1.1.1.85: 3-isopropylmalate dehydrogenase

This is an abbreviated version!
For detailed information about 3-isopropylmalate dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-hydroxy-4-methyl-3-carboxyvalerate:NAD+ oxidoreductase, 2R,3S-isopropylmalate:NAD+ oxidoreductase (decaboxylating), 3-IPM dehydrogenase, 3-IPM-DH, 3-isopropylmalate dehydrogenase, 3-isopropylmalateDH, APS IPMDH, beta-IPM dehydrogenase, beta-IPMDH, beta-isopropylmalate dehydrogenase, beta-isopropylmalic enzyme, Bs3-isopropylmalateDH, dehydrogenase, 3-isopropylmalate, IMDH, IPMDH, IPMDH1, IPMDH2, IPMDH3, isopropylmalate dehydrogenase, leuB, NAD-dependent isopropylmalate dehydrogenase, Saci_0600, SbIPMDH, SoIPMDH, threo-Ds-3-isopropylmalate dehydrogenase, Tt-beta-3-isopropylmalateDH, two-domain 3-isopropylmalate dehydrogenase, Ydr417cp

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.85 3-isopropylmalate dehydrogenase

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Results	in table
1	Activating Compound
36146	AA Sequence
5	Application
1	CAS Registry Number
61	Cloned(Commentary)
108	Cofactor
27	Crystallization (Commentary)
2	Expression
23	General Information
8	General Stability
44	Inhibitors
66	kcat/KM [mM/s]
2	Ki Value [mM]
293	KM Value [mM]
3	Localization
73	Metals/Ions
30	Molecular Weight [Da]
34	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
236	Organism
7	Pathway
116	PDB ID
24	pH Optimum
2	pH Range
2	pH Stability
1	pI Value
2	Posttranslational Modification
156	Protein Variants
32	Purification (Commentary)
2	Reaction
3	Reaction Type
164	Reference
4	Renatured (Commentary)
7	Source Tissue
26	Specific Activity [micromol/min/mg]
4	Storage Stability
197	Substrates and Products (Substrate)
54	Subunits
170	Synonyms
1	Systematic Name
26	Temperature Optimum [°C]
4	Temperature Range [°C]
37	Temperature Stability [°C]
224	Turnover Number [1/s]

Temperature Range

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Temperature Range on EC 1.1.1.85 - 3-isopropylmalate dehydrogenase

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TEMPERATURE RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

20 - 40

Escherichia coli

-

the van ’t Hoff plot of Km IPM shows sigmoid-like transition within this range

696778

25 - 50

synthetic construct

-

although the ancestral IPMDHs (ancIPMDH-IQ and ancIPMDH-ML) are slightly less catalytically active relative to the mesophilic IPMDHs, they are more active than the thermophilic IPMDH at temperatures ranging from 25 to 50°C. ancIPMDH-IQ and ancIPMDH-ML functioned optimally at 70-80°C and maintain, respectively, 7% and 4% of their maximum activities at 25°C

763696

25 - 95

Sulfurisphaera tokodaii

P50455

2% of maximal activity at 25°C, maximal activity at 95°C

701046

40 - 80

Escherichia coli

-

40°C: about 45% of maximal activity, 80°C: about 85% of maximal activity

639164