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0.009 - 1700
(2R,3S)-3-isopropylmalate
0.038 - 18.77
3-(2'-methylthio)ethylmalate
1.36
D-malate
-
pH 7.5, 37°C
440
homoisocitrate
at pH 8.0 and 60°C
0.009
(2R,3S)-3-isopropylmalate
mutant enzyme R136K, at pH 7.5 and 25°C
0.109
(2R,3S)-3-isopropylmalate
mutant enzyme D292N, at pH 7.5 and 25°C
0.16
(2R,3S)-3-isopropylmalate
mutant R85V/Y86A, pH 8.0, 37°C
0.18
(2R,3S)-3-isopropylmalate
wild-type (2R,3S)-3-isopropylmalate dehydrogenase, pH 8.0, 37°C
0.192
(2R,3S)-3-isopropylmalate
mutant enzyme R146K, at pH 7.5 and 25°C
0.33
(2R,3S)-3-isopropylmalate
mutant E57V/S72I/R85M/Y86A/M208T/V238M/R310M, pH 8.0, 37°C
0.4
(2R,3S)-3-isopropylmalate
mutant E57V/S72I/R85M/Y86A/M208T/F217Y/V238M, pH 8.0, 37°C
0.429
(2R,3S)-3-isopropylmalate
mutant enzyme R146A, at pH 7.5 and 25°C
0.49
(2R,3S)-3-isopropylmalate
mutant H15Y/E57V/S72I/R85M/Y86A/M208T/F217Y/V238M/R310M, pH 8.0, 37°C
0.75
(2R,3S)-3-isopropylmalate
wild-type HICDH, pH 8.0, 37°C
0.94
(2R,3S)-3-isopropylmalate
mutant E57V/S72I/R85M/Y86A/M208T/F217Y/R310M, pH 8.0, 37°C
1.6
(2R,3S)-3-isopropylmalate
mutant S72I/R85M/Y86A/M208T/F217Y/V238M/R310M, pH 8.0, 37°C
1.92
(2R,3S)-3-isopropylmalate
mutant enzyme Y181A, at pH 7.5 and 25°C
2.14
(2R,3S)-3-isopropylmalate
mutant enzyme R174K, at pH 7.5 and 25°C
5.4
(2R,3S)-3-isopropylmalate
mutant E57V/S72I/R85M/Y86A/M208T/F217Y/V238M/R310M, pH 8.0, 37°C
19.29
(2R,3S)-3-isopropylmalate
mutant enzyme L132A, at pH 7.5 and 25°C
20.3
(2R,3S)-3-isopropylmalate
mutant L133F, pH not specified in the publication, temperature not specified in the publication
24.47
(2R,3S)-3-isopropylmalate
wild-type, pH not specified in the publication, temperature not specified in the publication
24.83
(2R,3S)-3-isopropylmalate
mutant enzyme L133A, at pH 7.5 and 25°C
25.7
(2R,3S)-3-isopropylmalate
mutant L134F, pH not specified in the publication, temperature not specified in the publication
32.32
(2R,3S)-3-isopropylmalate
mutant enzyme Y181F, at pH 7.5 and 25°C
34
(2R,3S)-3-isopropylmalate
-
pressure 250 MPa, 20°C, pH not specified in the publication
91.21
(2R,3S)-3-isopropylmalate
mutant enzyme Y181H, at pH 7.5 and 25°C
93
(2R,3S)-3-isopropylmalate
pressure 250 MPa, 20°C, pH not specified in the publication
110
(2R,3S)-3-isopropylmalate
-
pressure 200 MPa, 20°C, pH not specified in the publication
160
(2R,3S)-3-isopropylmalate
-
pressure 150 MPa, 20°C, pH not specified in the publication
180.3
(2R,3S)-3-isopropylmalate
mutant enzyme V235A, at pH 7.5 and 25°C
270
(2R,3S)-3-isopropylmalate
-
mutant enzyme I268A, at pH 7.6 and 25°C
336.3
(2R,3S)-3-isopropylmalate
mutant F137L, pH not specified in the publication, temperature not specified in the publication
340
(2R,3S)-3-isopropylmalate
pressure 200 MPa, 20°C, pH not specified in the publication
400
