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1.1.5.12: D-lactate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about D-lactate dehydrogenase (quinone), go to the full flat file.

Reaction

(R)-lactate
+
a quinone
=
pyruvate
 +
a quinol

Synonyms

Cg1027, D-iLDH, DLD, Dld2, Fe-S D-iLDH, lldE, NAD-independent D-lactate dehydrogenase, pp4737, quinone-dependent D-lactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                1.1.5.12 D-lactate dehydrogenase (quinone)

Engineering

Engineering on EC 1.1.5.12 - D-lactate dehydrogenase (quinone)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
F12W
-
increase in activtiy
F176W
-
about 25% of wild-type vmax
F263W
-
loss of activity
F279W
-
loss of activity
F326W
-
loss of activity
F340W
-
about 35% of wild-type vmax
F361W
-
activity similar to wild-type
F39W
-
about 50% of wild-type vmax
F412W
-
loss of activity
F435W
-
about 25% of wild-type vmax
F490W
-
loss of activity
F544W
-
loss of activity
I152W
-
loss of activity
I193W
-
loss of activity
I99W
-
loss of activity
L110W
-
loss of activity
L203W
-
loss of activity
L456W
-
loss of activity
L517W
-
about 50% of wild-type vmax
Y243W
-
activity similar to wild-type
Y309W
-
loss of activity
Y388W
-
about 75% of wild-type vmax
C540S
[Fe-S]-cluster-to-protein ratio is reduced to 98% of wild-type
C540S/594S/C751S/C752S
[Fe-S]-cluster-to-protein ratio is reduced to 27.8% of wild-type
C540S/C543S/C594S/C751S/C752S/C540S/C594S
[Fe-S]-cluster-to-protein ratio is reduced to 1.1% of wild-type
C540S/C594S
[Fe-S]-cluster-to-protein ratio is reduced to 60.9% of wild-type
C540S/C594S/C751S/C752S/C540S/C594S
[Fe-S]-cluster-to-protein ratio is reduced to 9% of wild-type