1.1.98.2: glucose-6-phosphate dehydrogenase (coenzyme-F420)

This is an abbreviated version!
For detailed information about glucose-6-phosphate dehydrogenase (coenzyme-F420), go to the full flat file.

Reaction

Synonyms

Rv0407, coenzyme F420-dependent glucose-6-phosphate dehydrogenase, EC 1.1.99.34, F420-dependent glucose-6-phosphate dehydrogenase, FGD, FGD1, glucose-6-phosphate dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.98 With other, known, physiological acceptors

                1.1.98.2 glucose-6-phosphate dehydrogenase (coenzyme-F420)

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Results	in table
2402	AA Sequence
1	Application
2	CAS Registry Number
7	Cloned(Commentary)
19	Cofactor
3	Crystallization (Commentary)
4	General Information
1	IC50 Value
2	Inhibitors
16	kcat/KM [mM/s]
18	KM Value [mM]
1	Metals/Ions
4	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
621	Organism
2	PDB ID
18	pH Optimum
1	pH Range
8	Protein Variants
6	Purification (Commentary)
1	Reaction
42	Reference
15	Specific Activity [micromol/min/mg]
2	Storage Stability
49	Substrates and Products (Substrate)
3	Subunits
44	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
2	Temperature Stability [°C]
16	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.1.98.2 - glucose-6-phosphate dehydrogenase (coenzyme-F420)

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

D-glucose 6-phosphate + oxidized coenzyme F420

6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420

4 entries

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

33 entries

additional information

?

-

Mycolicibacterium smegmatis

-

intracellular glucose-6-phosphate in mycobacteria serves as a source of reducing power, and with the mycobacteria-specific F420-dependent glucose-6-phosphate dehydrogenase/F420 system, plays a protective role against oxidative stress imposed by host macrophages

699008

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420

Mycobacterium tuberculosis

-

-

723589

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420

Mycobacterium tuberculosis

Q0RVH7

-

740083

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420

Mycobacterium tuberculosis H37Rv

-

-

723589

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420

Rhodococcus jostii

-

-

739925

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Gordonia amarae

-

-

697967

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Gordonia amarae

-

there are two separate glucose-6-phosphate dehydrogenase activities in Gordona amarae: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium avium

-

-

697967

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium avium

-

there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium avium: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium gordonae

-

-

697967

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium gordonae

-

there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium gordonae: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium kansasii

-

-

697967

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium kansasii

-

there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium kansasii: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium leprae

-

-

697967

-

-

?, ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium scrofulaceum

-

-

697967

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium scrofulaceum

-

there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium scrofulaceum: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis

-

-

697967, 701052

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis

-

there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Ra: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis

-

there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Rv: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis H37Ra / ATCC 25177

-

-

697967

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis H37Ra / ATCC 25177

-

there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Ra: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis H37Ra / ATCC 25177

-

there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Rv: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis H37Rv

-

-

697967

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis H37Rv

-

there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Ra: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis H37Rv

-

there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Rv: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycobacterium tuberculosis H37Rv

-

-

701052

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycolicibacterium fortuitum

-

-

697967

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycolicibacterium fortuitum

-

there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium fortuitum: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycolicibacterium smegmatis

-

-

697967

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycolicibacterium smegmatis

-

there are to separate glucose-6-phosphate dehydrogenase activities in Mycobacterium smegmatis: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

698547

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Mycolicibacterium smegmatis

-

there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium smegmatis: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Nocardia asteroides

-

-

697967

-

-

?, ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Nocardia brasiliensis

-

-

697967

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Nocardia brasiliensis

-

there are two separate glucose-6-phosphate dehydrogenase activities in Nocardia brasiliensis: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Nocardia otitidiscaviarum

-

-

697967

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Nocardia otitidiscaviarum

-

there are two separate glucose-6-phosphate dehydrogenase activities in Nocardia otitidiscaviarum: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Nocardia tartaricans

-

-

697967

-

-

?

D-glucose 6-phosphate + oxidized coenzyme F420

D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420

Nocardia tartaricans

-

there are two separate glucose-6-phosphate dehydrogenase activities in Nocardia tartaricans: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)

697967

-

-

ir