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1.1.98.2: glucose-6-phosphate dehydrogenase (coenzyme-F420)

This is an abbreviated version!
For detailed information about glucose-6-phosphate dehydrogenase (coenzyme-F420), go to the full flat file.

Word Map on EC 1.1.98.2

Reaction

D-glucose 6-phosphate
+
oxidized coenzyme F420
=
6-phospho-D-glucono-1,5-lactone
 +
reduced coenzyme F420

Synonyms

Rv0407, coenzyme F420-dependent glucose-6-phosphate dehydrogenase, EC 1.1.99.34, F420-dependent glucose-6-phosphate dehydrogenase, FGD, FGD1, glucose-6-phosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.98 With other, known, physiological acceptors
                1.1.98.2 glucose-6-phosphate dehydrogenase (coenzyme-F420)

Engineering

Engineering on EC 1.1.98.2 - glucose-6-phosphate dehydrogenase (coenzyme-F420)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E109Q
the mutant has 60fold decreased catalytic efficiency compared to the wild type enzyme
H40A
the mutant has 1000fold decreased catalytic efficiency compared to the wild type enzyme
W44A
the mutant has 2000fold decreased catalytic efficiency compared to the wild type enzyme
W44F
the mutant has 2fold increased catalytic efficiency compared to the wild type enzyme
W44Y
the mutant has 34fold decreased catalytic efficiency compared to the wild type enzyme
K197N
-
the mutant shows strongly reduced catalytic efficiency compared to the wild type enzyme
K258N
-
the mutant shows strongly reduced catalytic efficiency compared to the wild type enzyme
R282Q
-
the mutant shows severely reduced catalytic efficiency compared to the wild type enzyme