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1.1.5.9: glucose 1-dehydrogenase (FAD, quinone)

This is an abbreviated version!
For detailed information about glucose 1-dehydrogenase (FAD, quinone), go to the full flat file.

Word Map on EC 1.1.5.9

Reaction

D-glucose
+
a quinone
=
D-glucono-1,5-lactone
+
a quinol

Synonyms

D-glucose:acceptor 1-oxidoreductase, dehydrogenase, glucose (acceptor), dehydrogenase, glucose (Aspergillus), EC 1.1.99.10, FAD dependent glucose dehydrogenase, FAD glucose dehydrogenase, FAD-dependent GDH, FAD-dependent glucose dehydrogenase, FAD-GDH, FAD-glucose dehydrogenase, FAD-glucose dehydrogenases, FADGDH, FADGH, flavin adenine dinucleotide dependent glucose dehydrogenase, flavin adenine dinucleotide-dependent glucose dehydrogenase, GDH, GDH-FAD, GLD, glucose dehydrogenase, glucose dehydrogenase (Aspergillus), glucose dehydrogenase (decarboxylating), thermostable GDH, thermostable glucose dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                1.1.5.9 glucose 1-dehydrogenase (FAD, quinone)

Substrates Products

Substrates Products on EC 1.1.5.9 - glucose 1-dehydrogenase (FAD, quinone)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-deoxy-D-glucose + 2,6-dichlorophenolindophenol
2-deoxy-D-glucono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
2-deoxy-D-glucose + a quinone
2-deoxy-D-glucono-1,5-lactone + a quinol
show the reaction diagram
-
-
-
-
?
alpha,alpha-trehalose + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
0.5% activity compared to D-glucose
-
-
?
beta-D-glucose + Fe(CN)63-
D-glucono-1,5-lactone + Fe(CN)64-
show the reaction diagram
-
-
-
-
?
cellobiose + a quinone
? + a quinol
show the reaction diagram
-
low activity
-
-
?
D-galactose + 2,6-dichlorophenolindophenol
D-galactono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
D-galactose + acceptor
D-galactono-1,5-lactone + reduced acceptor
show the reaction diagram
-
6.5% of the activity with D-glucose
-
-
?
D-glucose + 1,2-naphthoquinone
D-glucono-1,5-lactone + 1,2-naphthoquinol
show the reaction diagram
-
an electrochemical method is applied to evaluate the bimolecular rate constants of selected electron acceptors. With regard to the formal potential, higher kcat/Km values are found for ortho-quinones (including 9,10-phenanthrenequinone and 1,2-naphthoquinone) than for para-quinones in the reaction with FAD-GDH. Thus, the mechanism for effective electron transfer can be explained by steric hindrance (the electron transfer distance between the FAD site and the redox site of the quinone molecules)
-
-
?
D-glucose + 1,4-benzoquinone
D-glucono-1,5-lactone + 1,4-benzoquinol
show the reaction diagram
D-glucose + 1,4-naphthoquinone
D-glucono-1,5-lactone + 1,4-naphthoquinol
show the reaction diagram
-
-
-
-
?
D-glucose + 1,6-pyrenedione
D-glucono-1,5-lactone + 1,6-pyrenediol
show the reaction diagram
-
the electro-oxidation of pyrene forms an efficient mediator for the enzyme (FAD-GDH) which surpasses currently used mediators like naphthoquinone in terms of electrocatalytic current densities and stability
-
-
?
D-glucose + 1,8-pyrenedione
D-glucono-1,5-lactone + 1,8-pyrenediol
show the reaction diagram
-
the electro-oxidation of pyrene forms an efficient mediator for the enzyme (FAD-GDH) which surpasses currently used mediators like naphthoquinone in terms of electrocatalytic current densities and stability
-
-
?
D-glucose + 2,6-dichlorophenolindophenol
D-gluconic acid + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
D-glucose + 2,6-dichlorophenolindophenol
D-glucono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
D-glucose + 9,10-phenanthrenequinone
D-glucono-1,5-lactone + 9,10-phenanthrenequinol
show the reaction diagram
-
