1.1.1.80: isopropanol dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about isopropanol dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.1.1.80
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1.1.1.80
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acetone
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biocatalyst
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diode
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biofuels
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autoethanogenum
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2-propanol
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2,3-butanediol
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acetogenic
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biocatalytic
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emitted
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nadh-dependent
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n-butanol
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diagnostics
- 1.1.1.80
- acetone
-
biocatalyst
-
diode
-
biofuels
- autoethanogenum
- 2-propanol
- 2,3-butanediol
-
acetogenic
-
biocatalytic
-
emitted
-
nadh-dependent
- n-butanol
- diagnostics
Reaction
Synonyms
ADH, IDH, isopropanol dehydrogenase, NADP-dependent isopropanol dehydrogenase, NADPH-dependent primary-secondary alcohol dehydrogenase, S-ADH, TBADH, TVAG_228780
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Substrates Products
Substrates Products on EC 1.1.1.80 - isopropanol dehydrogenase (NADP+)
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REACTION DIAGRAM
4-phenyl-2-butanone + NADPH + H+
4-phenyl-2-butanol + NADP+
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r
butan-2-ol + NADP+
butanone + NADPH + H+
preferred direction of the reaction is reduction rather than oxidation
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r
propan-2-ol + NAD+
acetone + NADH
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NAD+ effectively substitutes for NADP+
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propan-2-ol + NADP+
acetone + NADPH + H+
preferred direction of the reaction is reduction rather than oxidation
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r
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also acts on short-chain secondary alcohols and, slowly, on primary alcohols
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additional information
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possibly takes part in the further metabolic reactions of the fragments formed from the side-chain of the steroid hormone precursor in the adrenals or gonads
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additional information
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enzyme transfers the pro-R hydrogen from the pyridine 4 position of the reduced coenzyme. This stereospecificity is stable over a broad range of temperatures up to 70°C and different concentrations of the coenzyme (catalytic or stoichiometric). NADP+ and its synthetic analogs, 3-acetylpyridine-ADP+ and thio-NADP+, can be used successfully
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