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1.1.1.85: 3-isopropylmalate dehydrogenase

This is an abbreviated version!
For detailed information about 3-isopropylmalate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.85

Reaction

(2R,3S)-3-isopropylmalate
+
NAD+
=
(2S)-2-isopropyl-3-oxosuccinate
+
NADH
+
H+

Synonyms

2-hydroxy-4-methyl-3-carboxyvalerate:NAD+ oxidoreductase, 2R,3S-isopropylmalate:NAD+ oxidoreductase (decaboxylating), 3-IPM dehydrogenase, 3-IPM-DH, 3-isopropylmalate dehydrogenase, 3-isopropylmalateDH, APS IPMDH, beta-IPM dehydrogenase, beta-IPMDH, beta-isopropylmalate dehydrogenase, beta-isopropylmalic enzyme, Bs3-isopropylmalateDH, dehydrogenase, 3-isopropylmalate, IMDH, IPMDH, IPMDH1, IPMDH2, IPMDH3, isopropylmalate dehydrogenase, leuB, NAD-dependent isopropylmalate dehydrogenase, Saci_0600, SbIPMDH, SoIPMDH, threo-Ds-3-isopropylmalate dehydrogenase, Tt-beta-3-isopropylmalateDH, two-domain 3-isopropylmalate dehydrogenase, Ydr417cp

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.85 3-isopropylmalate dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.85 - 3-isopropylmalate dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2R,3S)-3-isopropylmalate + NAD+
(2S)-2-isopropyl-3-oxosuccinate + NADH + H+
show the reaction diagram
(2R,3S)-3-isopropylmalate + NAD+
2-isopropyl-3-oxosuccinate + NADH + H+
show the reaction diagram
(2R,3S)-3-isopropylmalate + NAD+
2-ketoisocaproate + NADH + H+ + CO2
show the reaction diagram
-
-
-
-
?
(2R,3S)-3-isopropylmalate + NAD+
2-oxoisocaproate + NADH + H+ + CO2
show the reaction diagram
(2R,3S)-3-isopropylmalate + NAD+
4-methyl-2-oxopentanoate + CO2 + NADH + H+
show the reaction diagram
(2R,3S)-3-isopropylmalate + NAD+
4-methyl-2-oxovalerate + CO2 + NADH + H+
show the reaction diagram
-
-
-
?
(2R,3S)-3-isopropylmalate + NAD+
?
show the reaction diagram
(2R,3S)-3-isopropylmalate + NAD+
D-3-isopropyl-2-oxosuccinate + NADH + H+
show the reaction diagram
(2R,3S)-3-isopropylmalate + thionicotinamide NAD+
2-oxoisohexanoate + thionicotinamideNADH + CO2
show the reaction diagram
(S)-malate + NAD+
pyruvate + NADH + CO2
show the reaction diagram
-
12% of the activity with 3-isopropylmalate
-
-
?
3-(2'-methylthio)ethylmalate + NAD+
? + NADH + H+
show the reaction diagram
-
-
-
?
3-ethylmalate + NAD+
3-ethylpyruvate + NADH + CO2
show the reaction diagram
3-isoamylmalate + NAD+
3-isoamylpyruvate + NADH + CO2
show the reaction diagram
-
-
-
-
?
3-isopropylmalate + NAD+
2-ketoisocaproate + CO2 + NADH + H+
show the reaction diagram
3-isopropylmalate + NAD+
2-ketoisocaproate + NADH + CO2
show the reaction diagram
3-isopropylmalate + NAD+
?
show the reaction diagram
-
-
-
-
?
3-methylmalate + NAD+
3-methylpyruvate + NADH + CO2
show the reaction diagram
-
-
-
-
?
3-tert-butylmalate + NAD+
3-tert-butylpyruvate + NADH + CO2
show the reaction diagram
-
-
-
-
?
beta-methylmalate + NAD+
2-oxobutyrate + NADH + CO2
show the reaction diagram
-
enzyme catalyzes the final step in the pyruvate pathway to 2-oxobutyrate
-
-
?
D-3-ethylmalate + NAD+
D-3-ethyl-2-oxosuccinate + NADH + H+
show the reaction diagram
D-3-isobutylmalate + NAD+
D-3-isobutyl-2-oxosuccinate + NADH + H+
show the reaction diagram
D-3-isopentylmalate + NAD+
D-3-isopentyl-2-oxosuccinate + NADH + H+
show the reaction diagram
D-3-methylmalate + NAD+
D-3-methyl-2-oxosuccinate + NADH + H+
show the reaction diagram
-
-
-
?
D-3-t-butylmalate + NAD+
D-3-t-butyl-2-oxosuccinate + NADH + H+
show the reaction diagram
-
-
-
?
D-malate + NAD+
pyruvate + NADH + CO2
show the reaction diagram
DL-3-isopropylmalate + NAD+
DL-isopropyl-3-oxosuccinate + NADH + H+
show the reaction diagram
-
-
-
-
?
erythro-Lg-beta-isopropylmalate + NAD+
?
show the reaction diagram
-
-
-
-
r
ethylmalate + NAD+
2-oxopentanoate + NADH + H+ + CO2
show the reaction diagram
-
-
-
-
?
homoisocitrate + NAD+
? + NADH + H+
show the reaction diagram
isopropylmalate + NAD+
?
show the reaction diagram
-
-
-
-
?
malate + NAD+
3-oxosuccinate + NADH + H+
show the reaction diagram
-
-
-
?
malate + NAD+
pyruvate + NADH + H+ + CO2
show the reaction diagram
malate + NADP+
pyruvate + NADPH + CO2
show the reaction diagram
-
-
-
-
?
propylmalate + NAD+
?
show the reaction diagram
-
-
-
-
r
tartrate + NAD+
?
show the reaction diagram
-
-
-
-
?
tartrate + NADP+
?
show the reaction diagram
-
-
-
-
?
tert-butylmalate + NAD+
2-hydroxy-4,4-dimethylpentanoate + NADH + H+ + CO2
show the reaction diagram
-
-
-
-
?
threo-D-3-isopropylmalate + NAD+
?
show the reaction diagram
threo-DL-isopropylmalate + NAD+
2-isopropyl-3-oxosuccinate + NADH
show the reaction diagram
additional information
?
-