)-4,5-dihydrooxazol-4-yl)(pyrrolidin-1-yl)methanone

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.00006

(S)-7-nitro-2-(1-oxo-1-(pyrrolidin-1-yl)propan-2-ylcarbamoyl)-5-(trifluoromethyl)benzo[d]thiazole 3-oxide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0012

(S)-N-(3-hydroxy-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0012

(S)-N-(4-hydroxy-1-oxo-1-(piperidin-1-yl)butan-2-yl)-6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.1

1,3-dimethyl-5-((3-(trifluoromethyl)benzylamino)methyl)-1Hpyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

IC50 above 0.1 mM, pH and temperature not specified in the publication

0.01

1-(6-methoxy-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-(3-(trifluoromethyl)benzyl)methanamine

Mycolicibacterium smegmatis

IC50 above 0.01 mM, pH and temperature not specified in the publication

0.1

1-[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidine-4-carbonyl]piperidine-4-carboxylic acid

Mycobacterium tuberculosis

IC50 above 0.1 mM, at pH 7.5 and 22°C

0.000276

2-(4,5-dihydrooxazol-2-yl)-7-nitro-5-(trifluoromethyl)benzo[d]thiazole 3-oxide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.000027

2-(4-(2-methoxyethyl)piperazine-1-carbonyl)-7-nitro-5-(trifluoromethyl)benzo[d]thiazole 3-oxide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0039

2-(6-methyl-7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)-4,5-dihydrooxazole

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0059

2-(methoxymethyl)-7-nitro-5-(trifluoromethyl)benzo[d]thiazole

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.1

2-(piperidine-1-carbonyl)-5-(trifluoromethyl)benzo[d]thiazole-7-carboxylic acid

Mycobacterium tuberculosis

IC50 above 0.1 mM, pH and temperature not specified in the publication

0.00161

2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4,5]dec-8-yl]-8-(1H-pyrrol-1-yl)-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one

Mycobacterium tuberculosis

at pH 7.5 and 30°C

0.00000425

2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4,5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one

Mycobacterium tuberculosis

at pH 7.5 and 30°C

0.00734

2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-(1H-pyrrol-1-yl)-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one

Mycobacterium tuberculosis

at pH 7.5 and 30°C

0.01

3,7-dimethyl-1-phenyl-5-((3-(trifluoromethyl)benzylamino)-methyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

IC50 above 0.01 mM, pH and temperature not specified in the publication

0.0026

3-(((3-methyl-6-oxo-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4-b]-pyridin-5-yl)methylamino)methyl)benzonitrile

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.0282

3-(2-(piperidine-1-carbonyl)-5-(trifluoromethyl)benzo[d]thiazol-7-yl)-1,2,3-oxadiazol-3-ium-5-olate

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0005

3-cyclopropyl-1-phenyl-5-(((6-(trifluoromethyl)pyridin-2-yl)-methylamino)methyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.00004

3-cyclopropyl-1-phenyl-5-((3-(trifluoromethyl)benzylamino)-methyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.00001

3-cyclopropyl-5-(((3-methyl-6-(trifluoromethyl)pyridin-2-yl)-methylamino)methyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.000005

3-cyclopropyl-5-((2-fluoro-3-(trifluoromethyl)benzylamino)-methyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.00007

3-cyclopropyl-5-((2-fluoro-5-(trifluoromethyl)benzylamino)-methyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.00001

3-cyclopropyl-5-((2-methyl-5-(trifluoromethyl)benzylamino)-methyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.000005

3-isopropyl-5-((2-methyl-5-(trifluoromethyl)benzylamino)-methyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.0006

3-methyl-1-p-tolyl-5-((3-(trifluoromethyl)benzylamino)methyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.0004

3-methyl-1-phenyl-5-((3-(trifluoromethyl)benzylamino)methyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.0062

3-methyl-1-phenyl-5-((7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.000007

3-methyl-5-((2-methyl-5-(trifluoromethyl)benzylamino)methyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.0028

3-methyl-5-((3-methylbenzylamino)methyl)-1-phenyl-1Hpyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.00006

3-methyl-5-((methyl(3-(trifluoromethyl)benzyl)amino)methyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.001

3-methyl-6-oxo-1-phenyl-N-(3-(trifluoromethyl)benzyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.000007

4-(((1R,3R,5S)-8-((4,5-dimethylisoxazol-3-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6,7-difluoroquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000026

4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-1-methyl-1,8-naphthyridin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000008

4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6,7-difluoro-1-methylquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000012

4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-fluoro-1-methylquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.00003

4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-fluoroquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000053

4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-phenylpyridin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.043

4-(((1R,3S,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-fluoroquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000021

4-(((2S,4R)-1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-2-methylpiperidin-4-yl)amino)-6,7-difluoroquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000026

4-(((2S,4R)-1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-2-methylpiperidin-4-yl)amino)quinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.01

4-(((2S,4S)-1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-2-methylpiperidin-4-yl)amino)quinolin-2(1H)-one

Mycobacterium tuberculosis

IC50 above 0.01 mM, at pH 8.5 and 25°C

0.000011

4-((1-((1,5-dimethyl-1H-1,2,3-triazol-4-yl)carbonyl)piperidin-4-yl)amino)-6-fluoroquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.00021

4-((1-((1,5-dimethyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)-amino)quinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.0022

