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1.1.5.4: malate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about malate dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.1.5.4

Reaction

(S)-malate
+
a quinone
=
oxaloacetate
 +
reduced quinone

Synonyms

EC 1.1.3.3, EC 1.1.99.16, FAD-dependent malate dehydrogenase, L-malate-quinone oxidoreductase, L-malate:quinone oxidoreductase, malate dehydrogenase, malate dehydrogenase (acceptor), malate-quinone oxidoreductase, malate-vitamin K reductase, malate: quinone oxidoreductase, malate:quinine oxidoreductase, malate:quinone oxidoreductase, malate:quinone reductase, menaquinone reductase, Mqo, MqoB, MQR, PfMQO

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                1.1.5.4 malate dehydrogenase (quinone)

Inhibitors

Inhibitors on EC 1.1.5.4 - malate dehydrogenase (quinone)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(S)-malate
-
in the presence of polymyxin B, enzyme kinetics changes from the Michaelis-Menten type to substrate inhibition kinetics with the substrate inhibition constant Ksi of 57.4 microg/ml
1,1'-[furan-2,5-diylbis(3-chloro-1,4-phenylene)]bisguanidine
inhibits growth of cultured parasite
-
2-cycloheptyl-5-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4,4-dimethylpyrazol-3-one
inhibits growth of cultured parasite
-
2-[3-chloro-4-[5-[2-chloro-4-(diaminomethylideneamino)phenyl]furan-2-yl]phenyl]guanidine
inhibits growth of cultured parasite
-
3-cycloheptyl-4abeta,5,8,8abeta-tetrahydro-1-[3-[4-[4-(2H-tetrazole-5-yl)phenoxy]butoxy]-4-methoxyphenyl]phthalazine-4(3H)-one
inhibits growth of cultured parasite
-
3-[7-[(3,5-dimethylbenzyl)oxy]-4,8-dimethyl-2-oxo-2H-chromen-3-yl]propanoic acid
-
-
5-bromo-2-chloro-N-(5-mercapto-1,3,4-thiadiazol-2-yl)benzamide
-
-
AlCl3
1 mM, 30.1% of the activity without metal ion
CaCl2
1 mM, 72.8% of the activity without metal ion
CoCl2
CuCl2
CuSO4
-
completely inhibits the enzyme at 0.1 mM
ferulenol
inhibits parasite growth and shows strong synergism in combination with atovaquone, an anti-malarial and bc1 complex inhibitor
-
KCl
1 mM, 97.5% of the activity without metal ion
MgCl2
1 mM, 67.3% of the activity without metal ion
MnCl2
N-[2-(1H-indol-3-yl)ethyl]-2-oxo-2H-chromene-3-carboxamide
-
-
NaCl
1 mM, 95.3% of the activity without metal ion
NaN3
-
65% inhibition at 1 mM
nanaomycin A
-
naphthoquinone derivative
NiCl2
1 mM, 65.1% of the activity without metal ion
NiSO4
-
67% inhibition at 1 mM
Polymyxin B
-
cationic decapeptide. Primary site of action is the quinone-binding site, amino acid sequence is examined and possible binding sites for L-malate and quinones are found
pyridoxal 5'-phosphate
-
28% inhibition at 1 mM
Sodium amytal
-
1 mM, competitive with respect to phosphatidylethanolamine, noncompetitive with respect to FAD
ZnCl2
1 mM, 29.7% of the activity without metal ion
additional information
-
o-phenanthroline does not significantly affect activity
-