1.1.1.86: ketol-acid reductoisomerase (NADP+) This is an abbreviated version! For detailed information about ketol-acid reductoisomerase (NADP+), go to the full flat file .
Reaction
(2R)-2,3-dihydroxy-3-methylbutanoate +
NADP+ =
(2S)-2-hydroxy-2-methyl-3-oxobutanoate +
NADPH +
H+
Synonyms 2-hydroxy-3-keto acid reductoisomerase, acetohydroxy acid isomeroreductase, acetohydroxy acid reductoisomerase, acetohydroxy-acid isomeroreductase , acetohydroxy-acid reductoisomerase , acetohydroxyacid isomeroreductase, acetolactate reductoisomerase, AHAIR, AHIR, alpha-keto-beta-hydroxylacil reductoisomerase, alpha-keto-beta-hydroxylacyl reductoisomerase, class II ketol-acid reductoisomerase, dehydrogenase, dihydroxyisovalerate (isomerizing), dihydroxyisovalerate dehydrogenase (isomerizing), EC 1.1.1.89, Icl1p, Ilv5p, ilvC, IlvC-PanE, IlvC1, IlvC2, isomerase, ketol acid reducto-, isomeroreductase, KARI, ketol-acid reductoisomerase, reductoisomerase
ECTree
Subunits
Subunits on EC 1.1.1.86 - ketol-acid reductoisomerase (NADP+)
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dimer
2 * 36000, SDS-PAGE
dimer
-
2 * 36000, SDS-PAGE
-
dimer
-
2 * 59000, SDS-PAGE
dimer
structure-function relationship, effects of ligand, Mg2+ and NADPH, binding on the enzyme conformation, overview
dimer
-
2 * 57000, SDS-PAGE
dimer
-
2 * 56850, calculation from acid sequence
dimer
-
2 * 120000, Arabidopsis thaliana acetohydroxy acid synthase genetically fused in frame with the nucleotide sequence coding for the Spinacia oleracea acetohydroxy acid isomeroreductase and expressed in Escherichia coli, SDS-PAGE
dimer
the enzyme retains dimeric arrangement in solution
dodecamer
-
-
dodecamer
-
the dodecameric architecture is assembled by six dimeric units which are positioned on the tetrahedron edges to form a tetrahedron with T symmetry
homodimer
2 * 37155, mass spectrometry
homodimer
-
2 * 37155, mass spectrometry
-
monomer
1 * 40000, SDS-PAGE
monomer
1 * 39000, calculated from amino acid sequence
monomer
-
1 * 40000, SDS-PAGE
-
monomer
-
1 * 39000, calculated from amino acid sequence
-
tetramer
-
three-dimensional enzyme structure, subunit domain structures, surface contact and interlock, crystal structure analysis, overview
tetramer
4 * 52428, calculated
tetramer
-
4 * 57000, equilibrium sedimentation after treatment with 0.1 M 2-mercaptoethanol and 6 M guanidine hydrochloride
tetramer
-
4 * 59000, SDS-PAGE