4-((1-((1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-quinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000018

4-((1-((4,5-dimethyl-1,2-oxazol-3-yl)carbonyl)piperidin-4-yl)-amino)-6,7-difluoroquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000038

4-((1-((4,5-dimethylisoxazol-3-yl)carbonyl)piperidin-4-yl)amino)-6,7-difluoro-1-methylquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000006

4-((1-((4,5-dimethylisoxazol-3-yl)carbonyl)piperidin-4-yl)amino)-6-fluoroquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000045

4-((1-((5-chloro-1-ethyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)-amino)-6-fluoroquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.007

4-((1-((5-chloro-1-isopropyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)quinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.0018

4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)azetidin-3-yl)amino)quinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.1

4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-1-ethylquinolin-2(1H)-one

Mycobacterium tuberculosis

IC50 above 0.1 mM, at pH 8.5 and 25°C

0.00014

4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-1-methylquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.00002

4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-6,7-difluoro-1-methylquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000006

4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-6,7-difluoroquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000005

4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-6-fluoroquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.003

4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-6-phenylpyridin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000009

4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-7,8-difluoroquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000007

4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-7-fluoroquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000011

4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-8-fluoroquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.018

4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)methylamino)quinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.008

4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)oxy)quinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.0047

4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)pyrrolidin-3-yl)amino)quinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000247

4-((2-methoxyethyl)piperazin-1-yl)(7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)methanone

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.000017

4-((3-endo-8-((4,5-Dimethyl-1,2-oxazol-3-yl)carbonyl)-8-azabicyclo[3.2.1]oct-3-yl)amino)-6,7-difluoro-1-methylquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.000009

4-((3-endo-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]oct-3-yl)amino)-6,7-difluoroquinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.0052

4-((7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)morpholine

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0012

5-((3,4-dimethylbenzylamino)methyl)-3-methyl-1-phenyl-1Hpyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.002

5-((3-fluorobenzylamino)methyl)-3-methyl-1-phenyl-1Hpyrazolo[3,4-b]pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.0014

5-((benzylamino)methyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]-pyridin-6(7H)-one

Mycolicibacterium smegmatis

pH and temperature not specified in the publication

0.000021

6-fluoro-4-((1-((1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-carbonyl)piperidin-4-yl)amino)quinolin-2(1H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.0012

6-methyl-7-nitro-N-(pyridin-2-ylmethyl)-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.000095

7-nitro-2-(piperidine-1-carbonyl)-5-(trifluoromethyl)benzo[d]thiazole 3-oxide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0018

7-nitro-2-(piperidine-1-carbonyl)benzo[d]thiazole-5-carbonitrile

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.000026

7-nitro-2-(pyridin-2-ylmethylcarbamoyl)-5-(trifluoromethyl)benzo[d]thiazole 3-oxide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.000213

7-nitro-5-((trifluoromethyl)-1,3-benzothiazol-2-yl)-piperidin-1-ylmethanone

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.000452

7-nitro-N-(pyridin-2-ylmethyl)-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.000183

8-((3-endo-8-((4,5-dimethyl-1,2-oxazol-3-yl)carbonyl)-8-azabicyclo[3.2.1]oct-3-yl)amino)-5-methylpyrido[2,3-b]pyrazin-6(5H)-one

Mycobacterium tuberculosis

at pH 8.5 and 25°C

0.0036

ethyl 1-[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidine-4-carbonyl]piperidine-4-carboxylate

Mycobacterium tuberculosis

at pH 7.5 and 22°C

0.0003

morpholino(7-nitro-5-(trifluoromethyl)benzo[d]thiazol-2-yl)methanone

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.021

N,N-dimethyl-1-[1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidine-4-carbonyl]piperidine-4-carboxamide

Mycobacterium tuberculosis

at pH 7.5 and 22°C

0.1

N-(pyridin-2-ylmethyl)-5-(trifluoromethyl)benzo[d]thiazole-2-carboxamide

Mycobacterium tuberculosis

IC50 above 0.1 mM, pH and temperature not specified in the publication

0.053

N-methyl-7-nitro-2-(piperidine-1-carbonyl)benzo[d]thiazole-5-carboxamide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.000349

N-[(2S)-3-hydroxy-1-oxo-1-pyrrolidin-1-ylpropan-2-yl]-7-nitro-5-(trifluoromethyl)-1,3-benzothiazole-2-carboxamide

Mycobacterium tuberculosis

pH and temperature not specified in the publication

0.0004

[4-[(2H-1,3-benzodioxol-5-yl)methyl]piperazin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone

Mycobacterium tuberculosis

at pH 7.5 and 22°C

0.000054

[4-[(4-fluorophenyl)methyl]piperidin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone

Mycobacterium tuberculosis

at pH 7.5 and 22°C

0.1

[4-[(methylamino)methyl]piperidin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone

Mycobacterium tuberculosis

IC50 above 0.1 mM, at pH 7.5 and 22°C

0.0026

[4-[(pyridin-2-yl)methyl]piperidin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone

Mycobacterium tuberculosis

at pH 7.5 and 22°C

0.00044

[4-[(pyridin-3-yl)methyl]piperidin-1-yl][1-[5-(1H-pyrrol-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-4-yl]methanone

Mycobacterium tuberculosis

at pH 7.5 and 22°C

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Release 2023.1 (January 2023)