an electrochemical method is applied to evaluate the bimolecular rate constants of selected electron acceptors. With regard to the formal potential, higher kcat/Km values are found for ortho-quinones (including 9,10-phenanthrenequinone and 1,2-naphthoquinone) than for para-quinones in the reaction with FAD-GDH. Thus, the mechanism for effective electron transfer can be explained by steric hindrance (the electron transfer distance between the FAD site and the redox site of the quinone molecules)
-
-
?
D-glucose + a quinone
D-glucono-1,5-lactone + a quinol
show the reaction diagram
D-glucose + a quinone
D-glucono-1,5-lactone + a reduced quinol
show the reaction diagram
D-glucose + acceptor
D-glucono-1,5-lactone + reduced acceptor
show the reaction diagram
-
-
-
-
?
D-glucose + coenzyme Q1
D-glucono-1,5-lactone + reduced coenzyme Q1
show the reaction diagram
-
-
-
-
?
D-glucose + ferricenium hexafluorophosphate
D-glucono-1,5-lactone + ferrocenium hexafluorophosphate
show the reaction diagram
D-glucose + ferricenium ion
D-glucono-1,5-lactone + ferrocenium ion
show the reaction diagram
-
-
-
-
?
D-glucose + ferricyanide
D-glucono-1,5-lactone + ferrocyanide
show the reaction diagram
D-glucose + menadione
D-glucono-1,5-lactone + menadiol
show the reaction diagram
-
-
-
-
?
D-glucose + oxidized 2,6-dichlorophenol indophenol
D-glucono-1,5-lactone + reduced 2,6-dichlorophenol indophenol
show the reaction diagram
D-glucose + phenazine methosulfate
D-glucono-1,5-lactone + reduced phenazine methosulfate
show the reaction diagram
D-glucose + tetramethyl-p-phenylenediamine
D-glucono-1,5-lactone + reduced tetramethyl-p-phenylenediamine
show the reaction diagram
-
-
-
-
?
D-lactose + 2,6-dichlorophenolindophenol
D-lactono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
D-maltose + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
-
-
-
?
D-maltose + acceptor
?
show the reaction diagram
-
-
-
-
?
D-mannose + acceptor
D-manno-1,5-lactone + reduced acceptor
show the reaction diagram
-
8.6% of the activity with D-glucose
-
-
?
D-raffinose + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
D-xylose + 2,6-dichloroindophenol
D-xylono-1,5-lactone + 2,6-dichlorophenolindophenol
show the reaction diagram
D-xylose + 2,6-dichlorophenolindophenol
D-xylono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
D-xylose + acceptor
D-xylono-1,5-lactone + reduced acceptor
show the reaction diagram
-
13% of the activity with D-glucose
-
-
?
D-xylose + ferricenium ion
D-xylono-1,5-lactone + ferrocenium ion
show the reaction diagram
-
-
-
-
?
D-xylose + oxidized 2,6-dichlorophenol indophenol
D-xylono-1,5-lactone + reduced 2,6-dichlorophenol indophenol
show the reaction diagram
fructose + 2,6-dichlorophenolindophenol
?
show the reaction diagram
-
8% of the activity with D-glucose
-
-
?
glutamine + a quinone
? + a quinol
show the reaction diagram
-
low activity
-
-
?
L-arabinose + 2,6-dichlorophenolindophenol
L-arabinono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
1.5% activity compared to D-glucose
-
-
?
L-arabinose + acceptor
L-arabinono-1,5-lactone + reduced acceptor
show the reaction diagram
-
2.8% of the activity with D-glucose
-
-
?
L-rhamnose + acceptor
L-rhamnone-1,5-lactone + reduced acceptor
show the reaction diagram
-
7.5% of the activity with D-glucose
-
-
?
maltose + 2,6-dichlorophenol indophenol
maltono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
maltose + 2,6-dichlorophenolindophenol
maltono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
maltose + acceptor
?
show the reaction diagram
-
3.2% of the activity with D-glucose
-
-
?
maltotetraose + 2,6-dichlorophenolindophenol
maltotetraono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
0.66% activity compared to D-glucose
-
-
?
maltotriose + 2,6-dichlorophenolindophenol
maltotriono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
mannose + 2,6-dichlorophenolindophenol
mannono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
0.66% activity compared to D-glucose
-
-
?
trehalose + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
0.22% activity compared to D-glucose
-
-
?
additional information
?
-