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1.1.3.15: (S)-2-hydroxy-acid oxidase

This is an abbreviated version!
For detailed information about (S)-2-hydroxy-acid oxidase, go to the full flat file.

Word Map on EC 1.1.3.15

Reaction

an (S)-2-hydroxy carboxylate
+
O2
=
a 2-oxo carboxylate
 +
H2O2

Synonyms

(L)-2-HAOX, (S)-2-hydroxy-acid oxidase, peroxisomal, 2-hydroxy acid oxidase, CSUB_C1080, EC 1.1.3.1, GLO, Glo1, GLO3, Glo4, glycolate oxidase, GO, GO1, GOX, GOX1, GOX2, HAO1, Hao2, HAOX, HAOX1, HAOX2, HAOX3, hydroxy-acid oxidase A, hydroxy-acid oxidase B, hydroxyacid oxidase 1, hydroxyacid oxidase A, L-2-hydroxy acid oxidase, L-2-hydroxyacid oxidase A, L-alpha-hydroxy acid oxidase, L-amino acid oxidase, L-LAC-OX, L-lactate monooxygenase, L-lactate oxidase, L-LOx, lactate oxidase, LCHAO, LctO, lHAOX1, lHAOX2, long chain hydroxy acid oxidase, long chain l-2-hydroxy acid oxidase, long chain L-2-hydroxy acid oxidase 2, long-chain 2-hydroxy acid oxidase, long-chain L-alpha-hydroxy acid oxidase, LOX, More, NbS00005125g0015, NbS00060838g0004, Nbv5tr6245008, Os03g0786100, Os04g0623500, Os07g0616500, oxidase, L-2-hydroxy acid, RCOM_0631490, RCOM_0684800

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.3 With oxygen as acceptor
                1.1.3.15 (S)-2-hydroxy-acid oxidase

IC50 Value

IC50 Value on EC 1.1.3.15 - (S)-2-hydroxy-acid oxidase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0007 - 0.0108
3-benzyl-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0012
3-ethoxy-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0003 - 0.0054
3-ethyl-4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0095 - 0.0107
3-methyl-4-(2-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid
0.00427 - 427
3-methyl-4-(2-phenylethyl)-1H-pyrazole-5-carboxylic acid
0.0006 - 0.0124
3-methyl-4-(3-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid
0.0005 - 0.0104
3-methyl-4-(4-phenoxybenzyl)-1H-pyrazole-5-carboxylic acid
0.0002 - 0.0226
3-methyl-4-(naphthalen-1-ylmethyl)-1H-pyrazole-5-carboxylic acid
0.0011 - 0.00812
3-methyl-4-(naphthalen-2-ylmethyl)-1H-pyrazole-5-carboxylic acid
0.0017 - 0.0022
3-methyl-4-(quinolin-2-ylmethyl)-1H-pyrazole-5-carboxylic acid
0.0007 - 0.0023
3-methyl-4-[2-(trifluoromethoxy)benzyl]-1H-pyrazole-5-carboxylic acid
0.0013 - 0.0134
3-methyl-4-[2-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0004 - 0.0315
3-methyl-4-[3-(pyridin-3-yl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0003 - 0.0135
3-methyl-4-[3-(pyridin-4-yl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0003 - 0.00523
3-methyl-4-[3-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0013 - 0.0073
3-methyl-4-[4-(trifluoromethoxy)benzyl]-1H-pyrazole-5-carboxylic acid
0.00912 - 0.0357
3-methyl-4-[4-(trifluoromethyl)benzyl]-1H-pyrazole-5-carboxylic acid
0.0003 - 0.00634
3-methyl-4-[[4'-(trifluoromethoxy)biphenyl-3-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.002 - 0.0113
3-methyl-4-[[4'-(trifluoromethoxy)biphenyl-4-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0004 - 0.0083
3-methyl-4-[[4'-(trifluoromethyl)biphenyl-3-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0011 - 0.0051
3-methyl-4-[[4'-(trifluoromethyl)biphenyl-4-yl]methyl]-1H-pyrazole-5-carboxylic acid
0.0267 - 0.048
4-(1-benzofuran-2-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0003 - 0.0083
4-(1-benzothiophen-2-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0009 - 0.0088
4-(3-carbamoylbenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.003 - 0.0076
4-(3-carboxybenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0005 - 0.0062
4-(3-cyanobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0002 - 0.00113
4-(3-fluorobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.00095 - 0.0358
4-(4'-fluorobiphenyl-3-yl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0137 - 0.0196
4-(4'-fluorobiphenyl-4-yl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0008 - 11
4-(4-carbamoylbenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0032 - 0.0407
4-(4-carboxybenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0006 - 0.0339
4-(4-cyanobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0007 - 0.00714
4-(4-fluorobenzyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.00135 - 0.0031
4-(4-fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylic acid
0.0091
4-(biphenyl-3-ylmethyl)-3-methyl-1H-pyrazole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0009 - 0.0052
4-[(2'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0005 - 0.0205
4-[(3'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0002 - 0.0186
4-[(4'-carbamoylbiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0011 - 0.0032
4-[(4'-carboxybiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0003 - 0.0135
4-[(4'-cyanobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0116 - 0.0217
4-[(4'-fluorobiphenyl-2-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0003 - 0.0166
4-[(4'-fluorobiphenyl-3-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0004 - 0.01125
4-[(4'-fluorobiphenyl-4-yl)methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0009 - 0.0095
4-[2-(4'-fluorobiphenyl-3-yl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0009 - 0.0054
4-[2-(4'-fluorobiphenyl-4-yl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0052 - 0.0318
4-[2-(4-fluorophenyl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.00091
4-[2-(biphenyl-4-yl)ethyl]-3-methyl-1H-pyrazole-5-carboxylic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0004 - 0.0022
4-[[4'-(2-amino-2-oxoethyl)biphenyl-3-yl]methyl]-3-methyl-1H-pyrazole-5-carboxylic acid
0.0008 - 0.0042
4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-(2-phenylethyl)-1H-pyrazole-5-carboxylic acid
0.0005 - 0.0021
4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-(propan-2-yl)-1H-pyrazole-5-carboxylic acid
0.0011 - 0.0018
4-[[4-(4-fluorophenyl)pyridin-2-yl]methyl]-3-phenyl-1H-pyrazole-5-carboxylic acid
3.7
Mandelate
Homo sapiens
-
-
1.8
oxalate
Homo sapiens
-
-