(2R,3S)-3-isopropylmalate
pressure 50 MPa, 20°C, pH not specified in the publication
440
(2R,3S)-3-isopropylmalate
pressure 150 MPa, 20°C, pH not specified in the publication
560
(2R,3S)-3-isopropylmalate
-
pressure 50 MPa, 20°C, pH not specified in the publication
570
(2R,3S)-3-isopropylmalate
wild-type, pH not specified in the publication, temperature not specified in the publication
590
(2R,3S)-3-isopropylmalate
-
mutant enzyme A266S, at pH 7.6 and 25°C
600
(2R,3S)-3-isopropylmalate
pressure 0.1 MPa, 20°C, pH not specified in the publication
620
(2R,3S)-3-isopropylmalate
-
mutant enzyme M106L, at pH 7.6 and 25°C
700
(2R,3S)-3-isopropylmalate
pressure 100 MPa, 20°C, pH not specified in the publication
870
(2R,3S)-3-isopropylmalate
-
pressure 100 MPa, 20°C, pH not specified in the publication
930
(2R,3S)-3-isopropylmalate
-
pressure 0.1 MPa, 20°C, pH not specified in the publication
983.7
(2R,3S)-3-isopropylmalate
wild-type, pH not specified in the publication, temperature not specified in the publication
1150
(2R,3S)-3-isopropylmalate
-
pH 7.5, 37°C
1303
(2R,3S)-3-isopropylmalate
wild type enzyme, at pH 7.5 and 25°C
1350
(2R,3S)-3-isopropylmalate
-
wild type enzyme, at pH 7.6 and 25°C
1700
(2R,3S)-3-isopropylmalate
at pH 8.0 and 60°C
0.038
3-(2'-methylthio)ethylmalate
wild-type, pH not specified in the publication, temperature not specified in the publication
0.1
3-(2'-methylthio)ethylmalate
mutant F137L, pH not specified in the publication, temperature not specified in the publication
0.33
3-(2'-methylthio)ethylmalate
wild-type, pH not specified in the publication, temperature not specified in the publication
2.59
3-(2'-methylthio)ethylmalate
mutant L134F, pH not specified in the publication, temperature not specified in the publication
4.76
3-(2'-methylthio)ethylmalate
mutant L133F, pH not specified in the publication, temperature not specified in the publication
18.77
3-(2'-methylthio)ethylmalate
wild-type, pH not specified in the publication, temperature not specified in the publication
0.12
NAD+
wild-type (2R,3S)-3-isopropylmalate dehydrogenase, pH 8.0, 37°C
0.23
NAD+
mutant R85V/Y86A, pH 8.0, 37°C
0.25
NAD+
mutant H15Y/E57V/S72I/R85M/Y86A/M208T/F217Y/V238M/R310M, pH 8.0, 37°C
0.33
NAD+
mutant E57V/S72I/R85M/Y86A/M208T/V238M/R310M, pH 8.0, 37°C
0.38
NAD+
mutant E57V/S72I/R85M/Y86A/M208T/F217Y/V238M, pH 8.0, 37°C
0.41
NAD+
wild-type HICDH, pH 8.0, 37°C
1.1
NAD+
mutant E57V/S72I/R85M/Y86A/M208T/F217Y/R310M , pH 8.0, 37°C
1.4
NAD+
mutant S72I/R85M/Y86A/M208T/F217Y/V238M/R310M, pH 8.0, 37°C
4.2
NAD+
mutant E57V/S72I/R85M/Y86A/M208T/F217Y/V238M/R310M, pH 8.0, 37°C
60
NAD+
-
mutant enzyme I268A, at pH 7.6 and 25°C
100
NAD+
-
mutant enzyme A266S, at pH 7.6 and 25°C
180
NAD+
-
wild type enzyme, at pH 7.6 and 25°C
190
NAD+
-
mutant enzyme M106L, at pH 7.6 and 25°C